鲁白

师资队伍

特聘教授

鲁白

发表时间：2026-03-11　　|　　阅读次数：19523次　　|　　字体大小 [ 小中大 ]

鲁白
博士，复旦大学特聘教授，博士生导师，上海尚思自然科学研究院院长
邮箱：bailu@fudan.edu.cn

工作经历

特聘教授，复旦大学生物医学研究院（2024-今）
教授，清华大学药学院（2016-2024）
教授、医学院常务副院长，清华大学医学院（2013-2015）
中国研发部副总裁，葛兰素史克（2009-2013）
基因、认知与精神研究部（GCAP）副主任， NIH精神健康研究所（NIMH）（2003-2009）
神经发育研究室主任，美国国立卫生研究院（NIH）儿童发育研究所（1996 -2009）
助理教授，美国罗氏分子生物学研究所及哥伦比亚大学生物系（1993-1996）
博士后（导师：诺贝尔奖得主 Paul Greengard），美国洛克菲勒大学（1990 -1993）

教育经历

博士（导师：著名神经生物学家、时任美国神经科学会主席 Ira Black 教授），美国康奈尔大学医学院，1990
硕士，上海第一医科大学，1985
学士，华东师范大学本科，1982

所获奖项

爱思唯尔“中国高被引学者”，2016-2025
汤森路透集团神经科学和行为学“高被引科学家”，2014
Ray Wu 奖，2006
NIH院长奖，2006
APAO奖，2003
Mathilde Solowey奖，2003
Staff Recognition Award (NICHD)，2001-2003
白玉兰杰出科技人才奖，1998
殷志浩大陆杰出青年科学家奖，1989

研究方向

1996 年，鲁白教授发现 BDNF 能够增强海马神经元的突触传递和长时程增强（LTP），从而促进学习和记忆。该成果与国际同行共同开创了神经营养因子调控突触可塑性的新领域。2003 年，他与Weinberger教授发现 BDNF 基因上的单核苷酸多态性（Val66Met）影响 BDNF 的分泌效率，并导致人类情景记忆能力差异，相关研究发表于Cell，并被Science评为2003 年度世界十大科学突破第二名。他提出 BDNF 作用的 “阴阳机制” 假说：成熟 BDNF（mBDNF）促进神经元存活与突触生长（“阳”），其前体 proBDNF 则通过 p75 受体介导细胞凋亡与突触修剪（“阴”）。基于该机制，团队研发 TrkB 受体激动型抗体，可特异性激活神经保护通路，在阿尔茨海默病、肌萎缩侧索硬化症（ALS）和脑卒中等动物模型中展现出良好治疗效果。2024 年，其团队成功构建新型阿尔茨海默病 APPNL-G-F 大鼠模型，精准模拟人类 AD 的 Aβ 沉积、tau 病变、神经元死亡与脑萎缩等病理特征，弥补了传统转基因小鼠模型的不足，为 AD 机制研究与药物研发提供了更理想的工具。
鲁白教授实验室综合运用分子与细胞生物学、电生理、光遗传学、行为学、活体显微成像、遗传学等手段，研究脑认知功能的神经环路、突触可塑性、神经与精神疾病及神经修复的分子基础，并开展神经系统疾病创新药物研发。主要研究方向包括：（1）神经营养因子在神经退行性疾病中的基础与转化研究；（2）BDNF 相关神经系统疾病药物研发；（3）BDNF 与突触可塑性调控高级脑功能研究；（4）前额皮层认知功能与神经环路研究；（5）AD大鼠模型、脑类器官等疾病模型研究；（6）阿尔茨海默病等神经疾病新风险基因鉴定与致病机制研究。

招生专业

生物化学与分子生物学

代表论文

Selected publications (out of 132 published)

1.H. Liu, F. Mei, R. Ye, S. Wang, Y. Ding, X. Han, Y. Zhi, K. Pang, B. Lu (2024). APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APP^NL-G-F cerebral organoid model of Alzheimer’s disease. Cell Res. 34(6):451-454. doi: 10.1038/s41422-024-00957-w. Important paper. Reported an organoid model closely resembling human AD, and demonstrated the powerful effect of APOE3ch on AD pathology.

2.F. Mei, C. Zhao, S. Li, Z. Xue, Y. Zhao, Y. Xu, R. Ye, H. You, P. Yu, X. Han, G. Carr, D. R. Weinberger, F. Yang, B. Lu (2024). Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory. Nature Communication. 15(1):7342. doi: 10.1038/s41467-024-51707-w.

3.F. Yang, H. You, T. Mizuia, (co-first author), K. Kiyosuea, K. Takao, T. Miyakawa, X. Li, T. Bai, K. Xia, L. Zhang, D. Pang, Y. Xu, C. Zhu, M. Kojima, B. Lu (2024). Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo. Mol. Psychiatry.29:3462–3474. doi: 10.1038/s41380-024-02595-5.

4.F. W. Pun, B. H. M Liu, X. Long, J. D. Rothstein, M. E. Cudkowicz, I. V. Ozerov, H. W. Leung, G. H. D. Leung, A. Shneyderman, J. Wang, F. Ren, A. Aliper, X. Guan, B. Lu (co-corresponding author), A. Zhavoronkov (2022). Identification of therapeutic targets and drug repurposing candidates for amyotrophic lateral sclerosis using PandaOmics^TM – an AI-enabled biological target discovery platform. Frontier in Aging Neuroscie. 14:914017.

