全聘课题组长
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  • 周玉峰

    博士,研究员,博士生导师,复旦大学附属儿科医院兼职教授
    地址:徐汇区东安路131号,科研二号楼A座CB2-025室,上海200032;闵行区万源路399号,复旦大学附属儿科医院8号楼6楼607室,201102
    电话:021-64932907(办公室)
    邮箱:yfzhou1@fudan.edu.cn


工作经历
2015/6-至今,复旦大学生物医学研究院,研究员
2015/6-至今,复旦大学附属儿科医院,研究员(双聘PI)
2015/5-2019/7,美国约翰霍普金斯大学,医学系,兼职助理教授
2011/7-2015/5,美国约翰霍普金斯大学,医学系,讲师
2007/12-2011/6,美国约翰霍普金斯大学,医学系,博士后
2006/9-2007/11,美国杜克大学,肿瘤和免疫系,助理研究员
2000/7-2003/7,深圳市儿童医院,医师
教育经历
2003/9-2006/6,华中科技大学,儿科学,博士
1997/9-2000/6,华中科技大学,儿科学,硕士
1992/9-1997/7,潍坊医学院,临床医学,学士
所获人才项目
上海市医学领军人才,上海市卫计委,2019
所获奖项
重庆市科技进步三等奖,重庆市人民政府,2004
广东省科技进步二等奖,广东省人民政府,2019
深圳市科技进步二等奖,深圳市人民政府,2019
中华医学会儿科分会第二届高影响力论文奖,2020
中华医学会呼吸病学分会2020高影响力论文奖,2020
研究方向
主要研究环境和表观遗传学因素对免疫系统发育和功能的影响,包括哮喘和过敏性疾病、自身免疫性疾病、感染与炎症、肿瘤性疾病的免疫学发病机制和防治研究。研究方向包括①非编码RNA与免疫调节;②环境和表观遗传学因素对免疫系统发育及功能的影响;③代谢重编程与免疫调节;④肿瘤免疫学,主要研究髓母细胞瘤、神经胶质瘤的免疫学发病机制及治疗; ⑤免疫性疾病的细胞与基因治疗。主持国家自然科学基金面上项目、科技部国家重点研发计划(课题组长)等项目。担任Allergy,Pediatrics 等20种英语杂志的编辑或审稿专家。在Nature Medicine、Blood、The Journal of Allergy and Clinical Immunology(5篇)和Science Advances等发表论文70余篇。

代表论文

1.Yang L#, Fu J#, Han X#, Zhang C#, Xia L, Zhu R, Huang S, Xiao W, Yu H, Gao Y, Liang Q, Li W*, Zhou Y*. Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis. J Allergy Clin Immunol. 2021 Dec 22:S0091-6749(21)02685-3. doi: 10.1016/j.jaci.2021.11.024. Online ahead of print.

2.Xue P#, Huang S#, Han X#, Zhang C, Yang L, Xiao W, Fu J, Li H*, Zhou Y*. Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2.Cell Death Differ. 2021 Jul 22. doi: 10.1038/s41418-021-00838-4. Online ahead of print.

3.Yang L, Xie X, Tu Z, Fu J, Xu D*, Zhou Y*. The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduct Target Ther. 2021 Jul 7;6(1):255. doi: 10.1038/s41392-021-00679-0.

4.Xia L#, Wang X#, Liu L#, Fu J#, Xiao W, Liang Q, Han X, Huang S, Sun L, Gao Y, Zhang C, Yang L, Wang L, Qian L*, Zhou Y*. lnc-BAZ2B promotes M2 macrophage activation and inflammation in children with asthma through stabilizing BAZ2B pre-mRNA. J Allergy Clin Immunol 2021; 147:921-32 e9.

5.Zhang C#, Han X#, Yang L#, Fu J#, Sun C, Huang S, Xiao W, Gao Y, Liang Q, Wang X, Luo F, Lu W, Zhou Y*. Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. Theranostics 2020; 10:10908-24.

6.Yang L#, Han X#, Zhang C#, Sun C#, Huang S, Xiao W, Gao Y, Liang Q, Luo F, Lu W, Fu J*, Zhou Y*. Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus. Front Immunol 2020; 11:576903.

7.Yang L, Fu J, Zhou Y*. Research Progress in Atopic March. Front Immunol 2020; 11:1907.

8.Sun L#, Fu J#, Lin SH#, Sun JL#, Xia L, Lin CH, Liu L, Zhang C, Yang L, Xue P, Wang X, Huang S, Han X, Chen HL, Huang MS, Zhang X, Huang SK, Zhou Y*. Particulate matter of 2.5 mum or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1alpha in an asthma model. J Allergy Clin Immunol 2020; 145:402-14.

9.Huang S#, Xue P#, Han X#, Zhang C, Yang L, Liu L, Wang X, Li H, Fu J*, Zhou Y*. Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis. Cell Death Dis 2020; 11:408.

10.Zhang C, Fu J, Zhou Y*. A Review in Research Progress Concerning m6A Methylation and Immunoregulation. Front Immunol 2019; 10:922.

11.Yu J#, Luo Y#, Zhu Z#, Zhou Y#, Sun L, Gao J, Sun J, Wang G, Yao X*, Li W*. A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor. J Allergy Clin Immunol 2019; 143:2108-19 e12.

12.Han X#, Huang S#, Xue P#, Fu J#, Liu L, Zhang C, Yang L, Xia L, Sun L, Huang SK, Zhou Y*. LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE. Science Advances 2019; 5:eaax9230.

13.Zhou Y, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK*, Gao P*. Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p. J Allergy Clin Immunol 2018; 141:350-64 e8.

14.Yang L, Fu J, Zhou Y*. Circular RNAs and Their Emerging Roles in Immune Regulation. Front Immunol 2018; 9:2977.

15.Xue P, Fu J, Zhou Y*. The Aryl Hydrocarbon Receptor and Tumor Immunity. Front Immunol 2018; 9:286.

16.Wang HC#, Zhou Y#, Huang SK*. SHP-2 phosphatase controls aryl hydrocarbon receptor-mediated ER stress response in mast cells. Arch Toxicol 2017; 91:1739-48.

17.Sun L, Fu J, Zhou Y*. Metabolism Controls the Balance of Th17/T-Regulatory Cells. Front Immunol 2017; 8:1632.

18.Xu T#, Zhou Y#, Qiu L, Do DC, Zhao Y, Cui Z, Wang H, Liu X, Saradna A, Cao X, Wan M, Gao P*. Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen-Induced Inflammation by Modulating Mesenchymal Stem Cells. J Immunol 2015; 195:5539-50.

19.Gao P#*, Zhou Y#, Xian L, Li C, Xu T, Plunkett B, Huang SK, Wan M, Cao X. Functional Effects of TGF-beta1 on Mesenchymal Stem Cell Mobilization in Cockroach Allergen-Induced Asthma. J Immunol 2014; 192:4560-70.

20.Zhou Y, Tung HY, Tsai YM, Hsu SC, Chang HW, Kawasaki H, Tseng HC, Plunkett B, Gao P, Hung CH, Vonakis BM, Huang SK*. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood 2013; 121:3195-204.

21.Zhou Y#, Kawasaki H#, Hsu SC, Lee RT, Yao X, Plunkett B, Fu J, Yang K, Lee YC, Huang SK*. Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nature Medicine 2010; 16:1128-33.

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