全聘课题组长
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  • 孙蕾

    研究员,博士生导师
    地址:徐汇区东安路131号科研二号楼,上海 200032
    邮箱:LLSun@fudan.edu.cn

工作经历
研究员,复旦大学,生物医学研究院/上海市第五人民医院(2024-今)
青年研究员,复旦大学,生物医学研究院/上海市第五人民医院(2017-2023)
研究助理教授,美国德克萨斯大学西南医学中心(2016-2017)
助理研究员,美国普渡大学(2010-2016)
博士后,荷兰瓦赫宁根大学(2006-2008)
教育经历
博士,中国科学院生物物理所,生物物理学(2001-2006)
学士,清华大学,生物科学与技术系(1997-2001)
研究方向
课题组研究方向为病毒结构生物学及转化医学,主要利用冷冻电镜技术,综合分子生物学,生物化学,研究全病毒,病毒蛋白质的结构,并基于此进行抗病毒策略研究。主要研究方向包括:1)致病病毒结构研究:研究与人体疾病相关病毒,及病毒与抗体,病毒与其受体的复合物的结构,分析病毒感染机制,指导抗病毒药物开发;2)基于结构的抗体设计:基于结构揭示不同抗体的表位及靶向机制,并对抗体进行改造,提高其广谱性及可吸收性;3) 基于结构的疫苗设计:综合结构生物学,生物信息学分析,进行广谱免疫原设计。迄今为止在Nature、Science、Cell、Cell Research, Nature Communications等国际著名杂志发表SCI论文50余篇,论文被引用上千次。
招生专业
医学系统生物学
代表论文

1.Qiu Y, Sun L. Decoding WEEV's host adaptation. Cell Host Microbe2025, 33(5): 610-612. (Preview)

2.Xing LX, Liu ZM, Wang XL, Liu QY, Xu W, Mao QY, Zhang X, Hao AH, Xia S, Liu ZZ, Sun LJ, Zhang GX, Wang Q, Chen ZG, Jiang SB*, Sun L*, Lu L*. Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target. Cell2025, 188(5).

3.Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z*, Beutler B*, Sun L*. Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3(KBTBD2). Nat Struct Mol Biol2024, 31(2): 336-350.

4.Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L*; Rao Z*; Yang H*. TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell2024, 187(16): 4261-4271 e4217.

5.Wang Y, Hao A, Ji P, Ma Y, Zhang Z, Chen J, Mao Q, Xiong X, Rehati P, Wang Y, Wang Y, Wen Y, Lu L, Chen Z, Zhao J*; Wu F,*; Huang J,*; Sun L*. A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and Sarbecoviruses. Nat Commun2024, 15(1): 5127.

6.Zhao X, Qiu T, Huang X, Mao Q, Wang Y, Qiao R, Li J, Mao T, Wang Y, Cun Y, Wang C, Luo C, Yoon C, Wang X, Li C, Cui Y, Zhao C, Li M, Chen Y, Cai G, Geng W, Hu Z, Cao J, Zhang W, Cao Z, Chu H, Sun L, Wang P. Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov2024, 10(1): 14.

7.Hao A, Song W, Li C, Zhang X, Tu C, Wang X, Wang P, Wu Y*, Ying T*, Sun L*. Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants. Signal Transduct Tar2023, 8(1).

8.Wu J, Chen Z, Gao Y, Wang Z, Wang J, Chiang BY, Zhou Y, Han Y, Zhan W, Xie M, Jiang W, Zhang X, Hao A, Xia A, He J, Xue S, Mayer CT, Wu F, Wang B, Zhang L*, Sun L*, Wang Q*. Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants. Cell Rep2023, 42(5): 112503.

9.Wang H, Yang Q, Liu X, Xu Z, Shao M, Li D, Duan Y, Tang J, Yu X, Zhang Y, Hao A, Wang Y, Chen J, Zhu C, Guddat L, Chen H, Zhang L*, Chen X*, Jiang B*, Sun L*, Rao Z, Yang H*. Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun2023, 14(1): 7574.

10.Ma Y, Mao Q, Wang Y, Zhang Z, Chen J, Hao A, Rehati P, Wang Y, Wen Y, Lu L, Chen Z, Zhao J*, Wu F*, Sun L*, Huang J*. A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity. Cell Res2023.

11.Liu Q, Zhang X, Huang H, Chen Y, Wang F, Hao A, Zhan W, Mao Q, Hu Y, Han L, Sun Y, Zhang M, Liu Z, Li GL, Zhang W, Shu Y*, Sun L*, Chen Z*. Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger. Nat Commun2023, 14(1): 3012.

12.Zhan W, Tian X, Zhang X, Xing S, Song W, Liu Q, Hao A, Hu Y, Zhang M, Ying T*, Chen Z*, Lan F*, Sun L*. Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer. J Virol2022, 96(16): e0048022.

13.Li C, Zhan W, Yang Z, Tu C, Hu G, Zhang X, Song W, Du S, Zhu Y, Huang K, Kong Y, Zhang M, Mao Q, Gu X, Zhang Y, Xie Y, Deng Q, Song Y, Chen Z, Lu L, Jiang S, Wu Y*, Sun L*, Ying T*. Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell2022, 185(8): 1389-1401 e1318.

14.Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J*, Wu F*, Sun L*, Huang J*. A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Res2022, 32(9): 862-865.

15.Liu Z, Xu W, Chen Z, Fu W, Zhan W, Gao Y, Zhou J, Zhou Y, Wu J, Wang Q, Zhang X, Hao A, Wu W, Zhang Q, Li Y, Fan K, Chen R, Jiang Q, Mayer CT, Schoofs T, Xie Y, Jiang S, Wen Y, Yuan Z*, Wang K*, Lu L*, Sun L*, Wang Q*. An ultrapotent pan-beta-coronavirus lineage B (beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein Cell2022, 13(9): 655-675.

16.Hu Y, Sun L*. Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses. ACS Infect Dis2019, 5(7): 1070-1080.

 

Before 2017:

1.Chen Z, Sun L#, Zhang Z, Fokine A, Padilla-Sanchez V, Hanein D, Jiang W, Rossmann MG*, Rao VB*. Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-A resolution and its relevance to the assembly of icosahedral viruses. Proc Natl Acad Sci U S A2017, 114(39): E8184-E8193.

2.Sun L#, Zhang X, Gao S, Rao PA, Padilla-Sanchez V, Chen Z, Sun S, Xiang Y, Subramaniam S, Rao VB*, Rossmann MG*. Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nat Commun2015, 6: 7548.

3.Sun L#, Young LN, Zhang X, Boudko SP, Fokine A, Zbornik E, Roznowski AP, Molineux IJ, Rossmann MG*, Fane BA*. Icosahedral bacteriophage PhiX174 forms a tail for DNA transport during infection. Nature2014, 505(7483): 432-435.

4.Sun L#, Rossmann MG*, Fane BA*. High-resolution structure of a virally encoded DNA-translocating conduit and the mechanism of DNA penetration. J Virol2014, 88(18): 10276-10279.

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