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杨慧蓉

发表时间:2022-02-11  |  阅读次数:16102次  |  字体大小 [ ]
  • 杨慧蓉

    博士,副研究员,硕士生导师
    地址:东安路131号,明道楼 711室,上海 200032
    邮箱:yanghr@fudan.edu.cn

工作经历
复旦大学生物医学研究院,副研究员(2013.12-今)
阿拉巴马伯明翰大学,访问学者(2011.01-2012.01)
复旦大学生物医学研究院,助理研究员(2008.01-2013.11)
教育经历
复旦大学,生命科学学院,遗传工程国家重点实验室,博士 (2002.09-2008.01)
山西医科大学,药学院,学士 (1998.09-2002.077)
所获人才项目
国家自然基金面上 2022
国家自然基金面上 2018
上海市自然基金 2021
复旦大学卓学人才 2015
浦江人才计划 2013
国家自然基金青年 2012
研究方向
研究与细胞生长、增值调控相关的蛋白质复合体的结构和功能。研究对象包括与肿瘤密切相关的mTOR信号通路的蛋白质复合体;RNA转录相关蛋白复合体;表观遗传领域重要的甲基化修饰酶复合体。近年来总共发表论文20余篇,以第一作者以及共同通讯发表在Nature Communications(3篇),Cell Res,Cell Discovery,Protein & Cell (2篇)等期刊。多项研究成果得到了国际专业文献评估系统“Faculty of 1000”的评价,认为是New Findings。
代表论文

1.Liu, C. #, Ren, Y. #, Luo, X.#,  Zhou, P., Du, X., Wang, Q., Han, X., Xu, Y., Wang, P., Zhao, D.*, Yang, H. *. Inhibition of HER2 signaling and breast cancer cell growth with a novel antibody targeting HER2 ECD III/IV. PLOS ONE

2.Zhao, D., Liu, W., Chen, K., Wu, Z., Yang, H. *, and Xu, Y.* (2021) Structure of the human RNA polymerase I elongation complex. Cell Discov 7, 97

3.Yang, H.*, Yu, Z., Chen, X., Li, J., Li, N., Cheng, J., Gao, N., Yuan, H., Ye, D. Guan. K., Xu, Y.* (2021) Structural insights into TSC complex assembly and GAP activity on Rheb.Nat Commun. 12: 339.

4.Chen, X., Liu, M., Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J., Yang, H.*, Xu, Y.*(2018) Cryo-EM structure of human mTOR complex 2. Cell research28, 518-528

5.Yang H, Chen X, Liu M, Xu, Y.* (2018) The structure of mTOR complexes at a glance. Precis Cancer Med1:7

6.Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M. Q., Wong, C. C., Wang, J., Xu, Y.*, and Wang, H. W*. (2016) 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1. Protein & cell 7, 878-887

7.Fang J, Cheng J, Wang J, Zhang Q, Liu M, Gong R, Wang P, Zhang X, Feng Y, Lan W, Wong J, Yang H*, Cao C*, Xu, Y.* (2016) Hemi-methylated DNA Opens a Closed Conformation of UHRF1 to Facilitate Its Histone Recognition. Nat Commun. 7:11197.

8.Cheng J, Li Z, Gong R, Fang J, Yang Y, Sun C, Yang H, Xu Y.* (2015)Molecular mechanism for the substrate recognition of USP7. Protein Cell. Nov;6(11):849-52.

9.Cheng J#, Yang H#, Fang J, Ma L, Gong R, Wang P, Li Z, Xu Y.* (2015) Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun. 6:7023

10.Yang Y, Yin X, Yang H, Xu, Y.* (2015) Histone Demethylase LSD2 Acts as an E3 Ubiquitin Ligase and Inhibits Cancer Cell Growth through Promoting Proteasomal Degradation of OGT. Molecular cell 58, 47-59

11.Zhang, Y#., Yang, H#., Guo, X#., Rong, N., Song, Y., Xu, Y., Lan, W., Zhang, X., Liu, M., Xu, Y.*, and Cao, C.* (2014) The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein & cell 5, 837-850

12.Zhang, Z.Yang, H.Wang, H*. (2014) The histone H2A Yang, Huirong deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage. J Biol Chem11.2128947):32883~32894

13.Yang, H. #, Gong, R. #, and Xu, Y.* (2013) Control of cell growth: Rag GTPases in activation of TORC1, Cellular and molecular life sciences : CMLS70, 2873-2885.

14.Xu, Y. #, Yang, H. #, Joo, HY. #, Yu JH, Smith AD IV, Schneider D, Chow LT, Renfrow M, Wang H#.(2013)  Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression. Cell Cycle. 12(19):3219-27.

15.Chen, F. #, Yang, H. #, Dong, Z. #, Fang, J., Wang, P., Zhu, T., Gong, W., Fang, R., Shi, Y. G., Li, Z.*, and Xu, Y.* (2013) Structural insight into substrate recognition by histone demethylase LSD2/KDM1b, Cell research23, 306-309.

16.Gong, R. #, Li, L. #, Liu, Y. #, Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K. L., and Xu, Y.* (2011) Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation, Genes & development25, 1668-1673.

17.Guo, X.#, Xu, Y. #, Wang, P., Li, Z., Xu, Y.*, and Yang, H.*(2011) Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B, Acta crystallographica67, 907-910.

18.Yang, H. #, Wang, Z. #, Shen, Y.#, Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D.*,  Murchie, A. I.*, and Xu, Y.* (2010) Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus, Biochemistry 49, 6440-6450.

19.Yang, H.#, Wang, P.#, Dong, Z.#, Li, X., Gong, R., Yang, Y., Li, Z., Xu, Y., and Xu, Y.* (2010) Crystallization and preliminary crystallographic analysis of nosiheptide-resistance methyltransferase from Streptomyces actuosus in complex with SAM, Acta crystallographica 66, 579-582.

20.Lin, Y.#, Wang, P.#, Yang, H.*, and Xu, Y.* (2010) Crystallization and preliminary crystallographic analysis of the ADP-ribosyltransferase HopU1, Acta crystallographica 66, 932-934.

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