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  • 温文玉

    博士,研究员,博士生导师
    地址:东安路131号,明道楼 915室,上海 200032
    电话:  021-54237501 (办公室),021-54237502 (实验室)
    邮件:  wywen@fudan.edu.cn


工作经历
兼职教授 复旦大学附属华山医院,神经外科(2016.6-今)
研究员 复旦大学,生物医学研究院(2012.12-今)
副研究员 复旦大学,生物医学研究院(2009.1-2012.11)
博士后 香港科技大学,生物化学系(2008.2-2008.12)
教育经历
博士,香港科技大学,生物化学系(2003.9-2008.1)
学士,复旦大学,化学系(1999.9-2003.7)
所获人才项目
国家优秀青年科学基金,国家自然科学基金,2014
新世纪优秀人才,教育部,2012
青年拔尖人才,上海市委组织部,2016
曙光学者,上海市教委,2014
青年科技启明星,上海市科委,2010
研究方向
围绕神经干细胞早期发育过程中的核心问题,综合生物化学、生物物理学、细胞生物学及模式生物等多学科手段,揭示神经干细胞不对称分裂、神经元分化迁移以及神经信号传导过程的分子机制,以期为神经元生理过程的调控及相关神经系统疾病(如脑肿瘤)的防治研究提供新的策略。在Cell(封面文章), Mol Cell(2篇), Nat Commun(4篇), EMBO J(2篇)等国际专业期刊发表第一或通讯作者SCI论文26篇。在复旦大学工作期间,比较系统地研究了神经干细胞不对称分裂过程中,细胞命运决定因子极性分布的分子机制以及纺锤体转向系统的动态组装机理,提出蛋白质相分离调控细胞极化过程的新理念(Mol Cell, 2010;Mol Cell, 2011;EMBO J, 2011;J Mol Biol, 2013;Nat Commun, 2015;Structure, 2016;J Mol Biol, 2018;Nat Commun, 2018;Nat Commun, 2020);初步探讨了神经元分化和迁移过程中Nedd4家族泛素连接酶的作用及其活性调控机制(EMBO Rep, 2017;J Biol Chem, 2018a;J Biol Chem, 2018b;Nat Commun, 2019);提出了支架蛋白在信号刺激下可以主动调节自身氧化还原电势进而介导信号传导过程的新机制(Cell, 2011, 封面文章)。主持国家及省部级项目10余项,含国家重大科学研究计划课题1项、国家重点研发计划课题1项、国家自然科学基金项目5项。
代表论文

1.Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y*, Wen W*. (2020) Par complex cluster formation mediated by phase separation. Nature Communications 11, 2266.

2.Wang Z, Liu Z, Chen X, Li J, Yao W, Huang S, Gu A, Lei QY, Mao Y, Wen W*. (2019) A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nature Communications 10, 3162.

3.Shan Z, Tu Y, Yang Y, Liu Z, Zeng M, Xu H, Long J, Zhang M, Cai Y*, Wen W*. (2018) Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nature Communications 9, 737.

4.Yao W, Shan Z, Gu A, Fu M, Shi Z, Wen W*. (2018) WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex. Journal of Biological Chemistry 293, 16697-16708.

5.Chen X, Liu Z, Shan Z, Yao W, Gu A, Wen W*. (2018) Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/α-adaptin complex. Journal of Biological Chemistry 293, 4149-4158.

6.Zhu K, Shan Z, Chen X, Cai Y, Cui L, Yao W, Wang Z, Shi P, Tian C, Lou J, Xie Y, Wen W*. (2017) Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch. EMBO Report 18, 1618-1630.

7.Zhu K, Shan Z, Zhang L, Wen, W*. (2016) Phospho-Pon binding mediated fine-tuning of Plk1 activity. Structure 24, 1110-1119.

8.Jia M, Shan Z, Yang Y, Liu C, Li J, Luo ZG, Zhang M, Cai Y*, Wen W*, Wang W*. (2015) The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nature Communications 6, 8381.

9.Pan Z, Shang Y, Jia M, Zhang L, Xia C, Zhang M, Wang W*, Wen W*. (2013) Structural and biochemical characterization of the interaction between LGN and Frmpd1. Journal of Molecular Biology 425, 1039-1049.

10.Zhu J, Shang Y, Xia C, Wang W, Wen W*, Zhang M*. (2011) Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-protein-binding Modules EMBO Journal 30, 4986-4997.

11.Liu W#, Wen W#, Wei Z, Yu J, Ye F, Liu CH, Hardie RC, Zhang M*. (2011) The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Cell 145, 1088-1101. (#: co-first authors) (Cover article)

Highlights: F1000, http://f1000.com/prime/12082956

12.Zhu J#, Wen W#, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W*, Zhang M*. (2011) LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Molecular Cell 43, 418-431. (#: co-first authors) 

13.Wen W, Yu J, Pan L, Wei Z, Weng J, Wang W, Ong YS, Hoai TTT, Hong W, Zhang M*. (2010) Lipid-induced conformational switch controls fusion activity of longin domain SNARE Ykt6. Molecular Cell 37, 383-395.

Highlights: F1000, http://f1000.com/prime/2939958


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