双聘课题组长
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  • 邹云增

    上海市心血管病研究所副所长,复旦大学附属中山医院临床研究院副院长,心实验室主任, 博士生导师

    地址:东安路 131号,明道楼 603室,上海 200032 

    电话:021-54237969 (办公室)

    传真:021-54237969

    邮箱:zou.yunzeng@zs-hospital.sh.cn


工作经历
教授 复旦大学,附属中山医院(2004.9-今)
教授 复旦大学, 附属中山医院/生物医学研究院 (双聘)(2005,6-至今)
研究员 东京大学医学部心内科和千叶大学医学部心内科(2000.4-2004.8)
博士后 东京大学医学部心内科 (1993.4-1997.3)
主治医师 青岛医学院附属医院心内科 (1984.9-1993.3)
教育经历
博士 日本东京大学医学部心内科 (1993.4-1997.3)
学士 北京医学院医学系(1979.9-1984.8)
所获人才项目
长江学者特聘教授 教育部 2005
国家杰出青年科学基金 国家自然科学基金 2006
上海市优秀学术带头人 上海市科委 2005
所获奖项
上海市侨界杰出人物 上海市政府 2015
华夏医学三等奖 健康促进会 2014
中华医学会科技三等奖 中华医学会 2014
上海市科技进步一等奖 上海科协 2014
教育部科技进步二等奖 教育部 2014
上海市科技精英 上海市政府 2013
上海市医学科技二等奖 上海医学会 2012
研究方向
主要从事心血管系统内科学的研究,主要是高血压性心肌肥厚和心衰的发病机理及血管紧张素的作用研究,缺血性心脏病的基因和细胞治疗的研究。在国外杂志包括Nat Cell Biol, Nature, Nat Med, Circulation, Circ Res, J Biol Chem, Hypertension等杂志上发表了100余篇SCI收录学术论文,中文核心期刊论文50余篇。美国Scopus数据中心收录论文74,被引用3098次, H指数:32(2009年)。
代表论文

1: Li Y, Zhang X, Li L, Wang X, Chen Z, Wang X, Wang Y, Kang L, Ye Y, Jia J, Zhang G, Yang C, Yuan J, Zhou J, Ge J, Gong H, Zou Y. Mechanical stresses induce paracrine β-2 microglobulin from cardiomyocytes to activate cardiac fibroblaststhrough epidermal growth factor receptor. Clin Sci (Lond). 2018 Aug 30;132(16):1855-1874.

 

2: Yuan L, Qiu L, Ye Y, Wu J, Wang S, Wang X, Zhou N, Zou Y. Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway. J Cell Mol Med. 2018 Sep;22(9):4292-4303.

 

3: Yuan J, Liu H, Gao W, Zhang L, Ye Y, Yuan L, Ding Z, Wu J, Kang L, Zhang X, Wang X, Zhang G, Gong H, Sun A, Yang X, Chen R, Cui Z, Ge J, Zou Y. MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress. Theranostics. 2018 Apr 3;8(9):2565-2582.

 

4: Wang S, Wu J, You J, Shi H, Xue X, Huang J, Xu L, Jiang G, Yuan L, Gong X, Luo H, Ge J, Cui Z, Zou Y. HSF1 deficiency accelerates the transition from pressure overload-induced cardiac hypertrophy to heart failure through endothelial miR-195a-3p-mediated impairment of cardiac angiogenesis. J Mol Cell Cardiol. 2018 May;118:193-207.

 

5: Chen Z, Li Y, Wang Y, Qian J, Ma H, Wang X, Jiang G, Liu M, An Y, Ma L, Kang L, Jia J, Yang C, Zhang G, Chen Y, Gao W, Fu M, Huang Z, Tang H, Zhu Y, Ge J,Gong H, Zou Y. Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling. Theranostics. 2018 Jan 1;8(3):627-643.

 

6: You J, Wu J, Zhang Q, Ye Y, Wang S, Huang J, Liu H, Wang X, Zhang W, Bu L, Li J, Lin L, Ge J, Zou Y. Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload. Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H552-H562.

