胡治祥

发表时间:2022-02-11  |  阅读次数:12594次  |  字体大小 [ 小 中 大 ]
  • 胡治祥

    博士,副研究员
    地址:东安路270号
    邮箱:zhixiang_hu@fudan.edu.cn

工作经历
副研究员,复旦大学,生物医学研究院(2025-12至今)
青年副研究员,复旦大学,生物医学研究院(2021-11-2025-12)
博士后,复旦大学附属肿瘤医院(2019-07至2021-10)
教育经历
博士,生物化学与分子生物学,复旦大学(2014.09-2019.06)
学士,生物科学,上海师范大学(2010.09-2014.06)
研究方向
肿瘤特异转录本的基础和转化研究:1、明确肿瘤特异转录本的特征、生物学功能和促癌机制;2、鉴定具有转化潜力的促癌靶点,并开发相应的治疗手段(小分子抑制剂,RNA药物如肿瘤新抗原mRNA疫苗)。
代表论文

1.Ying Su*, Ziteng Li*, Qin Li*, Xinyi Guo, Hena Zhang, Yan Li , Zhiqiang Meng#, Shenglin Huang#, Zhixiang Hu#. Oncofetal TRIM71 drives liver cancer carcinogenesis through remodeling CEBPA-mediated serine/glycine metabolism. Theranostics. 2024.14(13):4948-4966. doi: 10.7150/thno.99633.

2. Qin Li*, Ziteng Li*, Bing Chen, Jingjing Zhao, Hongwu Yu, Jia Hu, Hongyan Lai, Hena Zhang, Yan Li, Zhiqiang Meng, Zhixiang Hu#, Shenglin Huang#. RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer.Cell Reports. 2024. 43(11):114893. doi: 10.1016/j.celrep.2024.114893.

3. Zhixiang Hu*, Xinyi Guo, Ziteng Li, Zhiqiang Meng#, Shenglin Huang#. The neoantigens derived from transposable elements - A hidden treasure for cancer immunotherapy. Biochim Biophys Acta Rev Cancer. 2024. 1879(5):189126. doi: 10.1016/j.bbcan.2024.189126.

4. Xinrong Li*, Zhixiang Hu*, Qili Shi, Wenying Qiu, Yizhe Liu, Yanfang Liu, Shenglin Huang, Linhui Liang, Zhiao Chen#, Xianghuo He#. Elevated choline drives KLF5-dominated transcriptional reprogramming to facilitate liver cancer progression.Oncogene. 2024. 43(42):3121-3136.  doi: 10.1038/s41388-024-03150-w.

5. Yong Wu*, Siyu Chen*, Yang Shao*, Ying Su, Qin Li, Jiangchun Wu, Jun Zhu, Hao Wen, Yan Huang, Zhong Zheng, Xiaojun Chen, Xingzhu Ju, Shenglin Huang#, Xiaohua Wu#, Zhixiang Hu#. KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer.Advanced Science. 2023. 10(31):e2304638. doi: 10.1002/advs.202304638.

6. Qin Li*, Hongyan Lai*, Yuchen Li, Bing Chen, Siyuan Chen, Yan Li, Zhaohui Huang, Zhiqiang Meng, Peng Wang, Zhixiang Hu#, Shenglin Huang#. RJunBase: a database of RNA splice junctions in human normal and cancerous tissues. Nucleic Acids Resarch. 2021.  49(D1):D201-D211. doi: 10.1093/nar/gkaa1056.

7. Zhixiang Hu*, Liangqing Dong *, Shengli Li, Zhe Li, Yejun Qiao, Yuchen Li, Jie Ding, Zhiao Chen, Yangjun Wu, Zhen Wang, Shenglin Huang, Qiang Gao #, Yingjun Zhao#, Xianghuo He#. Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hepatology. 2020 Aug;72(2):548-568. doi: 10.1002/hep.31062.

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