杰出青年
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  • 蓝斐

    博士,研究员,博士生导师
    地址:东安路 131号,明道楼 504 室,上海 200032
    电话:021-54237874(办公室),021-54237821(实验室)
    邮箱:fei_lan@fudan.edu.cn

    多能干细胞Naïve与Premed状态的表观遗传调控机制研究获批“干细胞及转化研究试点”专项(青年科学家项目)首席,获批经费:589万

工作经历
研究员,复旦大学,生物医学研究院/附属中山医院(2012.12-今)
研究员,美国Constellation Pharmaceuticals(2008.2-2012.12)
教育经历
博士,哈佛大学,医学院细胞与发育生物学系(2002-2008)
硕士,复旦大学,上海医学院原肿瘤研究所(1999-2002)
学士,复旦大学,生命科学学院生物化学系(1995-1999)
所获人才项目
国家杰出青年科学基金,基金委,2019
上海市优秀学术带头人,上海市科委,2016
上海高校特聘教授,上海市教育委员会,2012
所获奖项

中源协和生命医学创新突破奖,中源协和基金会、中国科学院大学,2017
中国十大医学进展(基础类),中国科学报社、人民网,2017
谈家桢生命科学奖(创新奖),上海市生物医药行业协会,2016
上海市“优秀学术带头人”,上海市科委,2016

学术任职

上海市医学表观遗传重点实验室,副主任(2020年1月—)
复旦大学生物医学研究院,科研副院长(2019年8月—)
科技部医学表观遗传与分子代谢示范性国际科技合作基地,副主任(2016年12月—)
中国细胞生物学会染色质生物学专业委员会,秘书长(2016年1月—)
中国生物化学与分子生物学会基因专业委员会,副主任(2015年1月—)
上海市教委表观遗传重点实验室,主任(2014年1月)

研究方向

受精卵中的一个基因组怎样分化成不同类别细胞的基因组?时光在我们的基因组上又会留下怎样的印记?这些都是表观遗传研究的范畴。
本课题组致力于研究表观遗传学领域中组蛋白甲基化的调控和识别机理,揭示表观遗传异常在疾病发生过程中的作用。主要成果体现在两类表观修饰识别子的机制和肿瘤相关性的研究中:发现增强子“过度活化态”组蛋白甲基化特征及其识别子RACK7的调控机制,并阐明该机制的缺失可导致肿瘤转移;发现人组蛋白变体H3.3甲基化的特异性识别子BS69及其在mRNA剪切过程中的关键作用,并揭示了BS69缺失导致肿瘤发生发展的机制;在多种哺乳类细胞中鉴定到罕见组蛋白甲基化修饰H3K14me3。博士期间参与了多类去甲基化酶家族的发现和研究工作。博士期间参与了多类去甲基化酶家族的发现和研究工作。
课题组长蓝斐主持和参与多项国家和省部级项目,包括国家重点研发计划(青年项目首席)、国家自然科学基金面上项目和重大集成、上海市教委项目等。迄今为止,已在国内外学术刊物上发表论文40篇,其中以第一作者或通讯作者在包括Cell、Nature、Molecular Cell、Cell Research、Protein & Cell、PNAS、Cell Reports、Oncogene、JBC等国际主流杂志上发表论文20多篇。
代表论文
  1. 1.Yao Chen, Ruitu Lv, Bowen Rong, Yuxuan Zheng, Zhen Lin, Ruofei Dai, Xi Zhang, Nannan Xie, Siqing Wang, Fuchou Tang*, Fei Lan* and Ming-Han Tong* (2020) Refined Spatial-temporal Epigenomic Profiling Reveals Intrinsic Connection between PRDM9-mediated H3K4me3 and the Fate of Double-stranded Breaks. Cell Research,2020(* Correspondence)

    2.Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen*, Feizhen Wu*, Fei Lan* (2019) DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation. Protein & Cell, 2019, Nov 22 Early online, PMID 31758527(* Correspondence)

    3.Jianqing Wang*, Chenxi He, Peng Gao, Siqing Wang, Ruitu Lv, Huihui Zhou, Qidong Zhou, Ke Zhang, Jian Sun, Caibin Fan, Guanxiong Ding* and Fei Lan* (2019) HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer. Oncogene, 2019, Oct 21 Early Online, PMID 31636385(* Correspondence)

