郑海
博士，青年研究员
地址：上海市徐汇区东安路131号明道楼709室，200032
邮箱：zhengh@fudan.edu.cn
1. Zheng, H.#, Qi, Y.#, Hu, S.#, Cao, X.#, Xu, C.#, Yin, Z., Chen, X., Li, Y., Liu, W., Li, J., Wang, J., Wei, G., Liang, K., Chen, F. X.*, and Xu, Y.* (2020) Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science 370, eabb5872.
2. Zheng, H.*#, Jin, Q.#, Wang, X.#, Qi, Y., Liu, W., Ren, Y., Zhao, D., Chen, F. X., Cheng, J., Chen, X., and Xu, Y.* (2023) Structural basis of INTAC-regulated transcription. Protein Cell 14, 698-702.
3. Xu, C.*#, Zhou, Q.#, Zheng, H.#, Song, A.#, Zhao, W., Xu, T., Xiong, Y., Zhang, Y., Huang, Z., Xu, Y.*, Cheng, J.*, and Chen, F. X.* (2025) DSS1 is required for proper Integrator–PP2A function. Nat. Commun.16, 6206.
4. Zheng, H., Miyakawa, T., Sawano, Y., Asano, A., Okumura, A., Yamagoe, S., and Tanokura, M.* (2016) Crystal structure of human leukocyte cell-derived chemotaxin 2 (LECT2) reveals a mechanistic basis of functional evolution in a mammalian protein with an M23 metalloendopeptidase fold. J. Biol. Chem.291, 17133-17142.
5. Zheng, H., Miyakawa, T., Sawano, Y., Yamagoe, S., and Tanokura, M.* (2013) Expression, high-pressure refolding and purification of human leukocyte cell-derived chemotaxin 2 (LECT2). Protein Expr. Purif.88, 221-229.
6. Wang, Z.#, Song, A.#, Xu, H.#, Hu, S., Tao, B., Peng, L., Wang, J., Li, J., Yu, J., Wang, L., Li, Z., Chen, X., Wang, M., Chi, Y., Wu, J., Xu, Y., Zheng, H., and Chen, F. X* (2022) Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1. Sci. Adv. 8, eabm5504.
7. Xu, C.#, Li, C.#, Chen, J.#, Xiong, Y.#, Qiao, Z., Fan, P., Li, C., Ma, S., Liu, J., Song, A., Tao, B., Xu, T., Xu, W., Chi, Y., Xue, J., Wang, P., Ye, D., Gu, H., Zhang, P., Wang, Q., Xiao, R., Cheng, J., Zheng, H., Yu, X., Zhang, Z., Wu, J., Liang, K., Liu, Y. J., Lu, H.* and Chen, F. X.* (2023) R-loop-dependent promoter-proximal termination ensures genome stability. Nature 621, 610-619.
8. Fan, P.#, Shang, X. Y.#, Song, A.#, Chen, S.#, Mao, R. Y., Ma, J., Chen, J., Wang, Z., Zheng, H., Tao, B., Hong, L., Liu, J., Xu, W., Jiang, W., Shen, H., Zhang, Q., Yang, H., Meng, X. M., Lan, F., Cheng, J., Xu, C., Zhang, P.*, Jiang. H.*, Chen, F. X.* (2025) Catalytic-independent functions of the Integrator–PP2A complex (INTAC) confer sensitivity to BET inhibition. Nat. Chem. Biol. 21, 959–970.
