全聘课题组长
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  • 丰伟军

    博士,青年研究员,博士生导师

    地址:东安路131号

    电话:

    邮箱:fengweijun@fudan.edu.cn

     


工作经历
青年研究员,复旦大学,生物医学研究院 (2018.06-今)
博士后,德国癌症研究中心 (2009.10-2018.05)
教育经历
博士,德国海德堡大学(2005-2009)
硕士,德国海德堡大学(2003-2005)
学士,华中科技大学同济医学院(1996-2001)
所获人才项目

研究方向
染色质调节因子包括染色质重塑因子以及组蛋白和DNA修饰蛋白的功能失调可导致多种神经系统疾病。我的课题组研究的关键问题是染色质调节因子的突变如何特异的导致神经系统发育性疾病。研究目标是阐明导致这些疾病的神经细胞类型以及染色质调节因子在这些细胞里特异的功能。为此我们以转基因小鼠,人大脑类器官和原代神经细胞为工作模型,利用小鼠遗传学,基因编辑和高通量染色质分析等技术手段。所取的研究成果将有助于我们理解相关疾病的致病机理,并为未来的临床介入提供了新的思路。
代表论文

 

1. Feng, W*., Shao, C., Liu HK. (2017) Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease. Frontier Mol. Neuroscience 10:309 

2. Feng, W., Liu HK., Kawauchi D. (2017) CRISPR-engineered genome editing for the next generation neurological disease modeling. Progress in Neuropsychopharmacology & Biological Psychiatry 81:459

3. Feng, W#., Kawauchi, D#., Korkel-Qu, H., Deng, H., Serger, E., Sieber, L., Lieberman, J.A., Jimeno-Gonzalez, S., Lambo, S., Hanna, B.S., et al. (2017). Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Nat Commun 8, 14758.

4. Feng, W., and Liu, H.K. (2017). Revealing the Hidden Powers that Fuel Adult Neurogenesis. Cell Stem Cell 20, 154-156.

5. Feng, W., Liu HK. (2013). Epigenetic regulation of neuronal fate determination: The role of CHD7. Cell Cycle 12 (24): 3707-3708 

6. Feng, W., Khan, M.A., Bellvis, P., Zhu, Z., Bernhardt, O., Herold-Mende, C., and Liu, HK. (2013). The Chromatin Remodeler CHD7 Regulates Adult Neurogenesis via Activation of SoxC Transcription Factors. Cell Stem Cell 13, 62-72. 

7. Xie, W., Ling, T., Zhou, Y., Feng, W., Zhu, Q., Stunnenberg, H.G., Grummt, I., and Tao, W. (2012). The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. Proc Natl Acad Sci U S A, 109, 8161-8166.  

8. Feng, W#., Yonezawa, M#., Ye, J., Jenuwein, T., and Grummt, I. (2010). PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol 17, 445-450.  

9. Yuan, X., Feng, W., Imhof, A., Grummt, I., and Zhou, Y. (2007). Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a. Molecular Cell 27, 585-595. 

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