全聘课题组长
首页  人才队伍  全聘课题组长
  • 卢智刚

    博士,研究员,博士生导师

    地址:东安路 131号,上海 200032 

    邮箱:zhiganglu@fudan.edu.cn


工作经历

研究员,复旦大学生物医学研究院,复旦大学附属上海市第五人民医院兼职教授(2017. 09-今)

助理教授,美国西南医学研究中心,(2012.2-2017.9)

副教授,北京大学深圳研究生院,(2005.10-2012.1)

博士后,北京大学,(2003.10-2005.9)

教育经历
博士北京大学,生命科学学院,(1998.9 – 2003.9)
学士北京大学,生命科学学院,(1994.9 – 1998.7)
所获奖项
1.国家自然科学二等奖,第五完成人,2010
2.教育部自然科学一等奖,第九完成人,2006
研究方向

长期致力于细胞质膜上受体配体相互作用介导的细胞生理和病理行为,主要包括白血病药物靶点和治疗策略、肿瘤免疫治疗、病毒宿主相互作用等方面研究:
 1
分泌组学相互作用平台:针对发生在细胞膜上的各类受体配体相互作用,在全基因组水平筛选和鉴定靶蛋白的未知受体或配体;
 2
白血病药物靶点和治疗策略:开发出针对急性淋系白血病(ALL)和急性髓系白血病(AML)的新靶点和药物,优化造血干细胞HSC体外扩增体系,并推动相关策略向临床进行转化;
 3
肿瘤免疫治疗:寻找鉴定调控肿瘤免疫微环境的关键受体和配体,开发相应治疗抗体和药物;
4
病毒宿主相互作用:利用分泌组学相互作用平台,研究病毒的受体谱系、和其他宿主因子。近期发现了新型冠状病毒的一系列宿主受体,并鉴定出KREMEN1ASGR1ACE2以外的新冠病毒入侵受体。

代表论文

1.Chen, C., Hao, X., Lai, X., Liu, L., Zhu, J., Shao, H., Huang, D., Gu, H., Zhang, T., Yu, Z., Xie, L., Zhang, X., Yang, Y., Xu, J.*, Zhao, Y.*, Lu, Z.*, and Zheng, J.* (2021) Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia. Science Advances 7, eabd6280. (共同通讯作者)

2.Yunqing Gu, Jun Cao, Xinyu Zhang, Hai Gao, Yuyan Wang, Jia Wang, Jinlan Zhang, Guanghui Shen, Xiaoyi Jiang, Jie Yang, Xichen Zheng, Jianqing Xu, Cheng Cheng Zhang, Fei Lan, Di Qu, Yun Zhao, Guoliang Xu, Youhua Xie, Min Luo, Zhigang Lu. Interaction network of SARS-CoV-2 with host receptome through spike protein. BioRixv, https://doi.org/10.1101/2020.09.09.287508. (共同通讯作者)

3.Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek A. H, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You M. J, Homsi J, Unni N, Lewis C, Chen G. Q, Fu Y. X, Liao X. C, An Z, Zheng J, Zhang N, Zhang C. C. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature 2018, 562 (7728), 605-609.

4.Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC. Fasting selectively blocks acute lymphoblastic leukemia development via leptin receptor upregulation. Nature Medicine. 2017. 23(1): 79-90. (共同通讯作者)

5.Nakada, Y., Canseco D. C., Thet S., Abdisalaam S., Asaithamby A., Santos C. X., Shah A., Zhang H., Faber J. E., Kinter M. T., Szweda L. I., Xing C., Deberardinis R., Oz O., Lu Z., Zhang C. C., Kimura W. and Sadek H. A.. Hypoxia induces heart regeneration in adult mice. Nature. 2017. 541(7636): 222-227.

6.Luo M., Wang H., Wang Z., Cai H., Lu Z., Huang G., Chen X., Porembka M., Frankel A, Chen ZJ, Gao J. A STING-activating nanovaccine for cancer immunotherapy. Nat Nanotechnoloty. doi:10.1038/nnano.2017.52. 2017.

7.Kimura, W., Xiao F., Canseco D. C., Muralidhar S., Thet S., Zhang H. M., Abderrahman Y., Chen R., Garcia J. A., Shelton J. M., Richardson J. A., Ashour A. M., Asaithamby A., Liang H., Xing C., Lu Z., Zhang C. C. and Sadek H. A: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature, 2015, 523(7559): 226-230.

8.Kang X, Lu Z, Cui C, Deng M, Fan Y, Dong B, Han X, Xie F, Tyner JW, Coligan JE, Collins RH, Xiao X, You MJ, Zhang C.C: The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development. Nature Cell Biology, 2015; 17(5): 665–677.

9.Deng M*Lu Z*, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao G.F, Jiang Y, Arase H, and Zhang C.C. A motif in LILRB2 critical for Angptl2 binding and activation. Blood. 2014. 924 - 935. (共同一作)

10.Zheng J.*, Lu Z.*, Kocabas F., Bottcher R. T., Costell M., Kang X., Liu X., Deberardinis R. J., Wang Q., Chen G., Sadek H., Zhang C. C. Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood. 2014. 123(7):992-1001. (共同一作

11.Luo M., Ling T., Xie W., Sun H., Zhou Y., Zhu Q., Shen M., Zong L., Lyu G., Zhao Y., Ye T., Gu J., Tao W.#, Lu Z.#, Grummt I#. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells. 2013; 31:1278-1286. (共同通讯作者)

12.Ling T., Xie W., Luo M., Shen M., Zhu Q., Zong L., Zhou T., Gu J., Lu Z. #, Zhang F. #, Tao W#. CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5. Biochem Biophys Res Commun. 2013;437:101-107. (共同通讯作者)

13.Meng S, Luo M, Sun H, Yu X, Shen ML, Zhang QC, Zhou RD, Ju XF, Tao W, Liu D#, Deng HK#, Lu Z#. Identification and characterization of Bmi-1 responding element within the human p16 promoter. Journal of Biological Chemistry. 285, 33219-33229. 2010. (共同通讯作者)

14.Luo M, Lu ZY, Sun H, Yuan KH, Zhang QC, Meng S, Wang FX, Guo HC, Ju XF, Liu YQ, Ye T, Lu Z#, Zhai Z. Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based spacific cleavage activity. Cell Research. 20:211-222. 2010. (通讯作者)

15.Lu Z, Zhang CM, Zhai Z. Nucleoplasmin regulates chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. USA. 102(8): 2778-2783. 2005


Top