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曹纬倩

发表时间:2022-02-11  |  阅读次数:12041次  |  字体大小 [ ]
  • 曹纬倩

    博士,副研究员
    地址:上海市东安路131号2号医学科研楼,上海20032
    邮箱: wqcao@fudan.edu.cn

工作经历
副研究员,复旦大学,生物医学研究院(2020.12-至今)
青年副研究员,复旦大学,生物医学研究院(2018.06-2020.11)
助理研究员,复旦大学,生物医学研究院(2017.07-2018.05)
博士后,复旦大学,生物医学研究院(2014.07-2017.06)
教育经历
博士,复旦大学,生物医学研究院(2009.9-2014.6)
学士,苏州大学,生命科学学院(2005.9-2009.6)
所获人才项目
东方英才计划青年项目(2025)
复旦大学卓学优秀人才计划(2025)
招生专业
医学系统生物学
研究方向
本课题组致力于“第三条生命链”——糖质的解码与应用研究。糖质是继核酸与蛋白质后的“第三条生命链”,其解码是揭示生命复杂性的关键。本课题组从方法学、数据科学、生物学到医学应用开展系统研究:1. 方法开发:建立前沿的质谱糖蛋白质组学与糖组学分析方法,为解码提供利器。2. 数据科学:开发AI赋能的质谱数据解析算法与高质量数据库,破解糖质“大数据”解析瓶颈。3. 功能机制:深入探究糖质在生理病理过程中的功能与分子机制。4. 医学转化:挖掘糖质作为癌症等重大疾病的创新诊断标志物,推动临床转化。 近年来,上述方向受到国家自然科学基金委重大研究计划、面上项目、国家重点研发计划等项目的支持,相关工作发表在Nature Methods,Nature Communications,Analytical Chemistry等期刊,并获授权专利6项,软件著作权1项。
代表论文

1.Xie X., Xiang J., Zhao H., Tong B., Zhang L., Kang X., Kong S., Wang T. *, Cao W.*. Integrative quantitative analysis of platelet proteome and site-specific glycoproteome reveals diagnostic potential of platelet glycoproteins for liver cancer, Analytical Chemistry, 2025, 97, 1547.

2.Kong S. #, Wu M. #, Wang X., Zhao H., Zhou X., Yan G., Yao J., Cao W.*. Large-scale glycoproteome analysis reveals inverted distribution of Neu5Gc and Neu5Ac in mouse liver tissues and cell lines, Carbohydrate Polymers, 2025, 367, 123910.

3.Zeng W., Yan G., Zhao H., Liu C., Cao W.*. Uncovering missing glycans and unexpected fragments with pGlycoNovo for site-specific glycosylation analysis across species, Nature Communications, 2024, 15, 8055.

4.Cao W.*. Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis, Current Opinion in Chemical Biology, 2024, 80, 102442.

5.Liu M., Treves G., Amicucci M., Guerrero A., Xu G., Gong T., Davis J., Park D., Galermo A., Wu L., Cao W.*, Lebrilla CB*. GlycoNote with Iterative Decoy Searching and Open-Search Component Analysis for High-Throughput and Reliable Glycan Spectral Interpretation. Analytical Chemistry, 2023, 95, 8223.

6.Kong S.#, Gong P.#, Zeng W.#, Jiang B.#, Hou X., Zhang Y., Zhao H., Liu M., Yan G., Zhou X., Qiao X., Wu M., Yang P., Liu C. *, Cao W.*. pGlycoQuant with a deep residual network for quantitative glycoproteomics at intact glycopeptide level, Nature Communications, 2022, 13, 7539.

7.Zeng W.#,*, Cao W.#, Liu M., He S., Yang P.*. Precise, Fast and Comprehensive Analysis of Intact Glycopeptides and Modified Saccharide Units with pGlyco3,Nature Methods, 2021, 18, 1515.

8.Yang Y.#, Yan G., Kong S., Wu M., Yang P., Cao W.#,*, Qiao L.*. GproDIA enables data-independent acquisition glycoproteomics with comprehensive statistical control, Nature Communications, 2021, 12, 6073.

9.Kong S., Zhang Q., Yang L., Huang Y., Liu M., Yan G., Zhao H., Wu M., Zhang X., Yang P.*, Cao W.*. Effective Enrichment Strategy Using Boronic Acid-Functionalized Mesoporous Graphene–Silica Composites for Intact N- and O-Linked Glycopeptide Analysis in Human Serum, Analytical Chemistry, 2021, 93, 6682.

10.Huang J. #, Wu M. #, Zhang Y., Kong S., Liu M., Jiang B., Yang P.*, Cao W.*.OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation, Genomics, Proteomics & Bioinformatics, 2021, 19, 611.

11.Cao W*, Liu M., Kong S., Wu M., Zhang Y., Yang P*. Recent advances in software tools for more generic and precise intact glycopeptide analysis, Molecular & Cellular Proteomics, 2021, 20, 100060.

12.Huang J., Jiang B, Zhao H., Wu M., Kong S., Liu M., Yang P.*, Cao W.*, Development of a Computational Tool for Automated Interpretation of Intact O-Glycopeptide Tandem Mass Spectra from Single Proteins, Analytical Chemistry, 2020, 92, 6777.

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