
研究员,博士生导师
地址:徐汇区东安路131号科研二号楼,上海 200032
邮箱:LLSun@fudan.edu.cn
1. Bao, Z.; Liu, Z.; Zhang, Z.; Wang, X.; Jin, X.; Bai, J.; Ma, H.; Li, Y.; Yi, C.; Ling, Z.; Huang, Z.; Zhang, L.; Chen, Z.; Xie, Y.*; Wang, Y.*; Sun, L.*; Sun, X.*, Steric hindrance of antibody binding in an Omicron spike fusion intermediate. Nature 2026.
2. Han, L.; Mao, Q.; Zhu, J.; Jin, X.; Wang, X. D.; Liu, Z.; Upreti, N.; Wu, X.; Fang, Q.; Fokine, A.; Rao, V. B.*; Chen, Z*; Sun, L.* Cryo-EM structures of bacteriophage T4 portal-neck assembly intermediates reveal a viral genome retention mechanism. Nat Commun 2026, 17 (1).
3. Qiu Y, Sun L. Decoding WEEV's host adaptation. Cell Host Microbe 2025, 33(5): 610-612. (Preview)
4. Xing LX, Liu ZM, Wang XL, Liu QY, Xu W, Mao QY, Zhang X, Hao AH, Xia S, Liu ZZ, Sun LJ, Zhang GX, Wang Q, Chen ZG, Jiang SB*, Sun L*, Lu L*. Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target. Cell 2025, 188(5).
5. Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z*, Beutler B*, Sun L*. Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3(KBTBD2). Nat Struct Mol Biol 2024, 31(2): 336-350.
6. Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L*; Rao Z*; Yang H*. TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell 2024, 187(16): 4261-4271 e4217.
7. Wang Y, Hao A, Ji P, Ma Y, Zhang Z, Chen J, Mao Q, Xiong X, Rehati P, Wang Y, Wang Y, Wen Y, Lu L, Chen Z, Zhao J*; Wu F,*; Huang J,*; Sun L*. A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and Sarbecoviruses. Nat Commun 2024, 15(1): 5127.
8. Hao A, Song W, Li C, Zhang X, Tu C, Wang X, Wang P, Wu Y*, Ying T*, Sun L*. Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants. Signal Transduct Tar 2023, 8(1).
9. Ma Y, Mao Q, Wang Y, Zhang Z, Chen J, Hao A, Rehati P, Wang Y, Wen Y, Lu L, Chen Z, Zhao J*, Wu F*, Sun L*, Huang J*. A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity. Cell Res 2023.
10. Zhan W, Tian X, Zhang X, Xing S, Song W, Liu Q, Hao A, Hu Y, Zhang M, Ying T*, Chen Z*, Lan F*, Sun L*. Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer. J Virol 2022, 96(16): e0048022.
11. Li C, Zhan W, Yang Z, Tu C, Hu G, Zhang X, Song W, Du S, Zhu Y, Huang K, Kong Y, Zhang M, Mao Q, Gu X, Zhang Y, Xie Y, Deng Q, Song Y, Chen Z, Lu L, Jiang S, Wu Y*, Sun L*, Ying T*. Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell 2022, 185(8): 1389-1401 e1318.
12. Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J*, Wu F*, Sun L*, Huang J*. A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Res 2022, 32(9): 862-865.
13. Hu Y, Sun L*. Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses. ACS Infect Dis 2019, 5(7): 1070-1080.
14. Sun L#, Zhang X, Gao S, Rao PA, Padilla-Sanchez V, Chen Z, Sun S, Xiang Y, Subramaniam S, Rao VB*, Rossmann MG*. Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nat Commun 2015, 6: 7548.
15. Sun L#, Young LN, Zhang X, Boudko SP, Fokine A, Zbornik E, Roznowski AP, Molineux IJ, Rossmann MG*, Fane BA*. Icosahedral bacteriophage PhiX174 forms a tail for DNA transport during infection. Nature 2014, 505(7483): 432-435.
16. Sun L#, Rossmann MG*, Fane BA*. High-resolution structure of a virally encoded DNA-translocating conduit and the mechanism of DNA penetration. J Virol 2014, 88(18): 10276-10279.