    4.Zhennan Shi, Siyuan Xu, Shenghui Xing, Ke Yao, Lei Zhang, Luxi Xue, Bisi Miao, Peng Zhou, Ming Wang, Guoquan Yan, Pengyuan Yang, Jing Liu, Zeping Hu*, Fei Lan*2019Mettl17, a Regulator of Mitochondrial Ribosomal RNA Modifications, Is Required for the Translation of Mitochondrial Coding Genes. FASEB J., 2019, Nov., 33(11), 13040-13050(* Correspondence)

    5.Bisi Miao, Chuanyuan Wei, Zijun Qiao, Weiyu Han, Xiaoqiang Chai, Jiacheng Lu, Chao Gao, Ruizhao Dong, Dongmei Gao, Cheng Huang, Aiwu Ke, Jian Zhou, Jia Fan, Guoming Shi*, Fei Lan*, Jiabin Cai*2019eIF3a Mediates HIF1α-dependent Glycolytic Metabolism in Hepatocellular Carcinoma Cells Through Translational Regulation Am. J. Cancer Research, 2019, 9 (5) 1079-1090(* Correspondence)

    6.Zhao B, Xu W, Rong B, Chen G, Ye X, Dai R, Li W, Chen J, Cai J, Song L, Luo ZQ, Zeng R, Shi Y, Han JJ, Lan F*. H3K14me3 Genomic Distributions and its regulation by KDM4 family demethylases. Cell Research. 2018 Nov;28(11):1118-1120. Epub 2018 Oct 18. (* Correspondence)

    7.Zuo X, Rong B, Li L, Lv R, Lan F*, Tong MH*. The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. J. Boil. Chem. 2018 Jun 15;293(24):9188-9197. Epub 2018 May 1.(* Correspondence)

    8.Shen H, Xu W, Lan F*. Histone lysine demethylases in mammalian embryonic development. (Review) Exp Mol Med. 2017 Apr 28;49(4):e325. (* Correspondence)

    9.Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F*, Shi Y*. Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency. Cell Rep. 2016 Oct 18;17(4):997-1007. (* Correspondence)

    10.Shen H, Xu W, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Shao Z-M, Yang PY, Wu FZ, Shi YG, Shi Y*, Lan F*. Suppression of Enhancer Over-activation by a RACK7-Histone Demethylase Complex. Cell. 2016 Apr 7;165(2):331-42. (* Correspondence)

    11.Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F*, He QY*, Zhang G*, Wang T*. Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria. J Proteome Res. 2015 Sep 4;14(9):3645-57. (* Correspondence)

    12.Zhu L, Lv R, Kong L, Cheng H*, Lan F*, Li X*. Genome-Wide Mapping of 5mC and 5hmC Identified Differentially Modified Genomic Regions in Late-Onset Severe Preeclampsia: A Pilot Study. PLoS One. 2015 Jul 27;10(7) (* Correspondence)

    13.Lan F*, Shi Y*. Histone H3.3 and Cancer: a potential reader connection. (Review) Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6814-9. (* Correspondence)

    14.Guo R, Zheng LJ, Park JW, Xu WQ, Chen H, Qiu JS, Lv RT, Wang ZT, Yang PY, Wu FZ, Shi XB, Fu XD, Shi X, Shi YG, Xing Y*, Lan F*, Shi Y*. BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing. Mol Cell. 2014 Oct 23;56(2):298-310. (* Correspondence)

    15.Lan F*, Nottke AC*, Shi Y. Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol. 2008 Jun;20(3):316-25. Epub 2008 Apr 25. (* Co-first)

    16.Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.A histone H3 lysine 27 demethylase regulates animal posterior development. Nature Article. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12.

    17.Lan F*, Collins RE*, De Cegli R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Shi Y. Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature. 2007 Aug 9;448(7154):718-22. (* Co-first)

    18.Lan F, Zaratiegui M, Villén J, Vaughn MW, Verdel A, Huarte M, Shi Y, Gygi SP, Moazed D, Martienssen RA, Shi Y. S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol Cell. 2007 Apr 13;26(1):89-101.

    19.Iwase S*, Lan F*, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23;128(6):1077-88. Epub 2007 Feb 22. (* Co-first)

    20.Shi YJ, Matson C*, Lan F*, Iwase S, Baba T, Shi Y. Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 2005 Sep 16;19(6):857-64. (* Co-second)

    21.Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004 Dec 29;119(7):941-53.


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