全聘课题组长
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  • 施奇惠

    博士、研究员、博士生导师
    地址:上海市东安路 131号,复旦大学生物医学研究院
    邮箱:qihuishi@fudan.edu.cn


工作经历
研究员,复旦大学,生物医学研究院(2018-今)
教授,上海交通大学,系统生物医学研究院(2011-2018)
博士后,加州理工学院,化学与化工学院(2008-2011)
教育经历
博士,加州大学圣巴巴拉分校,化学(2003-2008)
学士,复旦大学,化学(1999-2003)
所获人才项目
上海市优秀学术带头人(2023-2026)
国家自然科学基金青年基金(2013-2015)、面上项目(2014-2017、2018-2021、2024-2027)
国家重点研发计划“智能传感器”重点专项(2023-2026)
上海市自然科学基金原创探索项目(2020-2023)
国家重点研发计划“精准医学研究”重点专项(2016-2018)
上海市浦江人才计划(2012)
国家级青年人才项目(2012)
所获奖项
中华中医药学会科学技术奖三等奖(2024,3/8)
上海市科技进步一等奖(2023,4/6)
上海医学科技奖一等奖(2023,5/7)
上海中医药科技奖一等奖(2023,4/12)
中华医学科技奖二等奖(2021,3/10)
上海中西医结合科学技术奖二等奖(2020,3/7)
研究方向
课题组主要从事液体活检、单细胞测序与人工智能方面的研究,发展无/低创的基于体液的脱落/循环肿瘤细胞检测、溯源方法用于癌症诊断、预后以及定制个体化治疗。
招生专业
生物化学与分子生物学
代表论文

1.Zhao YC, Qiu RR, Wang Z, Li YY, Yang X, Li YL, Shen XH, Liu Y, Chen ZQ*, You QS*, Shi QH*, Single-Cell Sequencing-Guided Annotation of Rare Tumor Cells for Deep Learning-Based Cytopathologic Diagnosis of Early Lung Cancer, Adv. Sci. 2025, 2416921.

2.Yang L, Yan XW, Chen J, Zhan Q, Hua YQ, Xu SL, Li ZM, Wang Z, Dong Y, Zuo DQ, Xue M, Tang Y, Herschman HR, Lu S*, Shi QH*, Wei W*, Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients, Proc. Natl. Acad. Sci. USA, 2021, 118, e2012228118.

3.Li ZM, Wang Z, Tang Y, Lu X, Chen J, Dong Y, Wu BJ, Wang CY, Yang L, Guo ZL, Xue M, Lu S*, Wei W*, Shi QH*Liquid Biopsy-Based Single-Cell Metabolic Phenotyping of Lung Cancer Patients for Informative DiagnosticsNat. Commun. 2019, 3856.

4.Shen XH, Dai J, Guo LC, Liu ZG, Yang L, Gu DM, Xie YH, Wang Z, Li ZM*, Xu HM*, Shi QH*, Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis, npj Precision Oncology 2024, 8, 30.

5.Zhang ZY, Liu ZG, Chen L, Wang Z, Zhai YY, Qian PY, Zhao YC, Zhu L, Jiang HW*, Wu XB*, Shi QH*, Liquid biopsy-based accurate diagnosis and genomic profiling of hard-to-biopsy tumors via parallel single-cell genomic sequencing of exfoliated tumor cells, Anal. Chem. 2024, 96, 14669-14678.

6.Shen XH, Zhao YC, Wang Z, Shi QH*, Recent advances in high-throughput single-cell transcriptomics and spatial transcriptomics, Lab Chip 2022, 22, 4774-4791.

7.Wang Z, Zhao YY, Shen XH, Zhao YC, Zhang ZY, Yin HM, Zhao XJ*, Liu HT*, Shi QH*, Single-cell genomics-based molecular algorithm for early cancer detection, Anal. Chem. 2022, 94, 2607–2614.

8.Chen J, Yang YB, Wang Z, Shen XH, Zhang ZY, Wang CY, Xu HM*, Shi QH*, A multicancer malignant pleural effusion diagnostic test using hexokinase 2 and single-cell sequencing, Clin. Chem. 2022, 68, 680-690.

9.Wang Z, Chen J, Yang L, Cao MZ, Yu YL, Zhang RL, Quan H, Jiang Q, Hua YQ, Wei W, Lu PH*, Wu J*, Shi QH*, Single-cell sequencing-enabled hexokinase 2 assay for noninvasive bladder cancer diagnosis and screening by detecting rare malignant cells in urine, Anal. Chem. 2020, 92, 16284–16292.

10.Peitzsch C, Gorodeska I, Klusa D, Shi QH, Alves TC, Pantel K, Dubrovska A, Metabolic regulation of prostate cancer heterogeneity and plasticity, Semin. Cancer Biol. 2022, 82, 94-119.

