第四届发育和疾病的表观遗传学上海国际研讨会通知
第四届发育和疾病的表观遗传学上海国际研讨会 ”将于2018年9月18日-21日在上海中山医院举办。
表观遗传学 (Epigenetics) 是论及决定细胞时代间基因组 转录记忆 的与 DNA 序列改变无关的信号, 介导者和机制的学科。表观遗传事件通过对 DNA 和组蛋白的 共价修饰 , 以转录的 RNA 和翻译的蛋白的方式, 调节和功能化地展示编码在 DNA 序列中遗传的结构信息, 继而产生在 时空多维空间 无限多样的表型。健康表观遗传稳态是确保高等生物发育过程中细胞分化和谱系化正常开展所依据的优态基因组表达的必要前提。基因组表观遗传信息界面的异常是包括肿瘤, 代谢类和神经系统疾病在内的疾患的病因, 病理学机制之一。
为了加大本次大会学术交流的力度, 除了 6 个主题 /26 个 25 分钟报告以外, 我们还安排了 28 个 10 分钟报告, 后者是从两个时长 1.5 小时的墙报摘要者中遴选出来的。欢迎各位与会者积极报名并提交墙报摘要！
会议主题：
主题 1. DNA 修饰的化学和生物学
主题 2. 组蛋白修饰的化学和生物学
主题 3. 转录的化学生物学和表观调控
主题 4. 临床表观遗传学
主题 5. 染色质高级结构的化学和生物学
主题 6. 发育的表观遗传学
报名参会
演讲嘉宾：
大会日程：
| 18th, Sept, 2018 13:00-17:30 会前会 | ||
| DNA 甲基化专题研讨会 | ||
| 13:00-14:00 | 会议注册 | |
| 14:00-14:30 | DNA 甲基化在皮肤病研究中的进（TBD） | 张学军教授安徽医科大学 |
| 14:30-15:00 | DNA 甲基化在液体活检中的应用 | 戴珩 博士中科普瑞 CTO |
| 15:00-15:30 | 甲基化在鼻咽癌中的预后作用及机制研究 | 柳娜 博士（马骏教授团队）中山大学肿瘤防治中心 |
| 15:30-15:50 | 茶歇 | |
| 15:50-16:20 | Epigenome-wide association study identifies Behcet's disease-associated methylation loci in Han Chinese | 于红松 教授遵义医学院 |
| 16:20-17:00 | 后基因组时代下的甲基化多组学研究策略 | 李明辉 博士表观星图计划首席科学家中科普瑞科研服务技术产品总监 |
| 17:00-17:30 | 互动讨论：表观星图项目 | 朱景德、张学军、柳娜、于红松、戴珩、李明辉 |
| 19th, Sept, 2018 | ||
| 8:30-8:40 | Opening | |
| I. Chemical and Biological Perspectives of DNA Modifications | ||
| Chair of the first half part: Kazu Ushijima (Tokyo) | ||
| 8:40-9:05 | A vitamin C-derived DNA modification | Guoliang Xu (Academia Sinica, Shanghai) |
| 9:05-9:25 | Aging, epigenetic clocks and cancer risk | Andrew Teschendorff |
| 9:25-9:50 | Active DNA Demethylation by Vertebrate DNA Methyltransferases | James Shen (AcademiaSinica, Taipei) |
| 9:50-10:00 | The DNA modification landscape of human genome： an experience of HuaXia1 genome/Third-Generation Sequencing. | Depeng Wang （Grandomics Biosciences） |
| 10:00-10:10 | N6-Methyladenine DNA Modification in the Human Genome | Chuanle Xiao (Zhongshan Univerisity) |
| 10:10-10:35 | Break+Group Photograph | |
| Chair of the second half part: Fei Lan (FuDan University) | ||
| 10:35-11:00 | Structural Insight into dynamic regulation of DNA methylation | Yanhui Xu (FudanUniversity) |
| 11:00-11:25 | DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA asDiagnostic Biomarkers for Human Cancers | Xingyu Lu (Shanghai) |
| 11:25-11:35 | Bisulfite-free, nano-scale analysis of 5-hydroxymethylcytosine at single base resolution. | Hu Zeng（Peking University） |
| 11:35-11:45 | BRIF-seq: bisulfite-converted randomly integrated fragments sequencing at single cell level | Xiang Li(Huazhong Agricultural University) |
| 11:45-11:55 | The role of differentially methylated regions in normal hematopoiesis and leukemogenesis | Pengxu Qian (Zhejiang Univerisity) |
| 11:55-13:00 | Lunch | |
| 13:00-14:30 | Poster session Chair: Guohong Li | |
| 14:30-14:40 | Decoding the epigenetic landscape by the histone readers: implications in human diseases | Chandrima Das |
| 14:40-14:50 | Epigenome reprogramming as a basis for combination therapy | Naoko Hattori |
| II.Chemical and Biological Perspectives of histone modifications | ||
| Chair of the first half part : Youngjun Kim(Korea, Seul) | ||
| 14:50-15:15 | Structure and Function of YEATS Domain in Health and Disease | Haitao Li (TsinghuaUniversity)， |
| 15:15-15:40 | The Dynamic Regulation of Histone Methylation | Fei Lan (Fudan University) |
| 15:40-16:05 | De-acetylation and Epigenomic regulation | Ullas Kolthur-Seetharam （Tata Institute， India） |
| 16:05-16:30 | Metabolic regulation of gene expression | Zhimin Lu (MD Anderson) |
