杨慧蓉

博士,副研究员,硕士生导师
地址:东安路131号,明道楼 711室,上海 200032
邮箱:yanghr@fudan.edu.cn
1.Liu, C. #, Ren, Y. #, Luo, X.#, Zhou, P., Du, X., Wang, Q., Han, X., Xu, Y., Wang, P., Zhao, D.*, Yang, H. *. Inhibition of HER2 signaling and breast cancer cell growth with a novel antibody targeting HER2 ECD III/IV. PLOS ONE
2.Zhao, D., Liu, W., Chen, K., Wu, Z., Yang, H. *, and Xu, Y.* (2021) Structure of the human RNA polymerase I elongation complex. Cell Discov 7, 97
3.Yang, H.*, Yu, Z., Chen, X., Li, J., Li, N., Cheng, J., Gao, N., Yuan, H., Ye, D. Guan. K., Xu, Y.* (2021) Structural insights into TSC complex assembly and GAP activity on Rheb.Nat Commun. 12: 339.
4.Chen, X., Liu, M., Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J., Yang, H.*, Xu, Y.*(2018) Cryo-EM structure of human mTOR complex 2. Cell research28, 518-528
5.Yang H, Chen X, Liu M, Xu, Y.* (2018) The structure of mTOR complexes at a glance. Precis Cancer Med1:7
6.Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M. Q., Wong, C. C., Wang, J., Xu, Y.*, and Wang, H. W*. (2016) 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1. Protein & cell 7, 878-887
7.Fang J, Cheng J, Wang J, Zhang Q, Liu M, Gong R, Wang P, Zhang X, Feng Y, Lan W, Wong J, Yang H*, Cao C*, Xu, Y.* (2016) Hemi-methylated DNA Opens a Closed Conformation of UHRF1 to Facilitate Its Histone Recognition. Nat Commun. 7:11197.
8.Cheng J, Li Z, Gong R, Fang J, Yang Y, Sun C, Yang H, Xu Y.* (2015)Molecular mechanism for the substrate recognition of USP7. Protein Cell. Nov;6(11):849-52.
9.Cheng J#, Yang H#, Fang J, Ma L, Gong R, Wang P, Li Z, Xu Y.* (2015) Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun. 6:7023
10.Yang Y, Yin X, Yang H, Xu, Y.* (2015) Histone Demethylase LSD2 Acts as an E3 Ubiquitin Ligase and Inhibits Cancer Cell Growth through Promoting Proteasomal Degradation of OGT. Molecular cell 58, 47-59
11.Zhang, Y#., Yang, H#., Guo, X#., Rong, N., Song, Y., Xu, Y., Lan, W., Zhang, X., Liu, M., Xu, Y.*, and Cao, C.* (2014) The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein & cell 5, 837-850
12.Zhang, Z.,Yang, H.,Wang, H*. (2014) The histone H2A Yang, Huirong deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage. J Biol Chem,11.21,289(47):32883~32894
13.Yang, H. #, Gong, R. #, and Xu, Y.* (2013) Control of cell growth: Rag GTPases in activation of TORC1, Cellular and molecular life sciences : CMLS70, 2873-2885.
14.Xu, Y. #, Yang, H. #, Joo, HY. #, Yu JH, Smith AD IV, Schneider D, Chow LT, Renfrow M, Wang H#.(2013) Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression. Cell Cycle. 12(19):3219-27.
15.Chen, F. #, Yang, H. #, Dong, Z. #, Fang, J., Wang, P., Zhu, T., Gong, W., Fang, R., Shi, Y. G., Li, Z.*, and Xu, Y.* (2013) Structural insight into substrate recognition by histone demethylase LSD2/KDM1b, Cell research23, 306-309.
16.Gong, R. #, Li, L. #, Liu, Y. #, Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K. L., and Xu, Y.* (2011) Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation, Genes & development25, 1668-1673.
17.Guo, X.#, Xu, Y. #, Wang, P., Li, Z., Xu, Y.*, and Yang, H.*(2011) Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B, Acta crystallographica67, 907-910.
18.Yang, H. #, Wang, Z. #, Shen, Y.#, Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D.*, Murchie, A. I.*, and Xu, Y.* (2010) Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus, Biochemistry 49, 6440-6450.
19.Yang, H.#, Wang, P.#, Dong, Z.#, Li, X., Gong, R., Yang, Y., Li, Z., Xu, Y., and Xu, Y.* (2010) Crystallization and preliminary crystallographic analysis of nosiheptide-resistance methyltransferase from Streptomyces actuosus in complex with SAM, Acta crystallographica 66, 579-582.
20.Lin, Y.#, Wang, P.#, Yang, H.*, and Xu, Y.* (2010) Crystallization and preliminary crystallographic analysis of the ADP-ribosyltransferase HopU1, Acta crystallographica 66, 932-934.