长期致力于细胞质膜上受体配体相互作用介导的细胞生理和病理行为，主要包括白血病药物靶点和治疗策略、肿瘤免疫治疗、病毒宿主相互作用等方面研究:
 1）分泌组学相互作用平台：针对发生在细胞膜上的各类受体配体相互作用，在全基因组水平筛选和鉴定靶蛋白的未知受体或配体；
 2）白血病药物靶点和治疗策略：开发出针对急性淋系白血病（ALL）和急性髓系白血病（AML）的新靶点和药物，优化造血干细胞HSC体外扩增体系，并推动相关策略向临床进行转化；
 3）肿瘤免疫治疗：寻找鉴定调控肿瘤免疫微环境的关键受体和配体，开发相应治疗抗体和药物；
4）病毒宿主相互作用：利用分泌组学相互作用平台，研究病毒的受体谱系、和其他宿主因子。近期发现了新型冠状病毒的一系列宿主受体，并鉴定出KREMEN1和ASGR1是ACE2以外的新冠病毒入侵受体。

1.Wang C, Zheng X, Zhang J, Jiang X, Wang J, Li Y, Li X, Shen G, Peng J, Zheng P, Gu Y, Chen J, Lin M, Deng C, Gao H*, Lu Z*, Zhao Y*, Luo M*. CD300ld on neutrophils is required for tumour-driven immune suppression. Nature. 2023 Sep, https://doi.org/10.1038/s41586-023-06511-9. (*: corresponding)

2.Ding H, Li Y, Fang M, Chen J, Liu L, Lu Z*, Hou J*, and Luo M*. Epigenetic activation of the TUSC3 gene as a potential therapy for XMEN disease. Journal of Allergy and Clinical Immunology. 2023 April, https://doi.org/10.1016/j.jaci.2023.04. 003. (*: corresponding)

3.Chen L, Yu Z, Xie L, He X, Mu X, Chen C, Yang W, Tong X, Liu J, Gao Z, Sun S, Xu N, Lu Z*, Zheng J*, Zhang Y*. ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation. Cell Biosci. 2023, 13 (1), 42. (*: corresponding)

4.Jiang X, Wang J, Zheng X, Liu Z, Zhang X, Li Y, Wilhelm J, Sumer BD, Lea L, Lu Z*, Gao J*, Luo M*. Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy. Journal for ImmunoTherapy of Cancer, 2022 May, http://dx.doi.org /10.1136/jitc-2021-003960. (*: corresponding)

5.Gu Y, Cao J, Zhang X, Gao H, Wang Y, Wang J, He J, Jiang X, Zhang J, Shen G, Yang J, Zheng X, Xu J, Lan F, Qu D, Xu G, Zhao Y*, Gao D*, Xie Y*, Luo M*, Lu Z*. Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell Res, 2022 Jan;32(1):24-37. (*: corresponding)

6.Yang J, Shen G, Cao J, Zhang J, Gu Y, Zhang X, Jiang X, Luo M*, Lu Z*. Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2. Biochem Biophys Res Commun. 2022, 617, 42-47. (*: corresponding)

7.Chen C, Hao X, Lai X, Liu L, Zhu J, Shao H, Huang D, Gu H, Zhang T, Yu Z, Xie L, Zhang X, Yang Y, Xu J*, Zhao Y*, Lu Z*, Zheng J* (2021) Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia. Science Advances 2021 Mar 10;7(11):eabd6280. (*: corresponding)

8.Lu Z*, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC*. Fasting selectively blocks acute lymphoblastic leukemia development via leptin receptor upregulation. Nature Medicine. 2017. 23(1): 79-90. (*: corresponding)

9.Luo M, Wang H, Wang Z, Cai H, Lu Z, Huang G, Chen X, Porembka M, Frankel A, Chen ZJ, Gao J. A STING-activating nanovaccine for cancer immunotherapy. Nat Nanotechnoloty. doi:10.1038/nnano.2017.52. 2017.

10.Kang X, Lu Z, Cui C, Deng M, Fan Y, Dong B, Han X, Xie F, Tyner JW, Coligan JE, Collins RH, Xiao X, You MJ, Zhang C.C: The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development. Nature Cell Biology, 2015; 17(5): 665–677.

11.Deng M^#, Lu Z^#, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao G.F, Jiang Y, Arase H, and Zhang C.C. A motif in LILRB2 critical for Angptl2 binding and activation. Blood. 2014. 924 - 935. (Co-first)

12.Zheng J^#, Lu Z^#, Kocabas F, Bottcher RT, Costell M, Kang X, Liu X, Deberardinis RJ, Wang Q, Chen G, Sadek H, Zhang CC. Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood. 2014. 123(7):992-1001. (Co-first)

13.Luo M, Ling T, Xie W, Sun H, Zhou Y, Zhu Q, Shen M, Zong L, Lyu G, Zhao Y, Ye T, Gu J, Tao W*, Lu Z*, Grummt I*. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells. 2013; 31:1278-1286. (*: corresponding)

14.Ling T, Xie W, Luo M, Shen M, Zhu Q, Zong L, Zhou T, Gu J, Lu Z *, Zhang F *, Tao W*. CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5. Biochem Biophys Res Commun. 2013;437:101-107. (*: corresponding)

15.Meng S, Luo M, Sun H, Yu X, Shen ML, Zhang QC, Zhou RD, Ju XF, Tao W, Liu D*, Deng HK*, Lu Z*. Identification and characterization of Bmi-1 responding element within the human p16 promoter. Journal of Biological Chemistry. 285, 33219-33229. 2010. (*: corresponding)

16.Luo M, Lu ZY, Sun H, Yuan KH, Zhang QC, Meng S, Wang FX, Guo HC, Ju XF, Liu YQ, Ye T, Lu Z*, Zhai Z. Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based spacific cleavage activity. Cell Research. 20:211-222. 2010. (*: corresponding)

17.Lu Z, Zhang CM, Zhai Z. Nucleoplasmin regulates chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. USA. 102(8): 2778-2783. 2005