 

7: Wo D, Peng J, Ren DN, Qiu L, Chen J, Zhu Y, Yan Y, Yan H, Wu J, Ma E, Zhong TP, Chen Y, Liu Z, Liu S, Ao L, Liu Z, Jiang C, Peng J, Zou Y, Qian Q, Zhu W.Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin. Circulation. 2016 Dec 13;134(24):1991-2007.

 

8: Gao W, Liu H, Yuan J, Wu C, Huang D, Ma Y, Zhu J, Ma L, Guo J, Shi H, Zou Y, Ge J. Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosis via membrane TNF-α mediated NF-κB pathway. J Cell Mol Med. 2016 Dec;20(12):2318-2327.

 

9: Sun Y, Kang L, Li J, Liu H, Wang Y, Wang C, Zou Y. Advanced glycation end products impair the functions of saphenous vein but not thoracic artery smooth muscle cells through RAGE/MAPK signalling pathway in diabetes. J Cell Mol Med. 2016 Oct;20(10):1945-55.

 

10: Wang X, Ye Y, Gong H, Wu J, Yuan J, Wang S, Yin P, Ding Z, Kang L, Jiang Q,Zhang W, Li Y, Ge J, Zou Y. The effects of different angiotensin II type 1 receptor blockers on the regulation of the ACE-AngII-AT1 and ACE2-Ang(1-7)-Masaxes in pressure overload-induced cardiac remodeling in male mice. J Mol Cell Cardiol. 2016 Aug;97:180-90.

 

11: Bai Y, Wang X, Shen L, Jiang K, Ding X, Cappetta D, Zhou J, Ge J, Zou Y. Mechanical Stress Regulates Endothelial Progenitor Cell Angiogenesis Through VEGF Receptor Endocytosis. Int Heart J. 2016 May 25;57(3):356-62.

 

12: Liu H, Gao W, Yuan J, Wu C, Yao K, Zhang L, Ma L, Zhu J, Zou Y, Ge J. Exosomes derived from dendritic cells improve cardiac function via activation of CD4(+) T  lymphocytes after myocardial infarction. J Mol Cell Cardiol. 2016 Feb;91:123-33.

 

13: Lin L, Liu X, Xu J, Weng L, Ren J, Ge J, Zou Y. Mas receptor mediatescardioprotection of angiotensin-(1-7) against Angiotensin II-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress. J Cell Mol Med. 2016 Jan;20(1):48-57.

 

14: Lin L, Liu X, Xu J, Weng L, Ren J, Ge J, Zou Y. High-density lipoprotein inhibits mechanical stress-induced cardiomyocyte autophagy and cardiac hypertrophy through angiotensin II type 1 receptor-mediated PI3K/Akt pathway. J Cell Mol Med. 2015 Aug;19(8):1929-38.

 

15: Huang R, Yao K, Sun A, Qian J, Ge L, Zhang Y, Niu Y, Wang K, Zou Y, Ge J.Timing for intracoronary administration of bone marrow mononuclear cells after acute ST-elevation myocardial infarction: a pilot study. Stem Cell Res Ther. 2015 May 29;6:112.


 16: Gong H, Yan Y, Fang B, Xue Y, Yin P, Li L, Zhang G, Sun X, Chen Z, Ma H, Yang C, Ding Y, Yong Y, Zhu Y, Yang H, Komuro I, Ge J, Zou Y. Knockdown of nucleosome assembly protein 1-like 1 induces mesoderm formation and cardiomyogenesis via notch signaling in murine-induced pluripotent stem cells. Stem Cells. 2014 Jul;32(7):1759-73. 


17: You J, Wu J, Jiang G, Guo J, Wang S, Li L, Ge J, Zou Y. Olmesartan attenuates cardiac remodeling through DLL4tch1 pathway activation in pressure overload mice. J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51.


18: You J, Wu J, Ge J, Zou Y. Comparison between adenosine and isoflurane for assessing the coronary flow reserve in mouse models of left ventricular pressure  and volume overload. Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1199-207. 

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