1.       Zhang Y#, Shen X#, Shen Y#, Wang C#, Yu C, Han J, Cao S, Qian L, Ma M, Huang S, Wen W, Yin M, Lei QY*. Cytosolic acetyl-coenzyme A is a signaling metabolite to control mitophagy. Nature. 2026;649(8098):1022-1031.

2.       Ma QX#, Zhao R#, Han JX, Zhu WY, Xu MD, Zhang XY, Yan GQ, Wen, WY, Han GC, Luo M, Yin M*, Li JT*, Lei QY*. Tumor-derived BCKAs activate Notch signalling in tumor-associated macrophages to limit immunity. Nat Immunol. 2026;27(6):1169-1183. (highlighted by Nature Immunology)

3.       Lei MZ#, Zhu WY#, Wang C, Zhang F, Li ML, Zhang Y, Qu J, Luo ZG, Li JT, Li ZX, Yin M*, Lei QY*. Targeting methionine-induced pyroptosis enhances anti-tumor immunity. Sci China Life Sci. 2026;69(5):1604-1619.

4.       Chen MY#, Sun CY#, Zhao R, Guan XL, Li ML, Zhang F, Wan ZH, Feng JX, Yin M*, Lei QY*, Ma QX*. BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival. Mol Cell. 2025;85(13):2581-2596. (highlighted by Molecular Cell)

5.       Ming H#, Tan J#, Cao SY, Yu CP, Qi YT, Wang C, Zhang L, Liu Y, Yuan J, Yin M*, Lei QY*. NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis. Nat Metab. 2025;7(1):120-136.

6.       Shen Y#, Zheng LL#, Fang CY, Xu YY, Wang C, Li JT, Lei MZ, Yin M, Lu HJ*, Lei QY*, Qu J*.ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation. Cell Rep. 2024;43(2):113720.

7.       Qian L#, Li N#, Lu XC#, Xu MD#, Liu Y, Li KY, Zhang Y, Hu KW, Qi YT, Yao J, Wu YL, Wen WY, Huang SL, Chen ZJ, Yin M, Lei QY*. Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression. Nat Metab. 2023;5(7):1159-1173.

8.       Li ML#, Cao SY, Qu J, Zhang L, Gao Q, Wang X, Yin M, Liu Y, Lei MZ*, Lei QY*.S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiency. Development. 2023; 150(20):dev201135. doi: 10.1242/dev.201135.

9.       Ma QX#, Zhu WY, Lu XC, Jiang D, Xu F, Li JT, Zhang L, Wu YL, Chen ZJ, Yin M*, Huang HY*, Lei QY*. BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16. Nat Metab. 2022;4(1):106-122. Highlight in Nature Reviews Endocrinology

10.   Huang W#, Li N#, Zhang Y, Wang X, Yin M, Lei QY*. AHCYL1 Senses SAH to Inhibit Autophagy through Interaction with PIK3C3 in an mTORC1-independent Manner. Autophagy, 2022;18(2):309-319.

11.   Li JT#, Yang H#, Lei MZ#, Zhu WP#, Su Y, Li KY, Zhu WY, Wang J, Zhang L, Qu J, Lv L, Lu HJ, Chen ZJ, Wang L*, Yin M*, Lei QY*. Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA. Signal Transduct Target Ther. 2022;7(1):192.

12.   Pei X#, Li KY, Shen Y, Li JT, Lei MZ, Fang CY, Lu HJ, Yang HJ, Wen W, Yin M, Qu J*, Lei QY*. Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth. Sci China Life Sci. 2022;65(10):2017-2030.

13.   Li JT#, Li KY#, Su Y, Shen Y, Lei MZ, Zhang F, Yin M, Chen ZJ, Wen WY, Hu WG, Su D*, Qu J*, Lei QY*. Diet High in Branched-chain Amino Acid Promotes PDAC Development by USP1-mediated BCAT2 Stabilization. National Science Review. 2021;9(5):nwab212.

14.   Li JT#, Yin M#, Wang D#, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY*. BCAT2-mediated BCAA Catabolism is Critical for Development of Pancreatic Ductal Adenocarcinoma. Nature Cell Biology, 2020; 22: 161-174.doi.org/10.1038/s41556-019-0455-6. Highlight/Preview in Nature Cell Biology

15.   Lei, M.-Z. #, Li, X.-X., Zhang, Y., Li, J.-T., Zhang, F., Wang, Y.-P., Yin, M., Qu, J. *, and Lei, QY.* Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth. Signal transduction and targeted therapy, 2020; 5: 70.

16.   Liu Y#, Guo JZ#, Liu Y#, Wang K, Ding WC, Wang H, Liu X, Zhou ST, Lu XC, Yang HB, Xu CY, Gao W, Zhou L, Wang YP, Hu WG, Wei YQ, Huang CH*, Lei QY*. Nuclear Lactate Dehydrogenase A Senses ROS to Produce a-Hydroxybutyrate for HPV-Induced Cervical Tumor Growth. Nature Commun.2018; 9: 4429.doi: 10.1038/s41467-018-06841-724.

17.   Zhong XY#, Yuan XM, Xu YY, Yin M, Yan WW, Zou SW, Wei LM, Lu HJ, Wang YP*, Lei QY*. CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer. Cell Rep. 2018; 24(12):3207-3223. doi: 10.1016/j.celrep.2018.08.066.

