张治华

师资队伍

科研人员

首页师资队伍科研人员

张治华

发表时间：2022-02-11　　|　　阅读次数：12041次　　|　　字体大小 [ 小中大 ]

张治华
博士，复旦大学生物医学研究院副研究员, 硕士生导师
地址：上海市东安路131号科研二号楼A3-029
邮箱：zhihuazhang_@fudan.edu.cn

工作经历

2023-至今,复旦大学, 生物医学研究院, 副研究员
2021-2023, 复旦大学, 生物医学研究院, 青年副研究员
2019-2021, 复旦大学, 基础医学流动站, 博士后

教育经历

2016-2019, 复旦大学, 生物化学与分子生物学, 博士

所获奖项

张丽珠生殖医学青年创新奖优秀奖(2023)
谈家桢博士后学者奖（2020）
上海市“超级博士后”激励计划资助(2019)
复旦大学优秀毕业生(2019)

研究方向

人卵母细胞发育与质量调控机制。从遗传学和发育生物学的角度关注并解析卵母细胞生长、成熟以及早期胚胎发育进程中的重要事件以及关键调控因素。近年来围绕人类卵子成熟障碍、受精失败及卵子死亡的遗传学进行了系列研究，研究成果发表于Cell Res，Sci Transl Med，Proc Natl Acad Sci U S A，Am J Hum Genet，Sci Bull，EMBO Rep，Hum Reprod 等国际期刊。

代表论文

(1) Zhang, Z^#., T. Wu^#, Q. Sang*. and L. Wang*. (2025). Human oocyte quality and reproductive health. Sci Bull (Beijing)70(14): 2365-2376 (review).

(2) Zhang, Z*^#., R. Liu^#, H. Zhou, Y^#. Luo, J. Mu, J. Fu, T. Wu, B. Chen, Q. Sang* and L. Wang* (2023). YBX2-dependent stabilization of oocyte mRNA through a reversible sponge-like cortical partition. Cell Res33(8): 640-643.

(3) Zhang, Z*^#., R. Yu^#, Q. Shi^#, Z. J. Wu^#, Q. Li^#, J. Mu^#, B. Chen, J. Shi, R. Ni, L. Wu, Q. Li, J. Fu, R. Li, X. Sun, J. Wang, L. He, Y. Kuang*, Q. Sang* and L. Wang* (2024). COX15 deficiency causes oocyte ferroptosis. Proc Natl Acad Sci U S A121(45): e2406174121.

(4) Zhang, Z^#., B. Li, J. Fu^#, R. Li^#, F. Diao^#, C. Li^#, B. Chen, J. Du, Z. Zhou, J. Mu, Z. Yan, L. Wu, S. Liu, W. Wang, L. Zhao, J. Dong, L. He, X. Liang, Y. Kuang, X. Sun, Q. Sang* and L. Wang* (2020). Bi-allelic Missense Pathogenic Variants in TRIP13 Cause Female Infertility Characterized by Oocyte Maturation Arrest. Am J Hum Genet107(1): 15-23.

(5) Sang, Q*^#., Z. Zhang^#, J. Shi^#, X. Sun^#, B. Li^#, Z. Yan^#, S. Xue, A. Ai, Q. Lyu, W. Li, J. Zhang, L. Wu, X. Mao, B. Chen, J. Mu, Q. Li, J. Du, Q. Sun, L. Jin, L. He, S. Zhu, Y. Kuang* and L. Wang*(2019). A pannexin 1 channelopathy causes human oocyte death. Sci Transl Med11(485).

(6) Chen B^#, Zhang Z^#, Sun X^#, Kuang Y^#, Mao X^#, Wang X^#, Yan Z, Li B, Xu Y, Yu M, Fu J, Mu J, Zhou Z, Li Q, Jin L, He L, Sang Q*, Wang L*. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2017 Oct 5;101(4):609-615.

(7) Sang Q*, Li B^#, Kuang Y^#, Wang X^#, Zhang Z^#, Chen B^#, Wu L^#, Lyu Q, Fu Y, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Wang L*. Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet. 2018 Apr 5;102(4):649-657.

(8) Fan, H^#., R. Liu, R. Yu, B. Chen, Q. Li, J. Mu, W. Wang, T. Wu, L. He, L. Wang, Q*. Sang*and Z. Zhang*(2025). The E3 ubiquitin ligase adaptor KLHL8 targets ZAR1 to regulate maternal mRNA degradation in oocytes. EMBO Rep26(17): 4364-4387.

(9) Qu, R^#., F. Liang^#, L. Fan^#, R. Shi, Z. Chen, B. Chen, H. Gu, X. Du, T. Wu, H. Fan, R. Yu, Y. Luo, J. Mu, W. Wang, Q. Li, J. Shi, L. Wang, X. Sun, Z. Zhang* and Q. Sang* (2025). Pathogenic variants in DLGAP5 cause female infertility characterized by oocyte maturation arrest and embryonic arrest. Hum Reprod40(9): 1773-1785.

(10) Zhang Z^#, Liu R^#, Zhou H^#, Li Q, Qu R, Wang W, Zhou Z, Yu R, Zeng Y, Mu J, Chen B, Guo X*, Sang Q*, Wang L*. PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1. Development. 2023 Jun 15;150(12):dev201572.