博士，青年研究员
地址：上海市医学院路138号，上海 200032
电话：
传真：
邮箱：luluhu@fudan.edu.cn
Weizhi He*, Xiaotong Yin*, Chu Xu*, Xiangyue Liu, Yue Huang, Caiguang Yang, Yanhui Xu, and Lulu Hu#. Ascorbic Acid Reprograms Epigenome and Epitranscriptome by Reducing Fe (III) in the Catalytic Cycle of Dioxygenases. ACS Chem Biol. 2023 Dec 15.
Ruiqi Ge, Chang Ye, Yong Peng, Qing Dai, Yutao Zhao, Shun Liu, Pingluan Wang, Lulu Hu#, Chuan He# m6A-SAC-seq for quantitative whole transcriptome m6A profiling. Nat Protoc. 2023 Feb;18(2):626-657. doi: 10.1038/s41596-022-00765-9. (#represents corresponding author.)
Hu L*#, Liu S*, Peng Y*, Ge R*, Su R*, Senevirathne C, Harada BT, Dai Q, Wei J, Zhang L, Hao Z, Luo L, Wang H, Wang Y, Luo M, Chen M#, Chen J#, He C#. m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome. Nat Biotechnol. 2022 Aug;40(8):1210-1219. doi: 10.1038/s41587-022-01243-z. Epub 2022 Mar 14. (*represents equal contribution, #represents corresponding author.)
Yong Peng, Hanzhe Meng, Ruiqi Ge, Shun Liu, Mengjie Chen, Chuan He, Lulu Hu#. Detection of m6A RNA modifications at single-nucleotide resolution using m6A-selective allyl chemical labeling and sequencing. STAR Protoc. 2022 Dec 16;3(4):101677. doi: 10.1016/j.xpro.2022.101677.
Lulu Hu#. Quantitative and single nucleotide RNA m6 A detection technology boosts clinical research based on tissue and cell free RNA modification. Clin Transl Med. 2022 Oct;12(10): e1082. doi: 10.1002/ctm2.1082.
Hu L*, Liu Y*, Han S*, Yang L*, Cui X, Gao Y, Dai Q, Lu X, Kou X, Zhao Y, Sheng W, Gao S, He X, He C. Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites. J Am Chem Soc. 2019 Jun 5;141(22):8694-8697. doi: 10.1021/jacs.9b02512. Epub 2019 May 23.
Zhang LS, Liu C, Ma H, Dai Q, Sun HL, Luo G, Zhang Z, Zhang L, Hu L, Dong X, He C. Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA. Mol Cell. 2019 Jun 20;74(6):1304-1316.e8. doi: 10.1016/j.molcel.2019.03.036. Epub 2019 Apr 25.
Ji L, Jordan WT, Shi X, Hu L, He C, Schmitz RJ. TET-mediated epimutagenesis of the Arabidopsis thaliana methylome. Nat Commun. 2018 Mar 1;9(1):895. doi: 10.1038/s41467-018-03289-7.
Wang W, Xu L, Hu L, Chong J, He C, Wang D. Epigenetic DNA Modification N6-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing. J Am Chem Soc. 2017 Oct 18;139(41):14436-14442. doi: 10.1021/jacs.7b06381. Epub 2017 Oct 3.
Lu J*, Hu L*, Cheng J, Fang D, Wang C, Yu K, Jiang H, Cui Q, Xu Y, Luo C. A computational investigation on the substrate preference of ten-eleven-translocation 2 (TET2). Phys Chem Chem Phys. 2016 Feb 14;18(6):4728-38. doi: 10.1039/c5cp07266b. (*represents equal contribution).
Hu L, He C. Detecting hepatocellular carcinoma in blood. Cell Res. 2015 Dec;25(12):1279-80. doi: 10.1038/cr.2015.136. Epub 2015 Nov 24.
Hu L*, Lu J*, Cheng J*, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Structural insight into substrate preference for TET-mediated oxidation. Nature2015 Nov 5;527(7576):118-22. (*represents equal contribution).
Hu L*, Li Z*, Cheng J*, Rao Q, Gong W, Liu M, Shi YG, Zhu J, Wang P, Xu Y. Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation. Cell2013 Dec 19;155(7):1545-55 (*represents equal contribution).
Hu L*, Li Z*, Wang P, Lin Y, Xu Y. Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2. Cell Res. 2011 Sep;21(9):1374-8 (*represents equal contribution).
Rajakumara E*, Wang Z*, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y. PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression. Mol. Cell2011 Jul 22;43(2):275-84 (*represents equal contribution).
Yang Y*, Hu L*, Wang P*, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, Xu Y.Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug;20(8):886-98 (*represents equal contribution).
Patents:
一种含5hmC 单细胞的检测方法。胡璐璐，蒋晓
一种亚细胞结构中RNA 的检测方法。胡璐璐，蒋晓
•Methods for detecting cytosine modification.
•m6A-SAC-seq for quantitative RNA m6A sequencing.
