全聘课题组长
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  • 孙蕾

    青年研究员,博士生导师
    地址:徐汇区东安路131号科研二号楼,上海 200032
    邮箱:llsun@fudan.edu.cn

工作经历
青年研究员,复旦大学,生物医学研究院/上海市第五人民医院(2017.07-今)
研究助理教授,美国德克萨斯大学西南医学中心(2016.09-2017.06)
助理研究员,美国普渡大学(2010.11-2016.8)
博士后,荷兰瓦赫宁根大学(2006.9-2008.8)
教育经历
博士,中国科学院生物物理所,生物物理学(2001-2006)
学士,清华大学,生物科学与技术系(1997-2001)
研究方向
课题组研究方向为病毒及机体免疫蛋白结构生物学,综合利用分子生物学,生物化学,X光晶体学及冷冻电镜技术,研究全病毒,病毒蛋白质的结构。主要研究方向包括:1)致病病毒结构研究:研究与人体疾病相关病毒,及病毒与抗体,病毒与其受体的复合物的结构,以期找到病毒和病毒受体间相互作用位点,分析病毒侵染细胞的原理,为抗病毒药物及疫苗开发提供基础;2)解析机体免疫相关的蛋白质及其复合物的结构,识别免疫应答过程中所涉及的分子反应机理。

迄今为止在Nature、Science、Cell、Nature Communications、Proceedings of the National Academy of Sciences及 Protein&Cell等国际著名杂志发表SCI论文30余篇,论文被引用上千次

代表论文

1.Zhan, W.; Tian, X.; Zhang, X.; Xing, S.; Song.W.; Liu, Q.; Hao, A.; Hu,Y., Zhang, M.; Ying, T.*;Chen, Z.*; Lan, F.1*; Sun, L.*, Structural study of SARS-CoV-2 antibodies identifies a broad-spectrum antibody that neutralizes Omicron variant by disassembling the spike trimer. Journal of Virology, 2022, (in press) (*共通讯作者)

2.Li, C.; Zhan, W.; Yang, Z.; Tu, C.; Hu, G.; Zhang, X.; Song, W.; Du, S.; Zhu, Y.; Huang, K.; Kong, Y.; Zhang, M.; Mao, Q.; Gu, X.; Zhang, Y.; Xie, Y.; Deng, Q.; Song, Y.; Chen, Z.; Lu, L.; Jiang, S.; Wu, Y.*; Sun, L.*; Ying, T.*, Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell 2022,185 (8), 1389-1401 e18. (*共通讯作者)

3.Wang, Y.; Zhan, W.; Liu J.; Wang, Y.; Zhang, X.; Zhang, M.; Han, L.; Ma, Y.; Lu, L.; Wen, Y.; Chen, Z.; Zhao, J. *; Wu, F. *; Sun, L. * and Huang, J. *, A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Research, 2022, doi:10.1038/s41422-022-00684-0 (*共通讯作者)

4.Liu, Z.; Xu, W.; Chen, Z.; Fu, W.; Zhan, W.; Gao, Y.; Zhou, J.; Zhou, Y.; Wu, J.; Wang, Q.;Zhang, X.; Hao, A.; Wu, W.; Zhang, Q.; Li, Y.; Fan, K.; Chen, R.; Jiang, Q.; Mayer, C. T.;Schoofs, T.; Xie, Y.; Jiang, S.; Wen, Y.; Yuan, Z.*; Wang, K.*; Lu, L.*; Sun, L.*; Wang, Q.*, An ultrapotent pan-beta-coronavirus lineage B (beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein&Cell 2022, 13(9): 655–675.. (*共通讯作者)

5.Zhao, Y.; Du, X.; Duan, Y.; Pan, X.; Sun, Y.; You, T.; Han, L.; Jin, Z.; Shang, W.; Yu, J.;Guo, H.; Liu, Q.; Wu, Y.; Peng, C.; Wang, J.; Zhu, C.; Yang, X.; Yang, K.; Lei, Y.; Guddat, L. W.; Xu, W.; Xiao, G.; Sun, L.*; Zhang, L.*; Rao, Z.*; Yang, H.*, High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein&Cell 2021,12 (11), 877-888. (*共通讯作者)

6.Yue, T.; Zhan, X.; Zhang, D.; Jain, R.; Wang, K. W.; Choi, J. H.; Misawa, T.; Su, L.; Quan, J.;Hildebrand, S.; Xu, D.; Li, X.; Turer, E.; Sun, L.; Moresco, E. M. Y.; Beutler, B.*, SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science 2021,372 (6543).

7.Hu, Y.; Sun, L.*, Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses. ACS Infect Dis 2019,5 (7), 1070-1080.

8.Chen, Z.#; Sun, L.#; Zhang, Z.#; Fokine, A.; Padilla-Sanchez, V.; Hanein, D.; Jiang, W.;Rossmann, M. G.*; Rao, V. B.*, Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-A resolution and its relevance to the assembly of icosahedral viruses. Proc Natl Acad Sci U S A 2017,114 (39), E8184-E8193. (# 共同第一作者)

9.Sirohi, D.; Chen, Z.; Sun, L.; Klose, T.; Pierson, T. C.; Rossmann, M. G.*; Kuhn, R. J.*, The 3.8 A resolution cryo-EM structure of Zika virus. Science 2016,352 (6284), 467-70.

10.Sun, L.#; Zhang, X.#; Gao, S.#; Rao, P. A.; Padilla-Sanchez, V.; Chen, Z.; Sun, S.; Xiang, Y.; Subramaniam, S.; Rao, V. B.*; Rossmann, M. G.*, Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nat Commun 2015,6, 7548.

11.Sun, L.; Young, L. N.; Zhang, X.; Boudko, S. P.; Fokine, A.; Zbornik, E.; Roznowski, A. P.; Molineux, I. J.; Rossmann, M. G.*; Fane, B. A.*, Icosahedral bacteriophage PhiX174 forms a tail for DNA transport during infection. Nature 2014,505 (7483), 432-5.

12.Sun, L.; Rossmann, M. G.*; Fane, B. A.*, High-resolution structure of a virally encoded DNA-translocating conduit and the mechanism of DNA penetration. J Virol2014,88 (18), 10276-9.

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