18.   Xia S#, Lin R#, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Khuri FR, Boise LH, Lonial S, Lee BH, Pollack BP, Arbiser JL, Fan J*, Lei QY*, Chen J*. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism. 2017, 25(2):358-373. Highlight in Nature

19.   Zhang Y#, Xu YY#, Zhao XN, Li JT, Yang HB, Zhang M, Li, Yao CB, Yin M*, Chen J*, Lei QY*. Acetylation Targets HSD17B4 for Degradation via CMA Pathway in Response to E1. Autophagy. 2017, 13(3):538-553.

20.   Wang YP*，Wang J，Gao X, Xu YY, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell. 2016, 64, 673–687. Highlight in Cancer discovery

21.   Gao X#, Lin SH#，Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D， Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun. 2016, 7: 11960. doi: 10.1038/ncomms11960.

22.   Yang, HB#., Xu, YY#*., Zhao, XN, Zou SW*., Zhang Y., Zhang M., Li JT, Ren F., Wang LY., Lei QY*. Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer. Nature Commun. 2015, 6, 6973. doi: 10.1038/ncomms7973.

23.   Zha, ZY. #, Han, XR., Matthew D. Smith, Liu, Y., Patrick M. Giguère, DraganaKopanja, PradipRaychaudhuri, David P. Siderovski, Guan, KL*., Lei, QY.*, and Xiong, Y*. A Non- canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Molecular Cell. 2015; 58(5):794-803.

24.   Zhou, X#., Wang, SY#., Wang, Z., Feng, X., Liu, P., Lv, X-B., Li, F-L., Yu, F-x., Sun,YP., Yuan, HX., Zhu, HG., Xiong,Y*., Lei, QY*., Guan, KL*. Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma. J Clin Invest. 2015; 125(5):2123-35.

25.   Zhao, D. #, Mo, Y., Li, MT., Zou, SW., Cheng, ZL., Sun, Y-P., Xiong, Y*., Guan, KL*., Lei, QY*. NOTCH-induced Aldehyde Dehydrogenase 1A1 Deacetylation Promotes Breast Cancer Stem Cells. J Clin Invest. 2014; 124(12):5453-65.

26.   Li T, Liu F, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL, Xiong Y, Lei QY*. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J. Biol. Chem. 2014; 289(6):3775-85.

27.   Lv L#, Xu Y#, Zhao D, Li F, Wang W, Sasaki N, Jiang Y, Zhou X, Li T, Guan KL*, Lei QY*and Xiong Y*. Mitogenic and Oncogenic Stimulation of K433 Acetylation Promote PKM2 Protein Kinase Activity and Nuclear Localization. Molecular Cell. 2013; 52, 340–352. Highlights: Cover story in Molecular cell, Nature Reviews in Cancer, and Cancer discovery

28.   Lin R#, Ren T#, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP- citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell. 2013; 51, 506–518.

29.   Zhao D#, Zou S#, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*. Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell. 2013; 23, 464-476.

30.   Lv L#, Li D, Zhao D, Lin R, Chu Y，Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011; 42, 719-730. Highlights: Feature article Preview in Molecular Cell, Science Signaling, and Faculty of 1000

邀请综/评述:

1、Ming H#, Yin M*, Lei QY*. Spatio-temporal metabolic alterations in cachexia. Nat Metab. 2026;8(1):12–13.

2、Ma QX#, Yin M, Lei QY*. A nucleotide regulates NR4A1 status in gastric cancer. Mol Cell. 2025;85(23):4299-4300.

3、Yin M*, Lei QY*. Targeting stromal metabolism in pancreatic ductal adenocarcinoma. Nat Cell Biol. 2024;26(4):514-515.

4、Zhang Y#, Lei MZ, Yin M, Lei QY*. A metabolic clue for STING suppression. Trends Cell Biol. 2023;S0962-8924(23)00077-6.

5、Yin M*, Lei QY*. BCAT2-BCKDH metabolon maintains BCAA homeostasis. Nat Metab. 2022 ;4(12):1618-1619.

6、Qian L#, Zhang F#, Yin M*, Lei QY*. Cancer metabolism and dietary interventions. Cancer Biology & Medicine.2021;19(2):163-74.

7、Wang YP*, Li JT, Qu J, Yin M, Lei QY*. (2020). Metabolite sensing and signaling in cancer. Journal of Biological Chemistry, 295(33), 11938-11946.

8、Li JT#, Wang YP, Yin M*, Lei QY*. (2019). Metabolism remodeling in pancreatic ductal adenocarcinoma. Cell Stress; 3(12):361-368.

9、Wang YP*, Lei QY*. (2018). Metabolite sensing and signaling in cell metabolism. Signal Transduction and Targeted Therapy; 3:30.

10、Zhou X#, Lei QY*. (2016). Regulation of TAZ in cancer. Protein & Cell; 7(8):548-61.

11、Zhou X#, Wang Z, Huang W, Lei QY*. (2015). G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway. Acta Biochim Biophys Sin (Shanghai); (1):10-5.

12、Huang W#, Wang Z, Lei QY*. (2014). Acetylation control of metabolic enzymes in cancer: an updated version. Acta Biochim Biophys Sin (Shanghai); 46(3):204-13.

13、Lin R#, Zhou X, Huang W, Zhao D, Lv L, Xiong Y, Guan KL, Lei QY*. (2014). Acetylation control of cancer cell metabolism. Curr Pharm Des; (15):2627-33.

14、Zhao D#, Li FL, Cheng ZL, Lei QY*. (2014). Impact of acetylation on tumor metabolism. Mol Cell Oncol; 1(3):e963452.