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  • 沈宏杰

    博士,研究员,博士生导师
    地址:东安路131号,上海 200032
    电话:021-54237821
    邮箱:hongjieshen@fudan.edu.cn
    国家重点研发计划青年项目首席科学

工作经历
研究员,复旦大学,生物医学研究院(2021.01-至今)
青年研究员,复旦大学,生物医学研究院(2018.08-2020.12)
博士后,复旦大学,生物医学研究院,(2015.12-2018.07)
教育经历
博士,复旦大学,生物医学研究院(2009.09-2015.07)
学士,四川大学,生物技术基地班(2005.09-2009.07)
所获人才项目

国家自然科学基金优秀青年基金,2021
上海市科委青年启明星,2019

所获奖项

研究方向
1.RNA及RNA结合蛋白的染色质调控功能;2. 新型表观遗传修饰及调控因子的筛选鉴定。
代表论文

1) Wenqi Xu, Jiahui Li, Chenxi He, Jing Wen, Honghui Ma, Bowen Rong, Jianbo Diao, Liyong Wang, Jiahua Wang, Feizhen Wu, Li Tan, Yujiang Geno Shi, Yang Shi*, Hongjie Shen*, METTL3 regulates heterochromatin in mouse embryonic stem cells, Nature. 2021 Mar;591(7849):317-321.

2) Wenqi Xu#, Chenxi He#, Emily G. Kaye, Jiahui Li, Mandi Mu, Geoffrey M. Nelson, Li Dong, Jiahua Wang, Feizhen Wu, Yujiang Geno Shi, Karen Adelman*, Fei Lan*, Yang Shi* and Hongjie Shen*, Dynamic Control of Chromatin-associated m6A Methylation Regulates Nascent RNA Synthesis, Mol Cell, 2022 https://doi.org/10.1016/j.molcel.2022.02.006.

3) Hongjie Shen#, Wenqi Xu#, Rui Guo, Bowen Rong, Lei Gu, Zhentian Wang, Chenxi He, Lijuan Zheng, Xin Hu, Zhen Hu, Zhi-Ming Shao, Pengyuan Yang, Feizhen Wu, Yujiang Geno Shi, Yang Shi*, Fei Lan*, Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex, Cell, 2016, 165(2):331-342.

4) Wenqi Xu#, Jiahui Li#, Bowen Rong#, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen*, Feizhen Wu*, Fei Lan*; DNMT3A reads and connects histone H3K36me2 to DNA methylation. Protein Cell. 2020 Feb;11(2):150-154. 

5) Jiahua Wang#, Liyong Wang#, Jianbo Diao, Yujiang Geno Shi, Yang Shi*, Honghui Ma*, Hongjie Shen*, Binding to m6A RNA promotes YTHDF2-mediated phase separation. Protein Cell. 2020 Apr;11(4):304-307.

6) Hongjie Shen#, Wenqi Xu#, Fei Lan*. Histone lysine demethylases in mammalian embryonic development. Exp Mol Med. 2017 Apr 28;49(4):e325.

7) Fangfang Jiao#, Ze Li#, Chen He, Wenqi Xu, Gensheng Yang, Tingting Liu, Hongjie Shen, Jiajun Cai, Jamie N Anastas, Ying Mao, Yongchun Yu, Fei Lan, Yujiang Geno Shi, Chris Jones, Yanhui Xu, Suzanne J Baker*, Yang Shi*, Rui Guo*. RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma. Sci Adv. 2020 Jul 17;6(29):eaba2113.

8) Xi Jin, Xiao-En Xu, Yi-Zhou Jiang, Yi-Rong Liu, Wei Sun, Ya-Jie Guo, Yi-Xing Ren, Wen-Jia Zuo, Xin Hu, Sheng-Lin Huang, Hong-Jie Shen, Fei Lan, Yun-Fei He, Guo-Hong Hu, Gen-Hong Di, Xiang-Huo He, Da-Qiang Li, Suling Liu, Ke-Da Yu, Zhi-Ming Shao*. The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation. Sci Adv. 2019 Mar 6;5(3):eaat9820.

9) Hao Cheng, Hongwen Xuan, Christopher D Green, Yixing Han, Na Sun, Hongjie Shen, Joseph McDermott, David A Bennett, Fei Lan, Jing-Dong J Han*. Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7611-7616.

10) Yi-Zi Zheng, Meng-Zhu Xue, Hong-Jie Shen, Xiao-Guang Li, Ding Ma, Yue Gong, Yi-Rong Liu, Feng Qiao, Hong-Yan Xie, Bi Lian, Wei-Li Sun, Hai-Yun Zhao, Ling Yao, Wen-Jia Zuo, Da-Qiang Li, Peng Wang, Xin Hu*, Zhi-Ming Shao*. PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression. Cancer Res. 2018 Jun 15;78(12):3190-3206.

11) Jing Wen#, Ruitu Lv#, Honghui Ma#, Hongjie Shen, Chenxi He, Jiahua Wang, Fangfang Jiao, Hang Liu, Pengyuan Yang, Li Tan, Fei Lan, Yujiang Geno Shi, Chuan He*, Yang Shi*, Jianbo Diao*, Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal. Mol Cell. 2018 Mar 15;69(6):1028-1038.

12) Na Li, Yuanyuan Li, Jie Lv, Xiangdong Zheng, Hong Wen, Hongjie Shen, Guangjing Zhu, Tsai-Yu Chen, Shilpa S Dhar, Pu-Yeh Kan, Zhibin Wang, Ramin Shiekhattar, Xiaobing Shi, Fei Lan, Kaifu Chen, Wei Li, Haitao Li, Min Gyu Lee. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Mol Cell. 2016 Aug 4;63(3):470-84.



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