| 16:30-16:50 | Tea Break | |
| Chair of the second half part: Lijung Juan(Academia Sinica, Taipei) | ||
| 16:50-17:15 | Epgenetics and Adipogenesis: Implications of Histone modificationsLanguages | Tapas K. Kundu (India) |
| 17:15-17:25 | UTX functions as an escape from X-inactivation tumor-suppressor in B cell lymphoma | Hai Jiang（Academica Sinica, Shanghai） |
| 17:25-17:35 | Discovery and Functional Insight of a SIRT6 Allosteric | Xiuyan Yang (Shanghai Jiao Tong University School of Medicine) |
| 20th, Sept, 2018 | ||
| III. Chemical and epigenetic regulation of transcription | ||
| Chair of the first half part: Shyam PRABHAKAR (Singapore) | ||
| 8:30-8:55 | R-loopsin physiology and pathology | Xiangdong Fu (UCSD) |
| 8:55-9:20 | Epigenetic Regulation of Hematopoietic Stem Cell Development | Feng Liu (AcademiaSinica, Beijing) |
| 9:20-9:50 | The Diversity and Function of Long Noncoding RNAs | Lingling Chen (AcademiaSinica,Shanghai) |
| 9:50-10:15 | Cis-acting lncRNAs in transcription and chromatin regulation | Xiaohua Shen (TsinghuaUniversity) |
| 10:15-10:40 | Tea Break | |
| Chair of the second half part: Hongkui Deng(Peking University) | ||
| 10:40-11:05 | R-loop, the general chromatin feature in Arabidopsis genomes | Qianwen Sun (TsinghuaUniversity) |
| 11:05-11:30 | Re-thinking the coding capacity of non-coding RNA | Zefeng Wang (AcademiaSinica，Shanghai) |
| 11:30-11:40 | A long noncoding RNA in telomere maintenance, gene regulation andinter-chromosomal pairing | Hsueh-Ping Chu(National TaiwanUniversity) |
| 11:40-11:50 | Single-cell Landscape during Cell-fate conversion | Yuin-Han Jonathan LOH |
| 11:50-12:00 | RNA m6A Modifications in T Cell Differentiation and Inflammation | Huabing Li (Shanghai Jiao Tong University School of Medicine) |
| 12:00-13:10 | Lunch | |
| Short-talks Chair： Yanhui Xu | ||
| 13:10-13:20 | A new layer of rRNA regulation by small interference RNAs and the nuclear RNAi pathway | Shouhong Guang (University of Science and Technology of China) |
| 13:20-13:30 | MAnorm2: quantitative comparison of ChIP-seq samples on group level to identify sex-biased histone modification sites | Zhen Shao（AcademiaSinica，Shanghai） |
| 13:30-13:40 | m6A methyltransferase complex regulates hematopoietic stem cell self-renewal in the bone marrow | Bo Zhou（AcademiaSinica，Shanghai） |
| 13:40-13:50 | Function and mechanism of 2OG-oxygenase JMJD6 in breast carcinogenesis | Wen Liu（Xiamen University ） |
| IV.Clinical Epigenetics | ||
| Chair of the first half part : Tapas Kundu(India) | ||
| 13:50-14:10 | Implication of Long Non-coding RNAs in Cancer Biology | Yutaka Kondo (NagoyaUniversity, Japan) |
| 14:10-15:35 | Global transcriptional memory is mediated by H3K4me3-Rpd3L HDAC pathway | TaeSoo Kim |
| 15:35-16:00 | Whole-Genome and Epigenomic Landscapes of Etiologically DistinctSubtypes of Cholangiocarcinoma | Teh Bin Tean (CancerCenter, Singapore), |
| 16:00-16:25 | Functional prediction of causal regulatory variants identifies a novelautism gene | Jung Kyoon Choi (Korea) |
| 16:25-16:50 | Tea Break | |
| Chair of the second half part: Zefeng Wang(Academia Sinica) | ||
| 16:50-17:15 | Histone acetylome-wide association study identifies epigenetic changesand a protective host response mechanism to infection | ShyamPRABHAKAR |
| 17:15-17:25 | Characterization of interaction modes between the BRM bromodomain and inhibitors in the limit of NMR intermediate exchange | Ke Ruan（University of Science and Technology of China） |
