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  • 罗敏

    博士,研究员,博士生导师
    地址:东安路 131号东区,科研2号楼A2-020,上海 200032
    邮箱:luo_min@fudan.edu.cn 



工作经历
研究员,复旦大学生物医学研究院,附属儿科医院兼职教授(2018. 01-今)
助理研究员,美国西南医学研究中心(2013.3-2018.1)
副研究员,深圳市疾病预防控制中心(2010.9-2013.03)
讲师,北京大学(2007.10-2010.8)
博士后,北京大学(2005.10-2007.9)
教育经历
博士,北京大学,生命科学学院(2000.9 – 2005.7)
学士,北京大学,生命科学学院(1996.9 – 2000.7)
所获人才项目
国家级青年人才项目(2018)
东方英才计划领军项目(2023)
所获奖项
复旦大学十大科技进展(2023)
 “一健康”优秀教师奖(2024)
研究方向
长期从事肿瘤免疫研究,围绕细胞表面受配体的识别与调控,在免疫治疗新靶点和药物策略等方面进行了多项前沿性探索,并推动成果向临床治疗转化。发现肿瘤中性粒细胞细胞表面新的免疫抑制受体CD300ld,在肿瘤免疫微环境的建立及肿瘤进展中发挥关键作用;建立全基因组水平受配体互作筛选体系,为孤儿受配体的解码提供有力工具;开发一种能同时激活STING从而高效呈递T细胞活化信号的新型肿瘤纳米疫苗,解析其作用及增效机制并推动进入I期临床。申请/授权中国专利3项、PCT专利2项,主持国家自然科学基金专项和面上多项。
招生专业
生物化学与分子生物学
代表论文

1.Wang C, Zheng X, Zhang J, Jiang X, Wang J, Li Y, Li X, Shen G, Peng J, Zheng P, Gu Y, Chen J, Lin M, Deng C, Gao H*, Lu Z*, Zhao Y*, Luo M*. CD300ld on neutrophils is required for tumour-driven immune suppression. Nature. 2023 Sep, 621(7980):830-839. (*: corresponding)

2.Li Y, Fang M, Yu H, Wang X, Xue S, Jiang Z, Huang Z, Rong S, Wei X, Lu Z, Luo M*.Nature communication. 2025 May 23;16(1):4783. (*: corresponding)

3.Ding H, Li Y, Fang M, Chen J, Liu L, Lu Z*, Hou J*, and Luo M*. Epigenetic activation of the TUSC3 gene as a potential therapy for XMEN disease. Journal of Allergy and Clinical Immunology.2023 Jun, 151(6):1622-1633.e10.  (*: corresponding)

4.Jiang X, Wang J, Zheng X, Liu Z, Zhang X, Li Y,  Wilhelm J, Sumer BD, Lea L, Lu Z*, Gao J*, Luo M*. Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy. Journal For Immunotherapy of Cancer, 2022 May, http://dx.doi.org /10.1136/jitc-2021-003960.(*: corresponding)

5.Gu Y, Cao J, Zhang X, Gao H, Wang Y, Wang J, Jiang X, Zhang J, Shen G, Yang J, Zheng X, Xu J, Lan F, Qu D, Zhao Y, Xu G, Xie Y*, Luo M*, Lu Z* . Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell Res, 2022 Jan;32(1):24-37. (*: corresponding)

6.Li S, Luo M, Wang Z, Fu YXBaran S, Yu H , Gao J. Prolonged activation of innate immune pathways by a polyvalent STING agonist. Nature Biomedical Engineering. 2021 May; 5(5):455-466.

7.Yin WM, Li YW, Gu YQ, Luo M*. Nanoengineered targeting strategy for cancer immunotherapy. Acta Pharmacol Sin. 2020 Jul;41(7):902-910. (*: corresponding)

8.Miller J, Luo M, ChenZJ, Gao J, Zhao T. ONM-500  a novel STING-activating therapeutic nanovaccine platform for cancer immunotherapy. Journal For Immunotherapy of Cancer, 2020 April; 8(A7-A8).

9.Luo M, Liu ZD, Fu Yang-Xin, Gao Jinming. Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy, Journal of Controlled Release, 2019, 300154-160.

10.Luo M., Wang H., Wang Z., Cai H., Lu Z., Huang G., Chen X., Porembka M., Frankel A, Zhijian J. Chen, Gao J. A STING-activating nanovaccine for cancer immunotherapy. Nat Nanotechnoloty. 12(7):648-654, 2017.

11.Luo M, Layla Z. Samandi, Zhaohui Wang, Zhijian J. Chen and Jinming Gao, Synthetic nanovaccines for T cell immunotherapy, Journal of Control Release. 263:200-210, 2017, (Invited review)

12.Wang Z.*, Luo M.*, Mao C., Wei Q., Zhao T., Li Y., Huang G., and Gao J. A Redox Activatable Fluorescent Sensor for the High-Throughput Quantification of Cytosolic Delivery of Macromolecules. Angew. Chem. 2017. 129:1339-1343.

13.Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC. Fasting selectively blocks acute lymphoblastic leukemia development via leptin receptor upregulation. Nature Medicine. 2017. 23(1): 79-90.

14.Zhao T., Huang G., Li Y., Yang S., Ramezani S., Lin Z., Wang Y., Ma X., Zeng Z., Luo M., Boer E., Xie X., Thibodeaux J., Brekken RA, Sun X., Sumer BD, Gao J. A transistor-like pH nanoprobe for tumor detection and image-guided surgery. Nature Biomed. Eng. 2016, DOI: 10.1038/s41551-016-0006.

 


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