博士生导师,研究员
地址:东安路130号,西13号楼315室,上海 200032
电话:18721014527
邮箱:zhou_feng@fudan.edu.cn
1、创新医疗器械
课题组长周峰联合复旦大学附属眼耳鼻喉科医院研发了独创的液脉动干眼治疗技术。研发的液脉动干眼治疗仪荣获2023年上海市二类创新医疗器械,并已取得NMPA颁发的产品注册证和生产许可证。液脉动干眼治疗仪荣获2024年度上海市春昇杯医疗创新大赛二等奖(第二获奖人)。
2、单细胞功能蛋白质组学
依靠创新的高灵敏度蛋白质组学平台,针对细胞功能蛋白质组进行高通量的检测,多项成果发表在Cell, Nature Cell Biology, Nature Microbiology, Nature Communications, Analytical Chemistry等顶尖杂志。
3、深度高覆盖抗体反应组学
利用构建的抗原库捕捉抗原抗体复合物,借助DEEP SEQ深度蛋白质组学联合免疫共沉淀及磁珠酶解的策略,通过生物信息学分析发现那些在自身免疫、肿瘤等疾病中起到重要作用的的潜在自身抗体。为进一步理解这些疾病的发生发展起到重要作用。成果发表在权威期刊Annals of the Rheumatic Diseases。
[1] Liang, M., Wang, L., Tian, X., Wang, K., Zhu, X., Huang, L., Li, Q., Ye, W., Chen, C., Yang, H., Wu, W., Chen, X., Zhu, X., Xue, Y., Wan, W., Wu, Y., Lu, L., Wang, J., Zou, H., Ying, T., & Zhou, F*. (2024). “Identification and validation of anti-protein arginine methyltransferase 5 (PRMT5) antibody as a novel biomarker for systemic sclerosis (SSc). Annals of the Rheumatic Diseases.” IF: 27.2 (* Corresponding author)
[2] Liu, Y., Y. Fu, Q. Wang, M. Li, Z. Zhou, D. Dabbagh, C. Fu, H. Zhang, S. Li, T. Zhang, J. Gong, X. Kong, W. Zhai, J. Su, J. Sun, Y. Zhang, X.-F. Yu, Z. Shao, F. Zhou*, Y. Wu* and X. Tan* (2019). Proteomic profiling of HIV-1 infection of human CD4+ T cells identifies PSGL-1 as an HIV restriction factor. Nature Microbiology. IF: 14.147 (* Corresponding author)
[3] Liu X, Zhang Y, Chen Y, Li M, Zhou F*, Li K, Cao H, Ni M, Liu Y, Gu Z, Dickerson KE, Xie S, Hon GC, Xuan Z, Zhang MQ, Shao Z, Xu J*. In Situ Capture of Chromatin Interactions by Biotinylated dCas9. Cell. 170(5): 1028-1043. IF: 30.410 (* Corresponding author)
[4] Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F*, Shao Z*, Xu J*. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nature Cell Biology 2017; 19(6): 626-638. IF: 20.062(* Corresponding author)
[5] Lin Z, Li S, Feng C, Yang S, Wang H, Ma D, Zhang J, Gou M, Bu D, Zhang T, Kong X, Wang X, Sarig O, Ren Y, Dai L, Liu H, Zhang J, Li F, Hu Y, Padalon-Brauch G, Vodo D, Zhou F, Chen T, Deng H, Sprecher E, Yang Y, Tan X. Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Nature Genetics. 2016; 48(12): 1508-1516.
[6] Zhou F, Lu Y, Ficarro SB, Adelmant G, Jiang W, Luckey CJ, Marto JA. Genome-scale proteome quantification by DEEP SEQ mass spectrometry. Nature communications. 2013; 4.
[7] Zhou F, Lu Y, Ficarro SB, Webber JT, Marto JA. Nanoflow low pressure high peak capacity single dimension LC-MS/MS platform for high-throughput, in-depth analysis of mammalian proteomes. Analytical chemistry. 2012; 84(11): 5133-5139.
[8] Zhou F, Sikorski TW, Ficarro SB, Webber JT, Marto JA. Online nanoflow reversed phase-strong anion exchange-reversed phase liquid chromatography–tandem mass spectrometry platform for efficient and in-depth proteome sequence analysis of complex organisms. Analytical chemistry. 2011; 83(18): 6996-7005.
[9] Caro P, Kishan Amar U, Norberg E, Stanley IA, Chapuy B, Ficarro Scott B, Polak K, Tondera D, Gounarides J, Yin H, Zhou F, Green Michael R, Chen L, Monti S, Marto Jarrod A, Shipp Margaret A, Danial Nika N. Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma. Cancer Cell. 2012; 22(4): 547-560.