博士,研究员,博士生导师
地址:东安路 270 号 2 号楼,上海 200032
邮箱:weiguohu@fudan.edu.cn
1.Li L, Ding P, Lv X, Xie S, Li L, Chen J, Zhou D, Wang X, Wang Q, Zhang W, Xu Y, Lu R, Hu W*. CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity. Cancer Immunol Res. 2022 Dec 2;10(12):1475-1489.
2.Ding P, Xu Y, Li L, Lv X, Li L, Chen J, Zhou D, Wang X, Wang Q, Zhang W, Liao T, Ji QH, Lei QY, Hu W*. Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis. Cell Rep. 2022 May 31;39(9):110851.
3.Song J, Zhao R, Yan C, Luo S, Xi J, Ding P, Li L, Hu W*, Zhao C*. A Targeted Complement Inhibitor CRIg/FH Protects Against Experimental Autoimmune Myasthenia Gravis in Rats via Immune Modulation. Front Immunol.2022 Jan 26;13:746068.
4.Zhang W, Zhang X, Huang S, Chen J, Ding P, Wang Q, Li L, Lv X, Li L, Zhang P, Zhou D, Wen W, Wang Y, Lei QY, Wu J, Hu W*. FOXM1D Potentiates PKM2-mediated tumor glycolysis and angiogenesis. Mol Oncol. 2021 May;15(5):1466-1485.
5.Ding P, Li L, Li L, Lv X, Zhou D, Wang Q, Chen J, Yang C, Xu E, Dai W, Zhang X, Wang N, Wang Q, Zhang W, Zhang L, Zhou Y, Gu H, Lei Q, Zhou X, Hu W*. C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation. Theranostics. 2020 Jul 9;10(19):8619-8632.
6.Wang Q#, Zhang P#, Zhang W, Zhang X, Chen J, Ding P, Li L, Lv X, Li L, Hu W*. PI3K Activation Is Enhanced by FOXM1D Binding to p110 and p85 Subunits. Signal Transduct Target Ther. 2020 Jun 30;5(1):105. doi: 10.1038/s41392-020-00218-3.
7.Chen J, Ge X, Zhang W, Ding P, Du Y, Wang Q, Li L, Fang L, Sun Y, Zhang P, Zhou Y, Zhang L, Lv X, Li L, Zhang X, Zhang Q, Xue K, Gu H, Lei Q, Wong J, Hu W*. PI3K/AKT Inhibition Reverses R-CHOP Resistance by Destabilizing SOX2 in Diffuse Large B Cell Lymphoma. Theranostics. 2020 Feb 10;10(7):3151-3163.
8.Ge X, Chen J, Li L, Ding P, Wang Q, Zhang W, Li L, Lv X, Zhou D, Jiang Z, Zeng H, Xu Y, Hou Y*,Hu W*. Midostaurin potentiates rituximab antitumor activity in Burkitt's lymphoma by inducing apoptosis. Cell Death Dis. 2018; 10(1):8.
9.Hu C, Li L, Ding P, Li L, Ge X, Zheng L, Wang X, Wang J, Zhang W, Wang N, Gu H, Zhong F, Xu M, Rong R, Zhu T*,Hu W*.Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling. J Immunol.2018; 201(12):3717-3730.
10.Zhou Y, Chu L, Wang Q, Dai W, Zhang X, Chen J, Li L, Ding P, Zhang L, Gu H, Li L, Lv X, Zhang W, Zhou D, Zhang P, Cai G, Zhao K*,Hu W*. CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair. Cell Death Dis. 2018; 9(9):887.
11.Zhang X, Zhang L, Du Y, Zheng H, Zhang P, Sun Y, Wang Y, Chen J, Ding P, Wang N, Yang C, Huang T, Yao X, Qiao Q, Gu H, Cai G, Cai S, Zhou X, Hu W*. A novel FOXM1 isoform, FOXM1D, promotes epithelial-mesenchymal transition and metastasis through ROCKs activation in colorectal cancer. Oncogene. 2017; 36(6):807-819.
12.Chen J, Ding P, Li L, Gu H, Zhang X, Zhang L, Wang N, Gan L, Wang Q, Zhang W, Hu W*. CD59 Regulation by SOX2 Is Required for Epithelial Cancer Stem Cells to Evade Complement Surveillance. Stem Cell Reports. 2017 January 10; 8(1): 140–151. Stem Cell Reports_ Best of 2016-2017
13.Yang C, Ding P, Wang Q, Zhang L, Zhang X, Zhao J, Xu E, Wang N, Chen J, Yang G,Hu W*, Zhou X*. Inhibition of Complement Retards Ankylosing Spondylitis Progression. Scientific Reports.2016 Oct 4;6:34643.
14.Qiao Q,Teng X,Wang N,Lu R,Guo L,Zhang X,Du Y,Wang W,Chen S,Wu Q,He G,Wang Y, Hu W*.A novel CRIg-targeted complement inhibitor protects cells from complement damage. FASEB J.2014, 28(11):4986-99.
15.Du Y,Teng X,Wang N,Zhang X,Chen J,Ding P,Qiao Q,Wang Q,Zhang L,Yang C,Yang Z,Chu Y,Du X,Zhou X*,Hu W*. NF-κB and enhancer-binding CREB protein scaffolded by CREB-binding protein (CBP)/p300 proteins regulate CD59 protein expression to protect cells from complement attack. J Biol Chem. 2014; 289(5):2711-24.
16.Hu W*,Ge X, You T, Xu T, Zhang J, Wu G, Peng Z, Chorev M, Aktas BH, Halperin JA, Brown JR, and Qin X*. Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis. Cancer Research. 2011, 71(6):2298-307.
17.Hu W#, Jin R#, Zhang J, You T, Bronson RT, Peng Z,Ge X, Loscalzo J, and Qin X*. The Mechanisms of Fatal Pulmonary Arterial Hypertension in a Unique Rapid Hemolysis Model. Blood.2010, 116(9):1613-22.
18.Hu W#, Yu Q #, Hu N, Byrd D, Shikuma C, Shiramizu B, Halperin JA, Qin X*. A high affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: Implications for treatment of HIV-1/AIDS. Journal of Immunology. 2010,184(1):359-368.
19.Qin X #,Hu W#, Song W, Grubissich L, Song Y, Wu G, Hu X, Ferris S, Dobarro M, Bauer S, Feelisch M, Leopold JA, Loscalzo J, Halperin JA*. Balancing role of nitric oxide in complement-mediated platelet activation of mCd59a and mCd59b double knockout mice. American Journal of Hematology.2009, 84(4):221-7.
20.Hu W, Ferris S, Tweten RK, Wu G, Gao B, Bronson RT, Halperin JA and Qin X*. Conditional, rapid and targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nature Medicine. 2008; 14 (1): 98-103.
21.Zhou X #,Hu W#, Qin X*. The Role of Complement in the Mechanism of Action of Rituximab for B-Cell Lymphoma: Implications for Therapy. The Oncologist.2008; 13: 954-966.