研究员,博士生导师,复旦大学附属上海市公共卫生临床中心科研院长
地址:上海市金山区漕廊公路2901号科研楼 308室
电话:021-37990333转7335
邮箱:xujianqing@shphc.org.cn
实验室主页:http://www.hiv.fudan.edu.cn
艾滋病免疫抑制疗法和根治策略研究;获批经费2185万元(子课题组组长)
1.Zhang W, Xu L, Park HB, Hwang J, Kwak M, Lee PCW, Liang G, Zhang X, Xu J, Jin JO. Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy. Nat Commun. 2020; 11:1187. doi: 10.1038/s41467-020-15030-4.
2.Qiu T, Yang Y, Qiu J, Huang Y, Xu T, Xiao H, Wu D, Zhang Q, Zhou C, Zhang X, Tang K, Xu J*, Cao Z*. CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens. Nature Communication, 2018, 9(1): 1772
3.Wang Z, Zhu L, Nguyen T, Wan Y, Sant S, Quiñones-Parra S, Crawford J, Eltahla A, Rizzetto S, Bull R, Qiu C, Koutsakos M, Clemens B, Loh L, Chen T, Liu L, Cao P, Ren Y, Kedzierski L, Kotsimbos T, McCaw J, Gruta N, Turner S, Cheng A, Luciani F, Zhang X, Doherty P, Thomas P, Xu J* and Kedzierska K* Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease. Nature Communication, 2018, 9: 824
4.Jian Chen, Yi-feng Yang, Yu Yang, Peng Zou, Jun Chen, Yongquan He, Sai-lan Shui, Yan-ru Cui, Ru Bai, Ya-jun Liang, Yunwen Hu, Biao Jiang, Lu Lu, Xiaoyan Zhang*, Jia Liu*, Xu J*. AXL Promotes Zika Virus Infection in Astrocytes by Antagonizing Type I Interferon Signaling. Nature Microbiology, 2018, 3(3): 302-309. doi: 10.1038/s41564-017-0092-4.
5.Zhao C*, Xu J*. Toward universal influenza virus vaccines: from natural infection to vaccination strategy. Curr Opin Immunol. 2018,53:1-6.
6.Ran He, Shiyue Hou, Cheng Liu, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Xu J, Hai Qi*, Yuzhang Wu* and Lilin Ye*. Follicular CXCR5-expressing CD8 T cells curtail chronic viral infection. Nature, 2016, 537 (7620):412-428. doi: 10.1038/nature19317.
7.Liyen Loh, Zhongfang Wang, Sneha Sant, Marios Koutsakos, Sinthujan Jegaskanda, Alexandra J Corbett, Ligong Liu, David P Fairlie, Jane Crowe, Jamie Rossjohn, Xu J, Peter C Doherty, James McCluskey, Katherine Kedzierska. Human mucosal-associated invariant T cells contribute to anti-viral influenza immunity via IL-18 dependent activation. PNAS, 2016; 113(36):10133-8. doi: 10.1073/pnas.1610750113.
8.Wang Z, Wan Y, Qiu C, Quiñones-Parra S, Zhu Z, Loh L, Tian D, Ren Y, Hu Y, Zhang X, Thomas PG, Inouye M, Doherty PC, Kedzierska K*, Xu J*. Rapid recovery from severe H7N9 disease requires a diversity of response mechanisms dominated by CD8+ T cells. Nat. Commun. 2015, 6: 6833. doi: 10.1038/ncomms7833.
9.Zhe Bao Wu, Lin Cai, Chao Qiu, An Li Zhang, Shao Jian Lin, Yu Yao, Xu J*, and liangfu zhou*. CTL responses to HSP47 associated with the prolonged survival of glioblastomas patients. Neurology, 2014, 82(14):1261-5. (2015 IF=8.28; 5-Year IF=8.35)
10.Wang Z, Zhang A, Wan Y, Liu X, Qiu C, Xi X, Ren Y, Wang J, Dong Y, Bao M, Li L, Zhou M, Yuan S, Sun J, Zhu Z, Chen L, Li Q, Zhang Z, Zhang X, Lu S, Doherty PC, Kedzierska K, Xu J*. Early hypercytokinemia is associated with IFITM3 dysfunction and predictive of fatal H7N9 infection. PNAS, 2014, 111:769-74.
11.Qiu C, Huang Y, Wang Q, Tian D, Zhang W, Hu Y, Yuan Z, Zhang X, Xu J*. Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine. Clinical Infectious Diseases, 2012. 54: 17-24. (2015 IF=8.88, 5-Year IF=9.2)
12.Yong Qiao, Yang Huang, Chao Qiu, Xinye Yue, Liandong Deng, Yanmin Wan, Jinfeng Xing, Congyou Zhang, Songhua Yuan, Anjie Dong, Xu J*. The Use of PEGylated Poly [2-(N, N-dimethylamino) ethyl methacrylate] as A Mucosal DNA Delivery Vector and the Activation of Innate Immunity and Improvement of HIV-1-specific Immune Responses. Biomaterials, 31 (2010): 115–123. (2015 IF=8.55, 5-Year IF=9.3)
13.Liu, S., C. Qiu, R. Miao, J. Zhou, W. Fu, L. Zhu, L. Zhang, Xu J, M. Fu, and T. Wang. 2013. MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells. PNAS 2013;110(47):19083-8. doi: 10.1073/pnas.1316208110.
14.Lori F, Lewis M, Xu J, Varga G, Zinn D, Crabbs C, Wagner W, Greenhouse J, Silvera P, Yalley-Ogunro J, Tinelli C & Lisziewicz J. Control of SIV rebound through structured treatment interruptions during early infection. Science, 290: 1591~93, 2000.