博士,研究员,博士生导师
地址:东安路131号,上海 200032
电话: 021-54237501 (办公室)
邮件: wywen@fudan.edu.cn
1.WeiH, ZhengH, WangS, Yang Y, Zhao R, Gu A, Hu R, Lan F, Wen W*. Targeting redox-sensitive MBD2-NuRD condensate in cancer cells.Nature Cell Biology (in press) DOI:10.1038/s41556-025-01657-2.
2.Zhao R, Huang S, Li J, Gu A, Fu M, Hua W, Mao Y, Lei Q-Y, Lu B, Wen W*. Excessive STAU1 condensates drive mTOR translation and autophagy dysfunction in neurodegeneration. Journal of Cell Biology (2024) 223, e202311127.
3.Huang S, Fu M, Gu A, Zhao R, Liu Z, Hua W, Mao Y, Wen W*. mInsc coordinates Par3 and NuMA condensates for assembly of the spindle orientation machinery in asymmetric cell division. International Journal of Biological Macromolecules (2024)279, 135126.
4.Zhu K, Li J, Wen W*. Reply to Eichbichler et al.: Phase separation boosts HECT E3-mediated polyubiquitination. PNAS (2024)121, e2403169121.
5.Li J, Zhu K, Gu A, Zhang Y, Hu R, Hu W, Lei Q-Y, Wen W*. Feedback regulation of ubiquitination and phase separation of HECT E3 ligases. PNAS (2023) 120, e2302478120.
6.Xu J, Deng X, Gu A, Cai Y, Huang Y, Zhang W, Wen W*, Yunli Xie*. Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation. Cell Reports (2023) 42, 112677.
7.Li D, Huang S, Chai Y, Zhao R, Gong J, Zhang QC, Ou G*, Wen W*. A paternal protein facilitates sperm RNA delivery to regulate zygotic development. Science China-Life Sciences (2023) 66, 2342-2353.
8.Mayr C*, Mittag T*, Tang T-YD*, Wen W*, Zhang H*, Zhang H*. Frontiers in biomolecular condensate research. Nature Cell Biology(2023)25, 512-514. (Invited viewpoint)
9.Zhang H*, Ji X*, Li P*, Liu C*, Lou J*, Wang Z, Wen W*, Xiao Y, Zhang M*, Zhu X*. Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases. Science China-Life Sciences (2020) 63, 953-985. (Invited review)
10.Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y*, Wen W*. Par complex cluster formation mediated by phase separation. Nature Communications (2020) 11, 2266.
11.Wang Z, Liu Z, Chen X, Li J, Yao W, Huang S, Gu A, Lei QY, Mao Y, Wen W*. A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nature Communications (2019) 10, 3162.
12.Shan Z, Tu Y, Yang Y, Liu Z, Zeng M, Xu H, Long J, Zhang M, Cai Y*, Wen W*. Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nature Communications(2018) 9, 737.
13.Zhu K, Shan Z, Chen X, Cai Y, Cui L, Yao W, Wang Z, Shi P, Tian C, Lou J, Xie Y, Wen W*. Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch. EMBO Report(2017) 18, 1618-1630.
14.Jia M, Shan Z, Yang Y, Liu C, Li J, Luo ZG, Zhang M, Cai Y*, Wen W*, Wang W*. The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nature Communications (2015) 6, 8381.
15.Zhu J, Shang Y, Xia C, Wang W, Wen W*, Zhang M*. Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules. EMBO Journal(2011) 30, 4986-4997.