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王璞

发表时间:2022-02-11  |  阅读次数:12110次  |  字体大小 [ ]
  • 王璞

    博士,副研究员
    地址:上海市东安路131号,上海 200032
    邮箱:wangpu@fudan.edu.cn

工作经历
副研究员(2025.7至今)
青年副研究员(2019.11-2025.6)
教育经历
博士,复旦大学(2008.9-2013.6)
学士,浙江大学(2004.9-2008.6)
研究方向
致力于细胞间通讯的研究:鉴定新的细胞间通讯的信号配体和信号受体,在分子、细胞和动物体层面研究代谢物等信号分子的生物学功能。以第一作者或通讯作者在Journal of Clinical Investigation, Journal of Hepatology, Cell Reports, Oncogene等杂志上发表过研究论文。主持国自然面上等项目。
代表论文

1.Zeng YR#, Song JB#, Wang D, Huang ZX, Zhang C, Sun YP, Shu G, Xiong Y, Guan KL, Ye D*, Wang P*.The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response. J Clin Invest. 2023 Mar 15;133(6):e160463. doi: 10.1172/JCI160463.

2.Sun R, Zhang Z, Bao R, Guo X, Gu Y, Yang W, Wei J, Chen X, Tong L, Meng J, Zhong C, Zhang C, Zhang J, Sun Y, Ling C, Tong X, Yu FX, Yu H, Qu W, Zhao B, Guo W, Qian M, Saiyin H, Liu Y, Liu RH, Xie C, Liu W, Xiong Y, Guan KL, Shi Y*, Wang P*, Ye D*. Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis. J Hepatol. 2022 Aug;77(2):453-466

3.Wang P., Yan F., Li Z., Yu Y., Parnell S., Xiong Y. (2019) Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. J Clin Invest 130:4393-4407

4.Wang P., Wu J., Ma S., Zhang L., Yao J., Hoadley KA., Wilkerson MD., Perou CM., Guan KL., Ye D., Xiong Y. (2015) Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Reports 22;13(11):2353-61

5.Wang, P., Dong, QZ., Zhang, C., Kuan, PF., Liu, YF., Jeck, WR., Jiang, WQ., Savich, GL., Tan, TX., Andersen, JB., J. Auman, JY., Hoskins, JM., Misher, AD., Moser, CD., Yourstone, SM.,  Kim, JW., Cibulskis, K., Getz, G., Hunt, HV., Thorgeirsson, SS., Roberts, LR.,  Ye, D., Guan, K-L., Xiong, Y. , Qin, L-X. , Chiang, DY. (2013)  Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas . Oncogene 32(25):3091-100

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