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  • 张晓燕

    博士生导师,复旦大学附属上海市公共卫生临床中心双聘教授
    地址:上海市金山区漕廊公路2901号科研楼308室
    电话:021-37990333转7310
    邮箱:zhangxiaoyan@shphc.org.cn
    实验室主页:http://www.hiv.fudan.edu.cn

工作经历
研究员,复旦大学,生物医学研究院(2008.7-今)
研究员,中国疾病预防控制中心艾滋病预防控制中心(2007.10-2008.6)
副研究员,中国疾病预防控制中心艾滋病预防控制中心(2002.8-2007.9)
博士后,美国纽约大学医学院(2000.1–2002.7)
助理教授,日本东北大学医学部(1999.4–2000.1)
教育经历
医学学士与硕士,哈尔滨医科大学(1984.9-1993.7)
医学博士,日本京都大学(1995.4-1999.3)
所获人才项目
2010年,入选上海市优秀学科带头人
2011年,入选上海市医学领军人才
所获奖项
2011年,黏膜潜在免疫损伤预测的新技术。上海医学科技奖三等奖(第一完成人)
研究方向
我团队研究了粘膜传播的HIV-1的特征及其与粘膜免疫的相互作用。通过体外建立小鼠生殖道粘膜炎症模型和人粘膜活组织模型,复制HIV粘膜感染的生物学轨迹,发现粘膜局部使用的候选杀微生物剂可以诱导特定的T细胞反应和炎症反应,进而影响具有病毒感染 。 研究结果有助于改善包括杀微生物剂在内的生物干预技术的安全性评价体系,避免引起局部免疫微环境失衡,增加微生物感染的风险。 团队还研究了HIV-1潜在感染的机制,发现TSC1和DEPDC5通过mTOR信号通路调节HIV-1潜伏期。
与此同时,团队对高致病性流感病毒在呼吸道粘膜感染过程中免疫反应的失衡以及宿主的限制因素展开研究,描述了TFF2的功能和机制,解决了在流感病毒感染期间急性期IFN-κ发挥的作用。
自2014年以来,张教授团队参与了肿瘤免疫疗法的临床研究。“NKT联合PD1 + CD8细胞治疗肿瘤”这一主要项目对控制肺癌,胰腺癌和其他晚期肿瘤患者的疾病进展显示出显著作用,患者的整体临床受益率为50-60%,有效地延长了生存期,提高了患者的生活质量。
作为PI,张教授累计获得省部级以上科研项目25项以上,包括国家自然科学基金、国家传染病控制重大专项、973等(累计超过5000万元人民币),发表了100多篇SCI论文,包括 Nature, Nature Microbiology, Nature Communications, Proc Natl Acad Sci U S A., Journal of Immunology, Journal of Virology, Emerging Microbes & Infections, Clinical Infectious Diseases, J Infect Dis. Vaccine, AIDS 等。

代表论文

1.Shan Jin, Qibin Liao, Jian Chen, Linxia Zhang, Qian He, Huanzhang Zhu, Xiaoyan Zhang*Jianqing Xu* .TSC1 and DEPDC5 regulate HIV-1 latency through the mTOR signaling pathway. Emerging Microbes & Infections. 138 (2018)https://doi.org/10.1038/s41426 -018-0139-5.

2.Jian Chen#, Yi-feng Yang#, Yu Yang, Peng Zou, Yongquan He, Sai-lan Shui, Jun Chen, Ru Bai, Ya-jun Liang, Yunwen Hu, Biao Jiang, Lu Lu, Xiaoyan Zhang*, Jia Liu*, Jianqing Xu*.  AXL Promotes Zika Virus Infection in Astrocytes by Antagonizing Type I Interferon Signaling Pathway. Nature microbiology. 2018 Jan 29. doi: 10.1038/s41564-017-0092-4.

3.         Hillary A Vanderven#, Lu Liu#, Fernanda Ana-Sosa-Batiz, Thi HO Nguyen, Yanmin Wan, Bruce Wines, P Mark Hogarth, Danielle Tilmanis, Arnold Reynaldi, Matthew S Parsons, Aeron C Hurt, Miles P Davenport, Tom Kotsimbos, Allen C Cheng, Katherine Kedzierska, Xiaoyan Zhang*, Jianqing Xu* and Stephen J Kent* Fc functional antibodies during severe human H7N9 and seasonal influenza. JCI Insight 2017; 2(13): e92750. https://doi.org/10.1172/jci.insight.92750.

4.Liu L#, Nachbagauer R#, Zhu L, Huang Y, Xie X, Jin S, Zhang A, Wan Y, Hirsh A, Tian D, Shi X, Dong Z, Yuan S, Hu Y, Krammer F*, Zhang X*, Xu J*. Induction of Broadly Cross-Reactive Stalk-Specific Antibody Responses to Influenza Group 1 and Group 2 Hemagglutinins by Natural H7N9 Virus Infection in Human. J Infect Dis. 2017 Feb 15;215(4):518-528. doi: 10.1093/infdis/jiw608.

