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  • 沈宏杰

    博士,研究员,博士生导师
    地址:东安路131号,上海 200032
    电话:021-54237821
    邮箱:hongjieshen@fudan.edu.cn
    国家重点研发计划青年项目首席科学

工作经历
研究员,复旦大学,生物医学研究院(2021.01-至今)
青年研究员,复旦大学,生物医学研究院(2018.08-2020.12)
博士后,复旦大学,生物医学研究院(2015.12-2018.07)
教育经历
博士,复旦大学,生物医学研究院(2009.09-2015.07)
学士,四川大学,生物技术基地班(2005.09-2009.07)
所获人才项目
国家自然科学基金优秀青年基金,2021
上海市科委青年启明星,2019
所获奖项

研究方向
1.新型表观遗传修饰及调控因子的筛选鉴定;2. 跨物种表观遗传修饰的功能探索。
招生专业
生物化学与分子生物学
代表论文

1.Daixuan Zhang#; Li Dong#; Ying Cai; Peng Zhao; Qingqing Cai; Jian Zhang; Yajun Hu; Mandi Mu; Siyi Cheng; Jin Wang; Min Zeng; Chenxi He; Lei Zhang; Hui Yang; Fei Xavier Chen; Li Tan; Feizhen Wu; Yujiang Geno Shi; Wenqi Xu*, Hongjie Shen*, SPT6 Regulates H3K14Ac Deposition in Mouse Embryonic Stem Cells, Cell Reports, 2025 May 30;44(6):115757.

2.Wenqi Xu, Hongjie Shen*, m6A regulates heterochromatin in mammalian embryonic stem cells. Current Opinion in Genetics & Development. 2024 Jun;86:102196.

3.Mandi Mu, Xinze Li, Li Dong, Jin Wang, Qingqing Cai, Yajun Hu, Duanduan Wang, Peng Zhao, Lei Zhang, Daixuan Zhang, Siyi Cheng, Li Tan, Feizhen Wu, Yujiang Geno Shi, Wenqi Xu*, Yang Shi*, and Hongjie Shen*, METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells, Cell Reports, 2023 Jun 27;42(6):112650.

4.Wenqi Xu#, Chenxi He#, Emily G. Kaye, Jiahui Li, Mandi Mu, Geoffrey M. Nelson, Li Dong, Jiahua Wang, Feizhen Wu, Yujiang Geno Shi, Karen Adelman*, Fei Lan*, Yang Shi* and Hongjie Shen*, Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis, Molecular Cell, 2022 Mar 17;82(6):1156-1168.e7.

5.Wenqi Xu, Hongjie Shen*, When RNA methylation meets DNA methylation. Nature Genetics. 2022 Sep;54(9):1261-1262.

6.Wenqi Xu, Jiahui Li, Chenxi He, Jing Wen, Honghui Ma, Bowen Rong, Jianbo Diao, Liyong Wang, Jiahua Wang, Feizhen Wu, Li Tan, Yujiang Geno Shi, Yang Shi*, Hongjie Shen*, METTL3 regulates heterochromatin in mouse embryonic stem cells, Nature. 2021 Mar;591(7849):317-321.

7.Jiahua Wang#, Liyong Wang#, Jianbo Diao, Yujiang Geno Shi, Yang Shi*, Honghui Ma*, Hongjie Shen*, Binding to m6A RNA promotes YTHDF2-mediated phase separation. Protein Cell. 2020 Apr;11(4):304-307.

8.Wenqi Xu#, Jiahui Li#, Bowen Rong#, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen*, Feizhen Wu*, Fei Lan*; DNMT3A reads and connects histone H3K36me2 to DNA methylation. Protein Cell. 2020 Feb;11(2):150-154. 

9.Hongjie Shen#, Wenqi Xu#, Rui Guo, Bowen Rong, Lei Gu, Zhentian Wang, Chenxi He, Lijuan Zheng, Xin Hu, Zhen Hu, Zhi-Ming Shao, Pengyuan Yang, Feizhen Wu, Yujiang Geno Shi, Yang Shi*, Fei Lan*, Suppression of enhancer overactivation by a RACK7-Histone demethylase complex, Cell, 2016, 165(2):331-342.

10.Hongjie Shen#, Wenqi Xu#, Fei Lan*. Histone lysine demethylases in mammalian embryonic development. Exp Mol Med. 2017 Apr 28;49(4):e325.


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