| 17:25-17:35 | Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA methyltransferase-1 (DNMT1) | Shijie Chen(Academia Sinica, Shanghai） |
| 17:35-17:45 | Drug discovery of protein-protein interactions by targeting epi-modification sites of untargetable protein | Wenchao Lu( Academia Sinica, Shanghai) |
| 21st, Sept, 2018 | ||
| V.Chemical and biological perspectives of the higher-order chromatin structure | ||
| Chair of the first half part: Young-Joon Kim(Korea) | ||
| 8:30-8:55 | Crosstalk between histone modifications during heterochromatinassembly | Jun-ichi Nakayama(Tokyo，Japan) |
| 8:55-9:20 | Dynamic regulation of higher-order chromatin structures in generegulation | Guohong Li (AdademiaSinica, Beijing) |
| 9:20-9:45 | Reprogramming of chromatin architecture in early mammaliandevelopment | Wei Xie (Tsinghua University) |
| 9:45-10:10 | Combinatorial mechanisms in 3D genome folding and transcriptionregulation | Yijun Ruan (Jackson Lab,USA) |
| 10:10-10:30 | Tea Break | |
| Chair of the second half part: Lingling Chen(Academia Sinica, Shanghai) | ||
| 10:30-10:55 | Systematic Mapping of RNA-Chromatin Interactions In Vivo | Sheng Zhong (UCSD) |
| 10:55-11:05 | Multisite substrate recognition in Asf1-dependent acetylation of histone H3 K56 by Rtt109 | Lin Zhang ( Academia Sinica, Beijing) |
| 11:05-11:15 | 3D Genome of Multiple Myeloma Reveals Spatial Genome Disorganization Associated with Copy Number Variations | Cheng Li (Peking University) |
| 11:15-11:25 | Chromatin remodelling during brain development | Weijun Feng(Fudan University） |
| 11:25-11:35 | ||
| 11:35-11:45 | A novel RNA epigenetic mechanism: m6A RNA-mediated cell damage response | Zhihong Xu（Zhejiang Univerisity） |
| 11:45-13:00 | Lunch | |
| VI. Developmental Epigenetics | ||
| Chair of the first half part: Guoliang Xu(Academia Sinica, Shanghai) | ||
| 13:00-13:25 | Epigenetic programming by maternal behavior | Moshe Szyf（Canada， McGill University ） |
| 13:25-13:50 | Single-cell multi-omics sequencing of mouse early embryos andembryonic stem cells | Fuchou Tang (PekingUniversity) |
| 13:50-14:00 | Chromatin accessibility landscape in human early embryos and its association with evolution | Lei Gao（Academia Sinica, Beijing） |
| 14:00-14:10 | Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding rnas | Yunfang Zhang（The Third Military Medical University） |
| 14:10-14:20 | lncrna-mir100hg derived mir-100 and mir-125b mediate cetuximab resistance via wnt/β-catenin signaling in colorectal cancer | Yuanyuan Lu（The Fourth Military Medical University） |
| 14:20-14:30 | Stella safeguards the oocyte methylome by preventing excessive de novo methylation mediated by dnmt1 | Zhuqiang Zhang（Academia Sinica） |
| 14:30-14:50 | Tea Break | |
| Chair of the second half part: Xiangdong Fu(UCSD) | ||
| 14:50-15:00 | Spatio-temporal dynamics of chromatin in developmental hematopoietic cells initiating the oncogenic alterations | Dengli Hong（Shanghai Jiao Tong University School of Medicine） |
| 15:00-15:25 | Crosstalk of n-a-acetyltransferase and dna methylation indevelopment and disease | Li-Jung Juan (AdademiaSinica,Taipei) |
| 15:25-15:50 | Small molecule-induced cell fate reprogramming | Hongkui Deng (Peking University) |
| 15:50-16:00 | Closing | |
欲实时把握表观遗传学理论、技术和应用的最新进展，请参加第四届发育和疾病的表观遗传学上海国际研讨会（2018 年 9 月 18-21 日，上海）
时间: 2018-09-18 至 2018-09-21
地点：复旦大学附属中山医院 18 号楼 3 楼福庆厅（上海市徐汇区枫林路 179 号）
联系人： 张老师
邮箱：chris.zhang@bio360.net
电话：021-59555696 / 18516613552（微信同号）