5.         Yu Yang, Jingyu Zhu, Matthew Hassink, Lisa M. Miller Jenkins, Yanmin Wan, Daniel H. Appella, Jianqing Xu, Ettore Appella,*, Xiaoyan Zhang,* A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion. Emerging Microbes & Infections. 2017. Jun 7;6(6):e40. doi: 10.1038/emi.2017.26.

6.Jun Huang, Lingyan Zhu, Chao Qiu, Xuan Xu, Linxia Zhang, Xiangqing Ding, Qibin Liao, Jianqing Xu*, Xiaoyan Zhang*. MiR-126-5p enhances the inflammatory response of monocytes to LPS through suppressing CYLD in chronic HIV-1 infection. Journal of Virology. 2017 Mar 1. pii: JVI.02048-16. doi: 10.1128/JVI.02048-16.

7.Xiaoling Tian, Anli Zhang, Chao Qiu, Wei Wang, Yu Yang, Chenli Qiu, Aiping Liu, Linyan Zhu, Songhua Yuan, Huiliang Hu, Wanhai Wang, Qiang Wei, Xiaoyan Zhang* and Jianqing Xu. The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlateswith Disease Progression in HIV-Infected Subjects. The Journal of Immunology, 2015, Apr 15; 194 (8): 3873-82.

8.Zhongfang Wang , Anli Zhang , Yanmin Wan , Xinian Liu , Chao Qiu , Xiuhong Xi , Yanqin Ren , Jing Wang , Yuan Dong , Meijuan Bao , Liangzhu Li , Mingzhe Zhou , Songhua Yuan , Jun Sun , Zhaoqin Zhu , Liang Chen , Qingsheng Li , Zhiyong Zhang , Xiaoyan Zhang* , Shuihua Lu , Peter C Doherty, Katherine Kedzierska , Jianqing Xu. Early hypercytokinemia is associated with IFITM3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci U S A. 2014 Jan 14; 111 (2): 769-74.

9.Wei Zhang, Li Xu, Hae-Bin Park, Juyoung Hwang, Minseok Kwak, Peter C. W. Lee, Guang Liang, Xiaoyan Zhang, jianqing Xu, and Jun-O Jin. Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy. Nature Communications. 2020 Mar 4;11(1):1187. doi: 10.1038/s41467-020-15030-4.

10.Wei Zhang, Li Xu; Xiaoyan Zhang; Jianqing Xu, Jun-O Jin. CD8α conventional dendritic cells control Vβ T cell immunity in response to Staphylococcus aureus infection in mice.  Immunology. Published: 07 January 2020. https://doi.org/10.1111/imm.13171

11.Tianyi Qiu, Yiyan Yang, Jingxuan Qiu, Yang Huang, Tianlei Xu, Han Xiao, Dingfeng Wu, Qingchen Zhang, Chen Zhou, Xiaoyan Zhang, Kailin Tang, Jianqing Xu, and Zhiwei Cao. CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens. Nature Communication. 2018 May 2;9(1):1772. doi: 10.1038/ s41467 -018-04171-2.

12.Zhongfang Wang , Lingyan Zhu , Thi H O Nguyen , Yanmin Wan , Sneha Sant , Sergio Quiñones-Parra , Jeremy Chase Crawford , Auda Eltahla , Simone Rizzetto , Rowena Bull , Chenli Qiu , Marios Koutsakos , Ella Clemens , Liyen Loh , Tianyue Chen , Lu Liu , Pengxing Cao , Yanqin Ren , Lukasz Kedzierski , Tom Kotsimbos , James McCaw , Nicole La Gruta , Stephen Turner , Allen Cheng , Fabio Luciani , Xiaoyan Zhang , Peter Doherty , Paul Thomas , Jianqing Xu* and Katherine Kedzierska*. Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease. Nature Communication. (2018) 9:824. DOI: 10.1038/s41467-018-03243-7.

13.Ran He, Shiyue Hou, Cheng Liu, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Jianqing Xu, Hai Qi*, Yuzhang Wu* and Lilin Ye*. Follicular CXCR5-expressing CD8 T cells curtail chronic viral infection. Nature, 2016 Aug 2;537(7620):412-428. doi: 10.1038/nature19317.

14.Zhongfang Wang, Yanmin Wan, Chenli Qiu1, Sergio Quiñones-Parra, Zhaoqin Zhu, Liyen Loh, Di Tian1, Yanqin Ren1, Yunwen Hu1, Xiaoyan Zhang, Paul G Thomas, Michael Inouye, Peter C Doherty, Katherine Kedzierska*, Jianqing Xu*. Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells. Nature Communications, 2015 May 13;6:6833. doi: 10.1038/ncomms7833 .

15.Xuan Xu, Chao Qiu, Lingyan Zhu, Jun Huang, Lishuang Li, Weihui Fu, Linxia Zhang, Jun Wei, Ying Wang, Yunqi Geng, Xiaoyan Zhang, Wentao Qiao, Jianqing Xu. IFN-Stimulated Gene LY6E in Monocytes Regulates the CD14/TLR4 Pathway but Inadequately Restrains the Hyperactivation of Monocytes during Chronic HIV-1 Infection. The Journal of Immunology. 2014 Oct 15; 193(8): 4125


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