• 李贞龙

    博士,助理教授,博士生导师
    地址:东安路131号,上海 200032
    邮箱:lzlecnu@163.com

工作经历
助理教授,复旦大学,生物医学研究院(2026.04-至今)
专职科研人员,美国国家医疗中心希望之城(City of Hope)(2023.10-2026.03)
博士后,美国国家医疗中心希望之城(City of Hope)(2018.09-2023.10)
教育经历
博士,华东师范大学 (2013.09-2018.06)
学士,菏泽学院 (2008.09-2013.06)
所获人才项目
国家高层次青年人才(海外),2024
研究方向
以固有免疫为核心的新型免疫调控与细胞治疗体系的构建,系统探索其在肿瘤免疫与炎症疾病中的转化应用。研究重点涵盖固有淋巴细胞(ILCs)、自然杀伤(NK)细胞与T细胞的免疫调控机制、树突状细胞功能、嵌合抗原受体(CAR)NK与CAR-T细胞疗法、肿瘤微环境与免疫逃逸、血液及骨髓干细胞移植,以及神经免疫与皮肤免疫等交叉领域。实验室系统整合单细胞多组学、空间转录组学与功能免疫学等前沿技术,围绕固有免疫细胞在肿瘤发生、发展与炎症调控中的关键作用开展基础机制与转化医学研究。
招生专业
生物化学与分子生物学
代表论文

1.     Zhenlong Li#, Rui Ma#, Hejun Tang#, Jiamin Guo, Zahir Shah, Jianying Zhang, Ningyuan Liu, Shuai Cao, Guido Marcucci, David Artis, Michael A. Caligiuri*, Jianhua Yu*. Cell. 2024. Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death. (Reported by many news and journals including Nature Reviews Immunology, Cancer Discovery, Cell Research, etc.)

2.     Zhenlong Li#, Rui Ma, Hejun Tang, Michael A. Caligiuri*, Jianhua Yu*. STAR Protocols. 2024.Isolation, expansion, and adoptive transfer of human ILC2s for the treatment of mice bearing liquid and solid tumors.

3.     Zhenlong Li#, Rui Ma#, Shoubao Ma#, Lei Tian, Ting Lu, Jianying Zhang, Bethany L Mundy-Bosse, Bin Zhang, Guido Marcucci, Michael A Caligiuri*, Jianhua Yu*. Nature Immunology. 2022. ILC1s control leukemia stem cell fate and limit development of AML. (Journal cover story, Highlighted by Cancer Research, Faculty Opinions recommended).

4.     Zhenlong Li#, Rui Ma#, Ningyuan Liu#, Hejun Tang, Jianying Zhang, Guido Marcucci, Michael A. Caligiuri*, Jianhua Yu*. Nature Communications. 2026. Human ILC1s target leukemia stem cell differentiation and control development of AML.

5.     Zhenlong Li#, Yaoxin Gao#, Cong He#, Huan Wei, Jiang Zhang, Hongmei Zhang, Lulu Hu, Wenzheng Jiang*. The Journal of Immunology. 2021.Purinergic Receptor P2Y6 Is a Negative Regulator of NK Cell Maturation and Function.

6.     Zhenlong Li#, Cong He#, Jiang Zhang, Hongmei Zhang, Huan Wei, Shijia Wu, and Wenzheng Jiang*. The Journal of Immunology. 2020. P2Y6 Deficiency Enhances DC-mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis.

7.     Rui Ma#, Zhenlong Li#, Hejun Tang#, Xiaojing Wu#, Lei Tian, Zahir Shah, Tasha Barr, Jianying Zhang, Srividya Swaminathan, Michael A. Caligiuri*, Jianhua Yu*. Nature Communications. 2025. NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity.

8.     Tianchen Xiong#, Ge Wang#, Peng Yu#, Zhenlong Li#, Debao Li, Jianying Zhang, Song Lu, Ruiqi Yang, Xiaolong Lian, Jianhong Mi, Rui Ma, Zhiyao Li, Guido Marcucci, Tingting Zhao*, Michael A. Caligiuri*, Jianhua Yu*. The Journal of Clinical Investigation. 2025. Targeting CD155 with CAR-T cells to treat both leukemia and solid tumors.

9.     Shoubao Ma#, Jingjing Han#, Zhenlong Li#, Sai Xiao, Jianying Zhang, Jiazhuo Yan, Tingting Tang, Tasha Barr, Andrew S. Kraft, Michael A. Caligiuri*, Jianhua Yu*. Science Immunology.2023.An XBP1s–PIM2 positive feedback loop controls IL-15–mediated survival of natural killer cells.

10.  Rui Ma#, Zhenlong Li#, E Antonio Chiocca, Michael A. Caligiuri*, Jianhua Yu*.Trends in cancer. 2022. The emerging field of oncolytic virus-based cancer immunotherapy.

11.  Rui Ma#, Ting Lu#, Zhenlong Li#, Kun-Yu Teng, Anthony G Mansour, Melissa Yu, Lei Tian, Bo Xu, Shoubao Ma, Jianying Zhang, Tasha Barr, Yong Peng, Michael A Caligiuri*, Jianhua Yu*. Cancer Research. 2021. An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma.

12.  Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li*, Lidan Cui*, Xiangzhan Zhu*.Advanced science. 2026. Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy–Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis.

13.  Jiang Zhang#, Zhenlong Li#, Xuefei Hu, Qiong Su, Cong He, Jing Liu, Hua Ren, Min Qian, Junling Liu, Shufang Cui, Wenzheng Jiang*. Brain, Behavior and Immunity. 2016. Knock of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and cell differentiation by dendritic cells.

14.  Zahir Shah#, Lei Tian#, Zhixin Li#, Lewei Jin, Jianying Zhang, Zhenlong Li, Tasha Barr, Hejun Tang, Mingye Feng, Michael A Caligiuri, Jianhua Yu. Cell stem cell. 2024.Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer. (Featured in Preview by Cell Stem Cell)

15.  Lei Tian#, Bo Xu#, Yuqing Chen, Zhenlong Li, Jing Wang, Jianying Zhang, Rui Ma, Shuai Cao, Weidong Hu, E. Antonio Chiocca, Balveen Kaur, Michael A Caligiuri*, Jianhua Yu*. Nature Cancer, 2023. Specific Targeting of Glioblastoma with an Oncolytic Virus Expressing a Cetuximab-CCL5 Fusion Protein via Innate and Adaptive Immunity.


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