全聘课题组长
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  • 施奇惠

    博士、研究员、博士生导师
    地址:上海市东安路 131号,复旦大学生物医学研究院
    邮箱:qihuishi@fudan.edu.cn


工作经历
研究员,复旦大学,生物医学研究院(2018-今)
教授,上海交通大学,系统生物医学研究院(2011-2018)
博士后,加州理工学院,化学与化工学院(2008-2011)
教育经历
博士,加州大学圣巴巴拉分校,化学(2003-2008)
学士,复旦大学,化学(1999-2003)
所获人才项目
上海市优秀学术带头人(2023-2026)
国家自然科学基金青年基金(2013-2015)、面上项目(2014-2017、2018-2021、2024-2027)
国家重点研发计划“智能传感器”重点专项(2023-2026)
上海市自然科学基金原创探索项目(2020-2023)
国家重点研发计划“精准医学研究”重点专项(2016-2018)
上海市浦江人才计划(2012)
国家级青年人才项目(2012)
所获奖项
上海市科技进步一等奖(2023,4/6)
中华医学科技奖二等奖(2021,3/10)
上海医学科技奖一等奖(2023,5/7)
上海中医药科技奖一等奖(2023,4/12)
上海中西医结合科学技术奖二等奖(2020,3/7)
研究方向
课题组主要从事液体活检、单细胞测序与人工智能方面的研究,发展无/低创的基于体液的脱落/循环肿瘤细胞检测、溯源方法用于癌症诊断、预后以及定制个体化治疗。
招生专业
生物化学与分子生物学
代表论文

1.     Li ZM, Wang Z, Tang Y, Lu X, Chen J, Dong Y, Wu BJ, Wang CY, Yang L, Guo ZL, Xue M, Lu S*, Wei W*, Shi QH*, Liquid Biopsy-Based Single-Cell Metabolic Phenotyping of Lung Cancer Patients for Informative Diagnostics, Nat. Commun. 2019, 3856.

2.     Yang L, Yan XW, Chen J, Zhan Q, Hua YQ, Xu SL, Li ZM, Wang Z, Dong Y, Zuo DQ, Xue M, Tang Y, Herschman HR, Lu S*, Shi QH*, Wei W*, Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients, Proc. Natl. Acad. Sci. USA, 2021, 118, e2012228118.

3.     Shen XH, Dai J, Guo LC, Liu ZG, Yang L, Gu DM, Xie YH, Wang Z, Li ZM*, Xu HM*, Shi QH*, Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis, npj Precision Oncology 2024, 8, 30.

4.     Zhang ZY, Liu ZG, Chen L, Wang Z, Zhai YY, Qian PY, Zhao YC, Zhu L, Jiang HW*, Wu XB*, Shi QH*, Liquid biopsy-based accurate diagnosis and genomic profiling of hard-to-biopsy tumors via parallel single-cell genomic sequencing of exfoliated tumor cells, Anal. Chem. 2024, 96, 14669-14678.

5.     Shen XH, Zhao YC, Wang Z, Shi QH*, Recent advances in high-throughput single-cell transcriptomics and spatial transcriptomics, Lab Chip 2022, 22, 4774-4791.

6.     Wang Z, Zhao YY, Shen XH, Zhao YC, Zhang ZY, Yin HM, Zhao XJ*, Liu HT*, Shi QH*, Single-cell genomics-based molecular algorithm for early cancer detection, Anal. Chem. 2022, 94, 2607–2614.

7.     Chen J, Yang YB, Wang Z, Shen XH, Zhang ZY, Wang CY, Xu HM*, Shi QH*, A multicancer malignant pleural effusion diagnostic test using hexokinase 2 and single-cell sequencing, Clin. Chem. 2022, 68, 680-690.

8.     Wang Z, Chen J, Yang L, Cao MZ, Yu YL, Zhang RL, Quan H, Jiang Q, Hua YQ, Wei W, Lu PH*, Wu J*, Shi QH*, Single-cell sequencing-enabled hexokinase 2 assay for noninvasive bladder cancer diagnosis and screening by detecting rare malignant cells in urine, Anal. Chem. 2020, 92, 16284–16292.

9.     Peitzsch C, Gorodeska I, Klusa D, Shi QH, Alves TC, Pantel K, Dubrovska A, Metabolic regulation of prostate cancer heterogeneity and plasticity, Semin. Cancer Biol. 2022, 82, 94-119.

10.   Tang Y, Wang Z, Li ZM, Kim J, Deng YL, Li Y, Heath JR, Wei W*, Lu S*, Shi QH*, High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients, Proc. Natl. Acad. Sci. USA, 2017,114, 2544-2549.

        Recommended by Faculty of 1000 Prime

11Wei W, Shi QH, Remacle F, Qin LD, Shackelford D, Shin YS, Mischel, PS, Levine RD, Heath JR*, Hypoxia Induces a Phase Transition within a Kinase Signaling Network in Cancer Cells, Proc. Natl. Acad. Sci. USA 2013, 110, E1352.

12Shi QH, Qin LD, Wei W, Geng F, Fan R, Shin YS, Guo DL, Hood L, Mischel PS, Heath JR*, Single-cell proteomic chips for profiling intracellular signaling pathways in single tumor cells, Proc. Natl. Acad. Sci. USA 2012, 109, 419. 


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