全聘课题组长
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  • 温文玉

    博士,研究员,博士生导师
    地址:东安路131号,上海 200032
    电话: 021-54237501 (办公室)
    邮件: wywen@fudan.edu.cn


工作经历
双聘研究员,复旦大学附属华山医院,神经外科(2016.6-今)
研究员,复旦大学,生物医学研究院(2012.12-今)
副研究员,复旦大学,生物医学研究院(2009.1-2012.11)
博士后,香港科技大学,生物化学系(2008.2-2008.12)
教育经历
博士,香港科技大学,生物化学系(2003.9-2008.1)
学士,复旦大学,化学系(1999.9-2003.7)
所获人才项目
国家优秀青年科学基金,国家自然科学基金,2014
新世纪优秀人才,教育部,2012
青年拔尖人才,上海市委组织部,2016
曙光学者,上海市教委,2014
青年科技启明星,上海市科委,2010
研究方向
聚焦蛋白质相分离与神经分化发育及病变的机制研究,在Cell、Nat Cell Biol、Mol Cell、EMBO J、Nat Commun、PNAS、J Cell Biol等国际专业期刊发表SCI论文50余篇。近期的主要发现为:1)相分离调控神经干细胞不对称分裂:提出相分离驱动命运决定因子时空性聚集进而介导细胞极化及子细胞信息传递的新概念;发现相分离凝聚体可突破经典复合物组装中的化学计量限制,容纳竞争性蛋白质共存,建立了复杂蛋白质网络动态构建的新理论;2)相分离紊乱与神经系统病变:阐明过量MBD2凝聚体的转录阻遏与促瘤机制,发现自噬调控因子的相分离缺陷或过度均会抑制自噬通路,加剧神经毒性蛋白及脂滴的聚集,揭示了相分离稳态的重要性。先后主持国家重大科学研究计划课题、国家重点研发计划课题、国家自然科学基金重大项目课题等。现任中国生物物理学会理事,中国细胞生物学会细胞结构与细胞行为专业分会副会长。
招生专业
生物化学与分子生物学
代表论文

1.WeiH, ZhengH, WangS, Yang Y, Zhao R, Gu A, Hu R, Lan F, Wen W*. Targeting redox-sensitive MBD2-NuRD condensate in cancer cells.Nature Cell Biology (in press) DOI:10.1038/s41556-025-01657-2.

2.Zhao R, Huang S, Li J, Gu A, Fu M, Hua W, Mao Y, Lei Q-Y, Lu B, Wen W*. Excessive STAU1 condensates drive mTOR translation and autophagy dysfunction in neurodegeneration. Journal of Cell Biology (2024) 223, e202311127.

3.Huang S, Fu M, Gu A, Zhao R, Liu Z, Hua W, Mao Y, Wen W*. mInsc coordinates Par3 and NuMA condensates for assembly of the spindle orientation machinery in asymmetric cell division. International Journal of Biological Macromolecules (2024)279, 135126.

4.Zhu K, Li J, Wen W*. Reply to Eichbichler et al.: Phase separation boosts HECT E3-mediated polyubiquitination. PNAS (2024)121, e2403169121.

5.Li J, Zhu K, Gu A, Zhang Y, Hu R, Hu W, Lei Q-Y, Wen W*. Feedback regulation of ubiquitination and phase separation of HECT E3 ligases. PNAS (2023) 120, e2302478120.

6.Xu J, Deng X, Gu A, Cai Y, Huang Y, Zhang W, Wen W*, Yunli Xie*. Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation. Cell Reports (2023) 42, 112677.

7.Li D, Huang S, Chai Y, Zhao R, Gong J, Zhang QC, Ou G*, Wen W*. A paternal protein facilitates sperm RNA delivery to regulate zygotic development. Science China-Life Sciences (2023) 66, 2342-2353.

8.Mayr C*, Mittag T*, Tang T-YD*, Wen W*, Zhang H*, Zhang H*. Frontiers in biomolecular condensate research. Nature Cell Biology(2023)25, 512-514. (Invited viewpoint)

9.Zhang H*, Ji X*, Li P*, Liu C*, Lou J*, Wang Z, Wen W*, Xiao Y, Zhang M*, Zhu X*. Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases. Science China-Life Sciences (2020) 63, 953-985. (Invited review)

10.Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y*, Wen W*. Par complex cluster formation mediated by phase separation. Nature Communications (2020) 11, 2266.

11.Wang Z, Liu Z, Chen X, Li J, Yao W, Huang S, Gu A, Lei QY, Mao Y, Wen W*. A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nature Communications (2019) 10, 3162.

12.Shan Z, Tu Y, Yang Y, Liu Z, Zeng M, Xu H, Long J, Zhang M, Cai Y*, Wen W*. Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nature Communications(2018) 9, 737.

13.Zhu K, Shan Z, Chen X, Cai Y, Cui L, Yao W, Wang Z, Shi P, Tian C, Lou J, Xie Y, Wen W*. Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch. EMBO Report(2017) 18, 1618-1630.

14.Jia M, Shan Z, Yang Y, Liu C, Li J, Luo ZG, Zhang M, Cai Y*, Wen W*, Wang W*. The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nature Communications (2015) 6, 8381.

15.Zhu J, Shang Y, Xia C, Wang W, Wen W*, Zhang M*. Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules. EMBO Journal(2011) 30, 4986-4997.


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