全聘课题组长
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  • 孙蕾

    博士,青年研究员,博士生导师,复旦大学附属上海市第五人民医院兼职教授

    地址:东安路 131号,上海 200032 

    电话:021-54237007 (办公室)

    传真:021-54237325 (传真)

    邮箱:llsun@fudan.edu.cn


工作经历
青年研究员       复旦大学,生物医学研究院,(2017.07-今)
研究助理教授美国德克萨斯大学西南医学中心,(2016.09-2017.06)
助理研究员    美国普渡大学,(2014.3-2016.8)
博士后    美国普渡大学,(2010.11-2014.2)
博士后        荷兰瓦赫宁根大学,(2006.9-2008.8)
教育经历
博士中国科学院生物物理所,生物物理学,(2001-2006)
学士清华大学,生物科学与技术系,(1997-2001)
研究方向
课题组研究方向为病毒及机体免疫蛋白结构生物学,综合利用分子生物学,生物化学,X光晶体学及冷冻电镜技术,研究全病毒,病毒蛋白质结构。主要研究方向包括:1)致病病毒结构研究:研究与人体疾病相关病毒,及病毒与抗体,病毒与其受体的复合物的结构,以期找到病毒和病毒受体间相互作用位点,分析病毒侵染细胞的原理,为抗病毒药物及疫苗开发提供基础; 2)噬菌体结构及感染机制研究:基于目前对噬菌体结构及DNA传送感染机制的研究,结合单颗粒冷冻电镜技术,X光晶体学和电子断层扫描技术,继续深入研究噬菌体的结构及感染机制。对噬菌体的感染机制研究可有效促进基因治疗及噬菌体制剂的发展。3)解析机体免疫相关的蛋白质及其复合物的结构,识别免疫应答过程中所涉及的分子反应机理。

迄今为止在Nature、Science、Nature Communications Proceedings of the National Academy of Sciences等国际著名杂志发表SCI论文20余篇,论文被引用上千次。


代表论文

  1. Liu Z*, Xu W*, Chen Z*, Fu W*, Zhan W*, Gao Y*, Zhou J*, Zhou Y, Wu J, Wang Q, Zhang X, Hao A, Wu W, Zhang Q, Li Y, Fan K, Chen R, Jiang Q, Mayer C, Schoofs T, Xie Y, Jiang S, Wen Y, Yuan Z#, Wang K#, Lu L#, Sun L#, Wang Q#. An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein & Cell, 2021  (*Co-first authors, #co-corresponding authors)  

  2. Wang W*, Wang Z*, Yang X*, Gao Y*, Zhang X*, Wang W, Zhao L, Zhang J, Q. Jing Q, Xu Q, Cao L, Tian Y, Sun J, Sun L, Jiang L#, Chen Z#, Wang L#. The molecular mechanism of cytoadherence to placenta or tumor cells through VAR2CSA from Plasmodium falciparum. Cell Discovery,2021 (in press)

  3. Yue T*, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B#. SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science, 2021, 372 (6543)

  4. Zhao Y*, Du X*, Duan Y*, Pan X*, Sun Y*, You T*, Han L*, Jin Z, Shang W, Yu J, Guo H, Liu Q, Wu Y, Peng C, Wang J, Zhu C, Yang X, Yang K, Lei Y, Guddat LW, Xu W, Xiao G, Sun L#, Zhang L#, Rao Z# & Yang H#. High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein & Cell, 2021 (in press) (*Co-first authors, #co-corresponding authors)

  5. Cheng Z, Zhang M, Lin H; Gao C, Song J, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun Y, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan K, Xiong Y, Zhang M, Ye D. The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Rep, 2020, 32 (2)

  6. Hu Y, Sun L#. Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses. ACS Infect Dis. 2019, 12;5(7):1070-1080

  7. Sevvana M, Long F, Miller AS, Klose T, Buda G, Sun L, Kuhn RJ, and Rossmann MG. (2018). Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 Å Resolution. Structure,2018, 26, 1169-1177 e1163.

  8. Chen Z*, Sun L*, Zhang Z*, Fokine A, Padilla-Sanchez V, Hanein D, Jiang W, Rossmann MG*; Rao VB.* Cryo-EM structure of the bacteriophage T4 isometric head at 3.3 Å resolution and its relevance to the assembly of icosahedral viruses. Proc Natl Acad Sci U S A, 2017, 114(39): E8184-E8193

  9. Sirohi D*, Chen Z*.Sun L, Klose T.,Rossmann MG, Kuhn RJ. 3.8 ÅCryo-EM structure of Zika Virus. Science, 2016, 352(6284):467-70.doi: 10.1126/science.aaf5316

  10. Sun L*, Zhang X*, Gao S*, Rao PA, Padilla-Sanchez V, Chen Z, Sun S, Xiang Y, Sriram S, Rao VB and Rossmann MG. Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nat. Commun. 2015, 6:7548, doi: 10.1038/ncomms8548

  11. Sun L, Rossmann MG, and Fane BA. High-Resolution Structure of a Virally Encoded DNA-Translocating Conduit and the Mechanism of DNA Penetration. J Virol. 2014, 88: 10276-9

  12. Zhang X, Sun L, Rossmann MG. Temperature dependent conformational change of dengue virus. Current opinion in virology, 2015, 12: 109-112

  13. Sun L*, Young LN*, Zhang X*, Boudko SP, Fokine A, Zbornik E, Roznowski AP, Molineux IJ, Rossmann MG, and Fane BA. Icosahedral PhiX174 forms a tail for DNA transport during infection. Nature. 2014, 505: 432- 435

  14. Wu H*, Sun L*, Blombach F*, Brouns SJ, Snijders AP, Lorenzen K, van den Heuvel RH, Heck AJ, Fu S, Li X, Zhang XC, Rao Z, van der Oost J. Structure of the ribosome associating GTPase HflX.Proteins.2010: 78: 705-713.

  15. Levisson M*, Sun L*, Hendriks S, Swinkels P, Akveld T, Bultema JB, Barendregt A, van den Heuvel RH, Dijkstra BW, van der Oost J, Kengen SW. Crystal structure and biochemical properties of a novel thermostable esterase containing an immunoglobulin-like domain. J Mol Biol. 2009, 385: 949-962

  16. Sun L, Levisson M, Hendriks S, Akveld T, Kengen SW, Dijkstra BW, van der Oost J. Crystallization and preliminary crystallographic analysis of an esterase with a novel domain from the hyperthermophile Thermotoga maritima. Acta Cryst. F2007, 63: 777-779

  17. Sun L, Bartlam M, Liu Y, Pang H, Rao Z. Crystal structure of the pyridoxal-5'-phosphate dependent serine dehydratase from human liver. Protein Sci.2005, 14: 791-798

  18. Sun L, Dong Y, Zhou Y, Yang M, Zhang C, Rao Z, Zhang XE. Crystallization and preliminary X-ray studies of methyl parathion hydrolase from Pseudomonas sp. WBC-3. Acta Cryst. D 2005,60: 954-956

  19. Sun L, Li X, Dong Y, Yang M, Liu Y, Han X, Zhang X, Pang H, Rao Z. Crystallization and preliminary crystallographic analysis of human serine dehydratase. Acta Cryst. D 2003 59: 2297-2299

  20. Yang H, Yang M, Ding Y, Liu Y, Lou, Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A 2003, 100 (23), 13190-5.

  



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