全聘课题组长
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  • 施奇惠

    博士、研究员、博士生导师
    地址:上海市东安路 131号,复旦大学生物医学研究院
    邮箱:qihuishi@fudan.edu.cn

     


工作经历
研究员,复旦大学,生物医学研究院(2018-今)
教授,上海交通大学,系统生物医学研究院(2011-2018)
博士后,加州理工学院,化学与化工学院(2008-2011)
教育经历
博士,加州大学圣巴巴拉分校,化学(2003-2008)
学士,复旦大学,化学(1999-2003)
所获人才项目
国家自然科学基金青年基金(2012)、面上项目(2013、2017)
国家重点研发计划“精准医学研究”重点专项(2016)
上海市浦江人才计划(2012)
研究方向
课题组主要从事液体活检与单细胞分析,发展新的技术与生物标志物用于循环肿瘤细胞(肿瘤液体活检)、循环胎儿细胞(无创产检)等的分离与单细胞测序,探索其用于临床诊断、预后、疗效预测及定制个体化治疗等方面的应用。
代表论文

1. Dong Y, Wang Z, Shi QH*, "Liquid biopsy based single-cell transcriptome profiling characterizes heterogeneity of disseminated tumor cells from lung adenocarcinoma", Proteomics 2020, Online.

2. Li ZM, Wang Z, Tang Y, Lu X, Chen J, Dong Y, Wu BJ, Wang CY, Yang L, Guo ZL, Xue M, Lu S*, Wei W*, Shi QH*, "Liquid biopsy-based single-cell metabolic phenotyping of lung cancer patients for informative diagnostics", Nat. Commun. 2019, 3856.

3. Wang CY, Yang L, Wang Z, He JJ, Shi QH*, "Highly multiplexed profiling of cell surface proteins on single circulating tumor cells based on antibody and cellular barcoding", Anal. Bioanal. Chem., 2019, 411, 5373–5382.

4. Li LM, Yan SQ, Lin BC, Shi QH*, Lu Y*, "Single-cell proteomics for cancer immunotherapy", Adv. Cancer Res., 2018, 139, 185-207.

5. Tang Y, Wang Z, Li ZM, Kim J, Deng YL, Li Y, Heath JR, Wei W*, Lu S*, Shi QH*, "High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients", Proc. Natl. Acad. Sci. USA, 2017,114, 2544-2549 (Recommended by Faculty of 1000 Prime).

6. Su YP, Shi QH*, Wei W*, "Single cell proteomics in biomedicine: high-dimensional data acquisition, visualization and analysis", Proteomics, 2017, 17, 1600267.

7. Lu Y, Yang L, Wei W*, Shi QH*, "Microchip-based single-cell functional proteomics for biomedical applications", Lab Chip, 2017, 17, 1250-1263

8. Yang L, Wang ZH, Deng YL, Li Y*, Wei W*, Shi QH*, " Single-cell, multiplexed protein detection of rare tumor cells based on a beads-on-barcode antibody microarray", Anal. Chem. 2016, 88, 11077.

9. Zhang Y, Tang Y, Sun S, Wang ZH, Wu WJ, Zhao XD, Li Y, Wei W, Deng YL*, Shi QH*, "Single-cell co-detection of metabolic activity, intracellular functional proteins and genetic mutations from rare circulating tumor cells", Anal. Chem. 2015, 87, 9761.

10. Wei W, Shi QH, Remacle F, Qin LD, Shackelford D, Shin YS, Mischel, PS, Levine RD, Heath JR*, “Hypoxia Induces a Phase Transition within a Kinase Signaling Network in Cancer Cells”, Proc. Natl. Acad. Sci. USA 2013, 110, E1352.

11. Shi QH, Qin LD, Wei W, Geng F, Fan R, Shin YS, Guo DL, Hood L, Mischel PS, Heath JR*, “Single-cell proteomic chips for profiling intracellular signaling pathways in single tumor cells”, Proc. Natl. Acad. Sci. USA 2012, 109, 419.


 


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