博士,研究员,博士生导师
地址:东安路131号,上海 200032
电话: 021-54237501 (办公室)
邮件: wywen@fudan.edu.cn
1.Li J, Zhu K, Gu A, Zhang Y, Hu R, Hu W, Lei Q-Y, Wen W*. (2023) Feedback regulation of ubiquitination and phase separation of HECT E3 ligases. Proceedings of the National Academy of Sciences of the United States of America 120, e2302478120.
2.Xu J, Deng X, Gu A, Cai Y, Huang Y, Zhang W, Wen W*, Yunli Xie*. (2023) Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation. Cell Reports 42, 112677.
3.Li D, Huang S, Chai Y, Zhao R, Gong J, Zhang QC, Ou G*, Wen W*. (2023)A Paternal Protein Facilitates Sperm RNA Delivery to Regulate Zygotic Development. Science China-Life Sciences 66, 2342-2353.
4.Mayr C*, Mittag T*, Tang T-YD*, Wen W*, Zhang H*, Zhang H*. (2023) Frontiers in biomolecular condensate research. Nature Cell Biology 25, 512-514. (Invited viewpoint)
5.Zhang H*, Ji X*, Li P*, Liu C*, Lou J*, Wang Z, Wen W*, Xiao Y, Zhang M*, Zhu X*. (2020) Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases. Science China-Life Sciences63, 953-985. (Invited review)
6.Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y*, Wen W*. (2020) Par complex cluster formation mediated by phase separation. Nature Communications11, 2266.
7.Wang Z, Liu Z, Chen X, Li J, Yao W, Huang S, Gu A, Lei QY, Mao Y, Wen W*. (2019) A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.Nature Communications10, 3162.
8.Shan Z, Tu Y, Yang Y, Liu Z, Zeng M, Xu H, Long J, Zhang M, Cai Y*, Wen W*.(2018) Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nature Communications9, 737.
9.Yao W, Shan Z, Gu A, Fu M, Shi Z, Wen W*. (2018) WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex. Journal of Biological Chemistry293, 16697-16708.
10.Chen X, Liu Z, Shan Z, Yao W, Gu A, Wen W*.(2018) Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/α-adaptin complex. Journal of Biological Chemistry293, 4149-4158.
11.Zhu K, Shan Z, Chen X, Cai Y, Cui L, Yao W, Wang Z, Shi P, Tian C, Lou J, Xie Y, Wen W*. (2017) Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch. EMBO Report18, 1618-1630.
12.Zhu K, Shan Z, Zhang L, Wen, W*. (2016) Phospho-Pon binding mediated fine-tuning of Plk1 activity.Structure24, 1110-1119.
13.Jia M, Shan Z, Yang Y, Liu C, Li J, Luo ZG, Zhang M, Cai Y*, Wen W*, Wang W*. (2015) The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nature Communications6, 8381.
14.Pan Z, Shang Y, Jia M, Zhang L, Xia C, Zhang M, Wang W*, Wen W*. (2013) Structural and biochemical characterization of the interaction between LGN and Frmpd1. Journal of Molecular Biology425, 1039-1049.
15.Zhu J, Shang Y, Xia C, Wang W, Wen W*, Zhang M*. (2011) Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-protein-binding Modules EMBO Journal30, 4986-4997.
16.Liu W#, Wen W#, Wei Z, Yu J, Ye F, Liu CH, Hardie RC, Zhang M*. (2011) The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Cell145, 1088-1101. (#: co-first authors) (Cover article)
17.Zhu J#, Wen W#, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W*, Zhang M*. (2011) LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Molecular Cell43, 418-431. (#: co-first authors)
18.Wen W, Yu J, Pan L, Wei Z, Weng J, Wang W, Ong YS, Hoai TTT, Hong W, Zhang M*. (2010) Lipid-induced conformational switch controls fusion activity of longin domain SNARE Ykt6. Molecular Cell37, 383-395.