医学博士,教授,博士生导师
复旦大学基础医学院教授,复旦大学儿科医院兼职教授
地址:上海市东安路130号13号楼519
电话:021-54237441(办公室),021-54237414(实验室)
邮箱:duanma@fudan.edu.cn
实验室主页:http://mdlab.fudna.edu.cn
Yang F, Chen C, Zhou Q, Gong Y, Li R, Li C, Klämpfl F, Freund S, Wu X, Sun Y, Li X, Schmidt M, Ma D*, Yu Y*. (2017) Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study. Sci Rep 7:45360
Ma J, Yang J, Jian W, Wang X, Xiao D, Xia W, Xiong L, Ma D*. (2017) A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer. J Cancer Res Clin Oncol 143(4):631-637
Xiao JJ, Jin KY, Wang JP, Ma J, Zhang J, Jiang N, Wang HJ, Luo XP, Fei J, Wang ZG, Yang X, Ma D*. (2017) Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway. Int J Cardio 228:605-614
Ma Z, Xia W, Liu F, Ma J, Sun S, Zhang J, Jiang N, Wang X, Hu J, Ma D*. (2016) SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss. Hum Mol Genet Dec 2
Wang J, Xiao J, Wen D, Wu X, Mao Z, Zhang J, Ma D*. (2016) Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice. Mol Carcinog 55(5):882-896
Liang F, Diao L, Jiang N, Zhang J, Wang HJ, Zhou WH, Huang GY, Ma D*. (2015) Chronic exposure to ethanol in male mice may be associated with hearing loss in offspring. Asian J Androl 17(6):985-990
Liu F, Yang F, Wen D, Xia W, Hao L, Hu J, Zong J, Shen X, Ma J, Jiang N, Sun S, Zhang J, Wang H, Wang X, Ma Z, Ma D*. (2015) Grhl1 deficiency affects inner ear development in zebrafish. Int J Dev Biol 59(10-12):417-423
Wang Y, Wen Z, Shen J, Cheng W, Li J, Qin X, Ma D*, Shi Y*. (2014) Comparison of the performance of Ion Torrent chips in noninvasive prenatal trisomy detection. J Hum Genet 59(7):393-396
Liang F, Diao L, Liu J, Jiang N, Zhang J, Wang H, Zhou W, Huang G, Ma D*. (2014) Paternal ethanol exposure and behavioral abnormities in offspring: Associated alterations in imprinted gene methylation. Neuropharmacology 81:126-133
Xu F, Wang YL, Chang JJ, Du SC, Diao L, Jiang N, Wang H, Ma D*, Zhang J*. (2014) Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/β-catenin signalling pathway by directly binding casein kinase 1ε. Biochem J 458(1):159-169
Zhang J, Luo X, Ma XJ, Wu Y, Li WC, Wang HJ, Huang GY*, Ma D*. (2013) MicroRNA deregulation in right ventricular outflow tract myocardium in nonsyndromic tetralogy of fallot. Canadian Journal of Cardiology 29(12):1695-1703
Zhang YL, Wang LN, Zhou WH, Zhang J, Wang HJ, Jiang Q, Deng SS, Li WH, Wang L, Li HW, Mao ZH, Ma D*. (2013) Tissue factor pathway inhibitor-2: A novel gene involved in zebrafish central nervous system development. Developemntal Biology 381(1):38-49
Li J, Cao Y, Ma XJ, Wang HJ, Zhang J, Luo X, Chen W, Wu Y, Meng Y, Zhang J, Yuan Y, Ma D*, Huang GY*. (2013) Roles of miR-1-1 and miR-181c in ventricular septal defects. Int J Cardiol 168(2):1441-1446
Sheng W, Wang HJ, Zhang P, Qian YY, Wu Y, Ma XJ, Zheng FY, Chen L, Huang GY*, Ma D*. (2012) LINE-1Methylation Status and Its Association with Tetralogy of Fallot in Chinese Infants. BMC Medical Genomic 5:20
Chen YT, Zhang J, Wang HJ, Xu C, Du YY, Luo X, Zheng FY, Zhao JY, Zhang HW, Ma D*. (2012) miRNA-135a promotes migration and invasion of breast cancer by targeting HOXA10. BMC Cancer 12(1):111
Xu C, Deng F, Mao Z^, Zhang J, Wang H, Wang J, Mu J, Deng S, Ma D*. (2012) The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells. Biochemical Journal 441(2):665-674
