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梁琳慧

发表时间:2022-02-11  |  阅读次数:12045次  |  字体大小 [ ]
  • 梁琳慧

    博士,复旦大学研究员,博士生导师
    地址:东安路270号,上海 200032
    邮箱:lianglinhui@fudan.edu.cn

工作经历
研究员,复旦大学,生物医学研究院及复旦附属肿瘤医院 (2022.01-今)
副研究员,复旦大学,生物医学研究院及复旦附属肿瘤医院 (2013.09-2021.12)
副研究员,上海市肿瘤研究所,癌基因及相关基因国家重点实验室 (2011.01-2013.08)
助理研究员,上海市肿瘤研究所,癌基因及相关基因国家重点实验室 (2006.07-2010.12)
教育经历
博士,中国协和医科大学,血液学研究所 (2001.09-2006.07)
学士,吉林大学,生命科学学院 (1997.09-2001.07)
所获人才项目
上海市卫生局新优青人才计划(2013)
上海市青年科技启明星人才计划(2011)
所获奖项
教育部自然科学奖二等奖(2012)
上海医学科技奖二等奖(2011)
研究方向
研究领域为肿瘤分子生物学,主要从事消化系统恶性肿瘤发病的分子机制,聚焦于非编码RNA在肿瘤发生与转移中的功能、作用机制, 以及肿瘤特异表达非编码RNA在肿瘤发生发展、肿瘤靶向治疗、肿瘤免疫中的作用。
招生专业
医学系统生物学
代表论文

1.Wu Y#, Wang J#, Zhao J#, Su Y, Li X, Chen Z, Wu X, Huang S, He X*, Liang L*. LTR retrotransposon-derived LncRNA LINC01446 promotes hepatocellular carcinoma progression and angiogenesis by regulating the SRPK2/SRSF1/VEGF axis. Cancer Lett. 2024 Aug 28:598:217088

2.Linhui Liang#, Lin Huan#, Jiajia Wang#, Yanjun Wu, Shenglin Huang, Xianghuo He. LncRNA RP11-295G20.2 Regulates Cell Growth and Autophagy by Targeting PTEN to Lysosomal Degradation. Cell Discovery, 2021;7(118).

3.Linguo Xu#, Lin Huan#, Tianan Guo, Yangjun Wu, Liu Yanfang, Qifeng Wang, Shenglin Huang, Ye Xu*, Linhui Liang*, Xianghuo He*. LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1a. Oncogene. 2020;39(46):7005-7018.

4.Lin Huan#, Tianan Guo#, Yangjun Wu, Linguo Xu, Shenglin Huang, Ye Xu, *, Linhui Liang,*, Xianghuo He*. Hypoxia induced LUCAT1/PTBP1 Axis Modulates Cancer Cell Viability and Chemotherapy Response. Molecular Cancer. 2020;19(1):11.

5.Yangjun Wu#, Yiming Zhao#, Lin Huan, Jingjing Zhao,Yuqiang Zhou, Linguo Xu, Zhixiang Hu, Yizhe Liu, Zhiao Chen, Lu Wang, Shenglin Huang, Xianghuo He*, Linhui Liang*. A MER52A LTR retrotransposon derived LncRNA promotes HCC metastasis via stabilizing p120-catenin. Cancer Res. 2020;80(5):976-987.

6.Zhou Y#, Huan L#, Wu Y, Bao C, Chen B, Wang L, Huang S, Liang L*, He X*. LncRNA ID2-AS1 suppresses tumor metastasis by activating the HDAC8/ID2 pathway in hepatocellular carcinoma. Cancer Lett. 2020; 469:399-409.

7.Wu Y, Zhou Y, Huan L, Xu L, Shen M, Huang S, Liang L. LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR-10a-5p/NCOR2 axis in hepatocellular carcinoma cells. Cancer Sci. 2019;110(3):973-984

8.Hui Wang#, Linhui Liang#, Qiongzhu Dong#, Lin Huan, Jia He, Botai Li, Chen Yang, Haojie Jin, Lin Wei, Chengtao Yu, Fangyu Zhao, Jinjun Li, Ming Yao, Wenxin Qin*, Lunxiu Qin*, Xianghuo He*. Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma. Theranostics 2018; 8(10): 2814-2829.

9.Huan L, Bao C, Chen D, Li Y, Lian J, Ding J, Huang S, Liang L*, He X*. MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-κB pathway to suppress cell growth in hepatocellular carcinoma cells. Cancer Sci. 2016; 107(3):258-66.

10.Yu Zhang, Jian Yao, Lin Huan, Junwei Lian, Chuanyang Bao, Yan Li, Chao Ge, Jinjun Li, Ming     Yao, Linhui Liang*, Xianghuo He* GNAI3 Inhibits Tumor Cell Migration and Invasion and is Post-transcriptionally regulated by miR-222 in hepatocellular carcinoma. Cancer Lett. 2015356:978-984.

11.Zheng B#, Liang L#, Huang S, Zha R, Liu L, Jia D, Tian Q, Wang Q, Wang C, Long Z, Zhou Y, Cao   X, Du C, Shi Y*, He X*MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers. Oncogene. 2012, 31(42):4509-16.

12.Ying Q#, Liang L#, Guo W, Zha R, Tian Q, Huang S, Yao J, Ding J, Bao M, Ge C, Yao M, Li J, He X*. Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology. 2011, 54(6): 2064-2075.

13.Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X*. MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology. 2010, 52(5): 1731-1740.

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