11.Tang Y, Wang Z, Li ZM, Kim J, Deng YL, Li Y, Heath JR, Wei W*, Lu S*, Shi QH*, High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients, Proc. Natl. Acad. Sci. USA, 2017,114, 2544-2549.

        Recommended by Faculty of 1000 Prime

12.Lu Y, Yang L, Wei W*, Shi QH*, Microchip-Based Single-Cell Functional Proteomics for Biomedical Applications, Lab Chip, 2017, 17, 1250-1263.

13.Yang L, Wang ZH, Deng YL, Li Y*, Wei W*, Shi QH*,  Single-Cell, Multiplexed Protein Detection of Rare Tumor Cells Based on a Beads-on-Barcode Antibody Microarray, Anal. Chem. 2016, 88, 11077.

14.Zhang Y, Tang Y, Sun S, Wang ZH, Wu WJ, Zhao XD, Li Y, Wei W, Deng YL*, Shi QH*, Single-cell co-detection of metabolic activity, intracellular functional proteins and genetic mutations from rare circulating tumor cells, Anal. Chem. 2015, 87, 9761

15.Wei W, Shi QH, Remacle F, Qin LD, Shackelford D, Shin YS, Mischel, PS, Levine RD, Heath JR*, Hypoxia Induces a Phase Transition within a Kinase Signaling Network in Cancer Cells, Proc. Natl. Acad. Sci. USA 2013, 110, E1352.

16.Shi QH, Qin LD, Wei W, Geng F, Fan R, Shin YS, Guo DL, Hood L, Mischel PS, Heath JR*, Single-cell proteomic chips for profiling intracellular signaling pathways in single tumor cells, Proc. Natl. Acad. Sci. USA 2012, 109, 419. 

17.Ma C, Fan R, Ahmad H, Shi QH, Comin-Anduix B, Chodon T, Koya, RC, Liu CC, Kwong GA, Radu CG, Ribas A, Heath JR, “A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells”, Nat. Med. 2011, 17, 738.

18.Shi QH, Liang, HJ, Feng D, Wang JF, Stucky GD, “Porous Carbon and Carbon/Metal Oxide Microfibers with Well-Defined    Pore Structure and Interface”, J. Am. Chem. Soc.2008, 130, 5034

19.Shi QH, An, ZS, Tsung C-K, Liang HF, Zheng NF, Hawker CJ, Stucky GD, “Ice-Templating of Core/Shell Microgel Fibers through ‘Bricks-and-Mortar’ Assembly” Adv. Mater.2007,19, 4539.

20.Shi QH, Wang JF, Zhang JP, Fan J, Stucky GD, “Rapid-Setting Mesoporous Bioactive Glass Cements That Induce Accelerated In Vitro Apatite Formation” Adv. Mater. 2006, 18, 1038.

21.Shi QH, Wang JF, Wyrsta MD, Stucky GD, “Vesicle Array-Templated Large-Area Silica Surface Patterns” J. Am. Chem. Soc. 2005, 127, 10154.

22.Zhang F, Shi QH, Zhang YC, Shi YF, Ding KL, Zhao DY, Stucky GD, “Fluorescence Upconversion Microbarcodes for Multiplexed Biological Detection: Nucleic Acid Encoding”, Adv. Mater. 2011, 23, 3775.

23.Wang P, Shi QH, Shi YF, Clark KK, Stucky GD, Keller AA, “Magnetic Permanently Confined Micelle Arrays for Treating Hydrophobic Organic Compound Contamination”, J. Am. Chem. Soc. 2009, 131, 182.

24.An ZS, Shi QH, Tsung C-K,    Hawker CJ, Stucky GD, “Facile RAFT Precipitation Polymerization for the Synthesis of Well-Defined, Dual Hydrophilic Block Copolymers and Nanostructured Hydrogels Assisted by Microwave”, J. Am. Chem. Soc. 2007, 129, 14493.

25.Ostomel, TA, Shi QH, Stucky GD, “Oxide Hemostatic Activity” J. Am. Chem. Soc.2006, 128, 8384.

26.Yang HF, Shi QH, Tian BZ, Lu QY, Gao F, Xie SH, Fan J, Yu CZ, Tu B, Zhao DY, “One-step nanocasting synthesis of highly ordered single crystalline indium oxide nanowire arrays from mesostructured frameworks” J. Am. Chem. Soc. 2003, 125, 4724.

27.Yang HF#, Shi QH#, Tian BZ, Xie SH, Zhang FQ, Yan Y, Tu B, Zhao DY, “A fast way for preparing crack-free mesostructured silica monolith” Chem. Mater. 2003, 15, 536 (#equal author).

28.Yang HF#, Shi QH#, Liu XY, Xie SH, Jiang DC, Zhang FQ, Yu CZ, Tu B, Zhao DY, “Synthesis of ordered mesoporous carbon monoliths with bicontinuous cubic pore structure of Ia3d symmetry” Chem. Commun. 2002, 23, 2842 (#equal author).

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