Zhang J, Du YY, Lin YF, Chen YT, Yang L, Wang HJ, Ma D*. (2008) The cell growth suppressor, mir-126, targets IRS-1. Biochem Biophys Res Commun 377(1):136-140
Guo HS, Kong DS, Lin YF, Zhang HW, Liu J, Zhang N, Song HY, Tang QQ, Ma D*. (2007) Tissue factor pathway inhibitor-2 could be repressed by CpG hypermethylation through inhibition of KLF6 binding in high metastatic breast cancer cell MDA-MB-435. BMC Molecular Biology 8:110
Lin YF, Zhang N*, Guo HS, Kong DS, Jiang T, Liang W, Zhao ZH, Liu J, Tang QQ, Ma D*. (2007) Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway. Apoptosis 12(12):2163-2173
Bai H, Ma D*, Zhang YG, Zhang N, Kong DS, Guo HS, Mo W, Tang QQ, Song HY. (2005) Molecular Design and Characterization of Recombinant Long Half-life Human Tissue Factor Pathway Inhibitor Mutants. Thrombosis and Haemostasis 93:1055-1060
Xia W, Hu J, Liu F, Ma J, Sun S, Zhang J, Jin K, Huang J, Jiang N, Wang X, Li W, Ma Z, Ma D*. New role of LRP5, associated with non-syndromic autosomal recessive hereditary hearing loss. Hum Mutat. 2017 Jul 4. doi: 10.1002/humu.23285. [Epub ahead of print]
Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D*, Wang H. Hypomethylation and decreased expression of BRG1 in the myocardium of patients with congenital heart disease. Birth Defects Res. Birth Defects Res. 2017 Jun 24.
Shi Q, Xiong B, Zhong J, Wang H, Ma D*, Miao C. MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239. Mol Immunol. 2017;88:79-88
Yang J, Jin K, Xiao J, Ma J, Ma D. Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis. Front Med. 2017 May 27. doi: 10.1007/s11684-017-0522-y.
Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, Weng M, Shi Q, Ma D, Miao C. Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways. Cell Death Dis. 2017;8(5):e2763.
Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H. Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation. J Transl Med. 2017;15(1):69.
Yang F#, Chen C#, Zhou Q, Gong Y, Li R, Li C, Klämpfl F, Freund S, Wu X, Sun Y, Li X, Schmidt M, Ma D, Yu Y. Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study. Sci Rep. 2017;7:45360.
Ma J, Yang J, Jian W, Wang X, Xiao D, Xia W, Xiong L, Ma D. A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer. J Cancer Res Clin Oncol. 2017;143(4):631-637.
Ma Z, Xia W, Liu F, Ma J, Sun S, Zhang J, Jiang N, Wang X, Hu J, Ma D. SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss. Hum Mol Genet. 2017;26(2):383-394.
Xiao JJ, Jin KY, Wang JP, Ma J, Zhang J, Jiang N, Wang HJ, Luo XP, Fei J, Wang ZG, Yang X, Ma D*. Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway. Int J Cardio. 2017;228:605-614
授权发明专利
Duan Ma, Jingui Mu, Jiping Wang, Huijun Wang, Wang Liang. Genetically Modified TFPI And Method Of Treating Coagulation using the same. USA Patent No. 8912143
Duan Ma, Jingui Mu, Jiping Wang, Huijun Wang, Wang Liang. Genetically Modified TFPI And Method Of Making The Same. USA Patent No. US 20120065135
马端,张进,王慧君,杨璐。一种检测DNA主动去甲基化的方法。专利号:ZX201110077002.7
马端,木金贵,王际平,王慧君,梁旺。一种酵母高效表达长效重组人组织因子途径抑制物的方法。专利号:ZL200910046024x
马端,程训佳,刘静,木金贵,梁旺,王际平。一种人源抗组织因子Fab及其制备方法。专利号:ZL200810034154.7
马端,宋后燕。重组人组织因子途径抑制物活性肽及其制备。专利号:ZL011 26949.9
马端,宋后燕,白浩,张农。长效重组组织因子途径抑制物及其制备方法。专利号:ZL03151203.8
著作
遗传病相关个体化医学检测技术指南(试行)。共同起草人。国家卫计委个体化医学检测技术专家委员会。2014
常见出生缺陷产前诊断的行业规范与指南,副主编。人民卫生出版社。2013
临床遗传学,共同主编。上海科技出版社。2013
免疫生物学/Immunobiology,共同主译。人民卫生出版社。2008
生物学前沿技术在医学研究中的应用,主编。复旦大学出版社。2007
分子医学导论,副主编。复旦大学出版社,2006