5.X. Qin, Y. Zhao, Y. Xu, T. Zhang, C. Yin. J. Qiao, W. Guo, B. Lu (2022). TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice. Nature Communication. 13(1):914.

6.K. Pang, R. Jiang, W. Zhang, Z. Yang, L. Li, M. Shimozawa, S. Tambaro, J. Mayer, B. Zhang, M. Li, J. Wang, H. Liu, A. Yang, X. Chen, J. Liu, B. Winblad, H. Han, T. Jiang, W. Wang, P. Nilsson, W. Guo, B. Lu (2021). An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Research. 32(2):157–175. Important paper. First animal model for Alzheimer’s disease with both full spectrum of AD pathology (Ab and tau) and cell death (apoptosis and necroptosis).

7.S. Wang, H. Yao, Y. Xu, R. Hao, W. Zhang, H. Liu, Y. Huang, W. Guo, B. Lu (2020). Therapeutic potential of a TrkB agonist antibody for Alzheimer’s disease. Theranostics. 10:6854-6874.

8.W. Guo, Y. Chen, K. Pang, H. Li, S. Wang, H. Yao1, Y. Xu, H. Liu, V. Lopes-Rodrigues, W. Wu, B. Lu (2019). TrkB agonist antibodies with unique properties superior to BDNF. Neurobiology of Diseases. 132:104590. Important paper. Developed a novel TrkB agonist antibody with unique properties superior to BDNF.

9.F. Han, X. M. Guan, W. Guo, B. Lu (2019). Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury. Neurobiology of Diseases. 127:570-581.

10.K. Sakata K. Martinowich, N. H. Woo, D. V. Jimenez, R. Schlosser, Y. Ji, L. Shen, B. Lu (2013). Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance. Proc. Natl. Acad. Sci. USA. 110:15103-15118. Important paper. Revealed that activity-dependent BDNF expression is critical for behavioral flexibility.

11.H. –S. Je, S. Portruli, F. Yang, H. –S. Je, S. Portruli, Y. Ji, G. Nagappan, B. Hempstead, Y. Son, and B. Lu(2012).Role of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proc. Natl. Acad. Sci. USA. 109:15924-15929.Important paper. Revealed a molecular mechanism underlying activity-dependent synaptic competition, a central issue in developmental neurobiology.

12.N. H. Woo, H.K. Teng, C. –J. Siao, C. Chiaruttini, P. T. Pang, T. A. Milner, B. L. Hempstead, and B. Lu (2005). Activation of p75 NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience.8: 1069-1077. Highlights by Morgan Sheng, Nature. 442, 4.Important paper. Discovered the role of ProBDNF p75^NTR signaling in synaptic plasticity, formed the basis for “Yin and Yang Hypothesis of Neurotrophin”.

13.P. T. Pang, H. K. Teng, N. Woo, E. Zaitsev, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead, B. Lu (2004). Cleavage of ProBDNF by the tPA/plasmin is essential for long-term hippocampal plasticity. Science. 306:487-491. Important paper. Discovered the extracellular protease cleavage of proBDNF in the brain, and the role proBDNF to mature BDNF conversion in long-term synaptic plasticity.

14.M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, E. Zaistev, A. Bertolino, B. Gold, D. Goldman, M. Dean, B. Lu (co-corresponding author) and D. R. Weinberger (2003). A single nucleotide polymorphism in BDNF gene affects regulated secretion of BDNF and human memory and hippocampal function. Cell. 112:257-269. Highly cited paper. Provided the first link between a human genetic polymorphism and cellular and cognitive function. Selected byScience as No. 2 in “10 Breakthrough of the Year”.

15.Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson, B. Lu (1996). Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381:706-709. Highly cited paper. Viewed as pioneering study of neurotrophin regulation of synaptic plasticity.

16.T. Wang, K. Xie, and B. Lu (1995). Neurotrophins promote maturation of developing neuromuscular synapses. J. Neurosci. 15:4796-4805. Important paper. First report of long-term regulation of synapses by neurotrophins.

17.H. G. Kim, T. Wang, P. Olafsson, and B. Lu (1994). Neurotrophin-3 potentiates neuronal excitability and inhibits g-aminobutyratergic synaptic transmission in cortical neurons. Proc. Natl. Acad. Sci. USA. 91:12341-12345. Important paper. First demonstration of acute effects of a neurotrophin on CNS neurons and synapses.

Selected reviews (out of 40 published)

1.L. Tan, K. Song, B. Lu (2026). China’s innovation in translational medicine: rethinking early-stage clinical development. Nature Biotechnologies.https://doi.org/10.1038/s41587-025-02998-x

2.B. Lu, G. Nagappan, X. Guan, and P. Wren (2013). BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nature Review Neuroscience. 14:401-416. Proposed a new strategy, ‘BDNF-based neural repair’, for neurodegenerative diseases.

3.K. Martinowich, H. Manji, B. Lu (2007). New insights into BDNF function in depression and anxiety. Nature Neuroscience. 10:1089-1093. Provided new perspectives to mechanisms underlying psychiatric disorders based on advances in BDNF cell biology.

4.B. Lu, N. H. Woo, and P. T. Pang (2005). Yin and Yang of neurotrophin regulation. Nature Review Neuroscience. 8:603-614. Proposed “Yin-Yang hypothesis”: pro to mature neurotrophins elicit opposing roles through distinct receptors, and therefore proteolytic cleavage of proneurotrophis may control the direction of neurotrophin actions.