青年研究员，博士生导师
地址：徐汇区东安路131号科研二号楼，上海 200032
邮箱：llsun@fudan.edu.cn
迄今为止在Nature、Science、Cell、Nature Communications、Proceedings of the National Academy of Sciences及 Protein&Cell等国际著名杂志发表SCI论文30余篇，论文被引用上千次。
2.Wu, J.; Chen, Z.; Gao, Y.; Wang, Z.; Wang, J.; Chiang, B. Y.; Zhou, Y.; Han, Y.; Zhan, W.; Xie, M.; Jiang, W.; Zhang, X.; Hao, A.; Xia, A.; He, J.; Xue, S.; Mayer, C. T.; Wu, F.; Wang, B.; Zhang, L.; Sun, L.*; Wang, Q.*, Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants. Cell Rep 2023,42 (5), 112503.
3.Liu, Q.; Zhang, X.; Huang, H.; Chen, Y.; Wang, F.; Hao, A.; Zhan, W.; Mao, Q.; Hu, Y.; Han, L.; Sun, Y.; Zhang, M.; Liu, Z.; Li, G.; Zhang, W.; Shu, Y.*; Sun, L.*; Chen, Z.*, Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger. Nat Commun 2023,14 (1).
4.Li, S.; Wu, J.; Jiang, W.; He, H.; Zhou, Y.; Wu, W.; Gao, Y.; Xie, M.; Xia, A.; He, J.; Zhang, Q.; Han, Y.; Wang, N.; Zhu, G.; Wang, Q.; Zhang, Z.; Mayer, C. T.; Wang, K.; Wang, X.; Wang, J.; Chen, Z.*; Jiang, S.*; Sun, L.*; Xia, R.*; Wang, Q.*, Characterization of cross-reactive monoclonal antibodies against SARS-CoV-1 and SARS-CoV-2: Implication for rational design and development of pan-sarbecovirus vaccines and neutralizing antibodies. J Med Virol 2023,95 (2), e28440.
5.Han, L.; Chen, Z.; Sun, L.*, Expression, purification, and microscopic characterization of the tumor suppressor KLHL6. Protein Expr Purif 2023,210, 106318.
6.Li, C.; Zhan, W.; Yang, Z.; Tu, C.; Hu, G.; Zhang, X.; Song, W.; Du, S.; Zhu, Y.; Huang, K.; Kong, Y.; Zhang, M.; Mao, Q.; Gu, X.; Zhang, Y.; Xie, Y.; Deng, Q.; Song, Y.; Chen, Z.; Lu, L.; Jiang, S.; Wu, Y.*; Sun, L.*; Ying, T.*, Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell 2022,185 (8), 1389-1401 e18.
7.Zhan, W.; Tian, X.; Zhang, X.; Xing, S.; Song, W.; Liu, Q.; Hao, A.; Hu, Y.; Zhang, M.; Ying, T.*; Chen, Z.*; Lan, F.*; Sun, L.*, Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer. J Virol 2022,96 (16), e0048022.
8.Wang, Y.; Zhan, W.; Liu J.; Wang, Y.; Zhang, X.; Zhang, M.; Han, L.; Ma, Y.; Lu, L.; Wen, Y.; Chen, Z.; Zhao, J. *; Wu, F. *; Sun, L. * and Huang, J. *, A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Research 2022,32,862-865
9.Wang, Y.; Zhang, X.; Ma, Y.; Wang, Y.; Zhan, W.; Zheng, Q.; Zhang, M.; Ji, P.; Liu, M.; Liu, Q.; Sun, T.; Zhu, T.; Wen, Y.; Sun, L.*; Zhao, J.*; Wu, F.*; Chen, Z.*; Huang, J.*, Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies. Cell Discov 2022,8 (1), 104.
10.Liu, Z.; Xu, W.; Chen, Z.; Fu, W.; Zhan, W.; Gao, Y.; Zhou, J.; Zhou, Y.; Wu, J.; Wang, Q.; Zhang, X.; Hao, A.; Wu, W.; Zhang, Q.; Li, Y.; Fan, K.; Chen, R.; Jiang, Q.; Mayer, C. T.; Schoofs, T.; Xie, Y.; Jiang, S.; Wen, Y.; Yuan, Z.*; Wang, K.*; Lu, L.*; Sun, L.*; Wang, Q.*, An ultrapotent pan-beta-coronavirus lineage B (beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein&Cell 2022,13(9): 655–675.
11.Zhao, Y.; Du, X.; Duan, Y.; Pan, X.; Sun, Y.; You, T.; Han, L.; Jin, Z.; Shang, W.; Yu, J.; Guo, H.; Liu, Q.; Wu, Y.; Peng, C.; Wang, J.; Zhu, C.; Yang, X.; Yang, K.; Lei, Y.; Guddat, L. W.; Xu, W.; Xiao, G.; Sun, L.*; Zhang, L.*; Rao, Z.*; Yang, H. *, High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein&Cell 2021,12 (11), 877-888.
12.Yue, T.; Zhan, X.; Zhang, D.; Jain, R.; Wang, K. W.; Choi, J. H.; Misawa, T.; Su, L.; Quan, J.; Hildebrand, S.; Xu, D.; Li, X.; Turer, E.; Sun, L.; Moresco, E. M. Y.; Beutler, B.*, SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science 2021,372 (6543).
13.Hu, Y.; Sun, L.*, Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses. ACS Infect Dis 2019,5 (7), 1070-1080.
14.Chen, Z.#; Sun, L.#; Zhang, Z.#; Fokine, A.; Padilla-Sanchez, V.; Hanein, D.; Jiang, W.; Rossmann, M. G.*; Rao, V. B.*, Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-A resolution and its relevance to the assembly of icosahedral viruses. Proc Natl Acad Sci U S A 2017,114 (39), E8184-E8193.
15.Sirohi, D.; Chen, Z.; Sun, L.; Klose, T.; Pierson, T. C.; Rossmann, M. G.*; Kuhn, R. J.*, The 3.8 A resolution cryo-EM structure of Zika virus. Science 2016,352 (6284), 467-70.
16.Sun, L.#; Zhang, X.#; Gao, S.#; Rao, P. A.; Padilla-Sanchez, V.; Chen, Z.; Sun, S.; Xiang, Y.; Subramaniam,S.; Rao,V.B.*; Rossmann,M.G.*, Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nat Commun 2015,6, 7548.
17.Sun, L.; Young, L. N.; Zhang, X.; Boudko, S. P.; Fokine, A.; Zbornik, E.; Roznowski, A. P.; Molineux, I. J.; Rossmann, M. G.*; Fane, B. A.*, Icosahedral bacteriophage PhiX174 forms a tail for DNA transport during infection. Nature 2014,505 (7483), 432-5.
18.Sun, L.; Rossmann, M. G.*; Fane, B. A.*, High-resolution structure of a virally encoded DNA-translocating conduit and the mechanism of DNA penetration. J Virol 2014,88 (18), 10276-9.
