代表论文

1. Liu Z*, Xu W*, Chen Z*, Fu W*, Zhan W*, Gao Y*, Zhou J*, Zhou Y, Wu J, Wang Q, Zhang X, Hao A, Wu W, Zhang Q, Li Y, Fan K, Chen R, Jiang Q, Mayer C, Schoofs T, Xie Y, Jiang S, Wen Y, Yuan Z#, Wang K#, Lu L#, Sun L#, Wang Q#. An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein & Cell, 2021  (*Co-first authors, #co-corresponding authors)  

2. Wang W*, Wang Z*, Yang X*, Gao Y*, Zhang X*, Wang W, Zhao L, Zhang J, Q. Jing Q, Xu Q, Cao L, Tian Y, Sun J, Sun L, Jiang L#, Chen Z#, Wang L#. The molecular mechanism of cytoadherence to placenta or tumor cells through VAR2CSA from Plasmodium falciparum. Cell Discovery,2021 (in press)

3. Yue T*, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B#. SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science, 2021, 372 (6543)

4. Zhao Y*, Du X*, Duan Y*, Pan X*, Sun Y*, You T*, Han L*, Jin Z, Shang W, Yu J, Guo H, Liu Q, Wu Y, Peng C, Wang J, Zhu C, Yang X, Yang K, Lei Y, Guddat LW, Xu W, Xiao G, Sun L^#, Zhang L^#, Rao Z^# & Yang H^#. High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein & Cell, 2021 (in press) (*Co-first authors, ^#co-corresponding authors)

5. Cheng Z, Zhang M, Lin H; Gao C, Song J, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun Y, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan K, Xiong Y, Zhang M, Ye D. The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Rep, 2020, 32 (2)

6. Hu Y, Sun L^#. Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses. ACS Infect Dis. 2019, 12;5(7):1070-1080

7. Sevvana M, Long F, Miller AS, Klose T, Buda G, Sun L, Kuhn RJ, and Rossmann MG. (2018). Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 Å Resolution. Structure,2018, 26, 1169-1177 e1163.

8. Chen Z*, Sun L*, Zhang Z*, Fokine A, Padilla-Sanchez V, Hanein D, Jiang W, Rossmann MG*; Rao VB.* Cryo-EM structure of the bacteriophage T4 isometric head at 3.3 Å resolution and its relevance to the assembly of icosahedral viruses. Proc Natl Acad Sci U S A, 2017, 114(39): E8184-E8193

9. Sirohi D*, Chen Z*.Sun L, Klose T.,Rossmann MG, Kuhn RJ. 3.8 ÅCryo-EM structure of Zika Virus. Science, 2016, 352(6284):467-70.doi: 10.1126/science.aaf5316

10. Sun L*, Zhang X*, Gao S*, Rao PA, Padilla-Sanchez V, Chen Z, Sun S, Xiang Y, Sriram S, Rao VB and Rossmann MG. Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nat. Commun. 2015, 6:7548, doi: 10.1038/ncomms8548

11. Sun L, Rossmann MG, and Fane BA. High-Resolution Structure of a Virally Encoded DNA-Translocating Conduit and the Mechanism of DNA Penetration. J Virol. 2014, 88: 10276-9

12. Zhang X, Sun L, Rossmann MG. Temperature dependent conformational change of dengue virus. Current opinion in virology, 2015, 12: 109-112

13. Sun L*, Young LN*, Zhang X*, Boudko SP, Fokine A, Zbornik E, Roznowski AP, Molineux IJ, Rossmann MG, and Fane BA. Icosahedral PhiX174 forms a tail for DNA transport during infection. Nature. 2014, 505: 432- 435

14. Wu H*, Sun L*, Blombach F*, Brouns SJ, Snijders AP, Lorenzen K, van den Heuvel RH, Heck AJ, Fu S, Li X, Zhang XC, Rao Z, van der Oost J. Structure of the ribosome associating GTPase HflX.Proteins.2010: 78: 705-713.

15. Levisson M*, Sun L*, Hendriks S, Swinkels P, Akveld T, Bultema JB, Barendregt A, van den Heuvel RH, Dijkstra BW, van der Oost J, Kengen SW. Crystal structure and biochemical properties of a novel thermostable esterase containing an immunoglobulin-like domain. J Mol Biol. 2009, 385: 949-962

16. Sun L, Levisson M, Hendriks S, Akveld T, Kengen SW, Dijkstra BW, van der Oost J. Crystallization and preliminary crystallographic analysis of an esterase with a novel domain from the hyperthermophile Thermotoga maritima. Acta Cryst. F2007, 63: 777-779

17. Sun L, Bartlam M, Liu Y, Pang H, Rao Z. Crystal structure of the pyridoxal-5'-phosphate dependent serine dehydratase from human liver. Protein Sci.2005, 14: 791-798

18. Sun L, Dong Y, Zhou Y, Yang M, Zhang C, Rao Z, Zhang XE. Crystallization and preliminary X-ray studies of methyl parathion hydrolase from Pseudomonas sp. WBC-3. Acta Cryst. D 2005,60: 954-956

19. Sun L, Li X, Dong Y, Yang M, Liu Y, Han X, Zhang X, Pang H, Rao Z. Crystallization and preliminary crystallographic analysis of human serine dehydratase. Acta Cryst. D 2003 59: 2297-2299

20. Yang H, Yang M, Ding Y, Liu Y, Lou, Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A 2003, 100 (23), 13190-5.