博士,研究员,博士生导师
地址:东安路 131号,明道楼 504 室,上海 200032
电话:021-54237874(办公室),021-54237821(实验室)
邮箱:fei_lan@fudan.edu.cn
多能干细胞Naïve与Premed状态的表观遗传调控机制研究获批“干细胞及转化研究试点”专项(青年科学家项目)首席,获批经费:589万
Wan, J., Xing, S., Ding, L., Wang, Y., Gu, C., Wu, Y., Rong, B., Li, C., Wang, S., Chen, K., He, C., Zhu, D., Yuan, S., Qiu, C., Zhao, C., Nie, L., Gao, Z., Jiao, J., Zhang, X., Wang, X., Ying, T., Wang, H., Xie, Y.*, Lu, Y.*, Xu, J.*, and Lan, F.* (2020) Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection. Cell Reports 32, 107918-107918(* Correspondence)
Yao Chen, Ruitu Lv, Bowen Rong, Yuxuan Zheng, Zhen Lin, Ruofei Dai, Xi Zhang, Nannan Xie, Siqing Wang, Fuchou Tang*, Fei Lan* and Ming-Han Tong* (2020) Refined Spatial-temporal Epigenomic Profiling Reveals Intrinsic Connection between PRDM9-mediated H3K4me3 and the Fate of Double-stranded Breaks. Cell Research,2020(* Correspondence)
Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen*, Feizhen Wu*, Fei Lan* (2019) DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation. Protein & Cell, 2019, Nov 22 Early online, PMID 31758527(* Correspondence)
Jianqing Wang*, Chenxi He, Peng Gao, Siqing Wang, Ruitu Lv, Huihui Zhou, Qidong Zhou, Ke Zhang, Jian Sun, Caibin Fan, Guanxiong Ding* and Fei Lan* (2019) HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer. Oncogene, 2019, Oct 21 Early Online, PMID 31636385(* Correspondence)
Zhennan Shi, Siyuan Xu, Shenghui Xing, Ke Yao, Lei Zhang, Luxi Xue, Bisi Miao, Peng Zhou, Ming Wang, Guoquan Yan, Pengyuan Yang, Jing Liu, Zeping Hu*, Fei Lan*(2019)Mettl17, a Regulator of Mitochondrial Ribosomal RNA Modifications, Is Required for the Translation of Mitochondrial Coding Genes. FASEB J., 2019, Nov., 33(11), 13040-13050(* Correspondence)
Zhao B, Xu W, Rong B, Chen G, Ye X, Dai R, Li W, Chen J, Cai J, Song L, Luo ZQ, Zeng R, Shi Y, Han JJ, Lan F*. H3K14me3 Genomic Distributions and its regulation by KDM4 family demethylases. Cell Research. 2018 Nov;28(11):1118-1120. Epub 2018 Oct 18. (* Correspondence)
8.Zuo X, Rong B, Li L, Lv R, Lan F*, Tong MH*. The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. J. Boil. Chem. 2018 Jun 15;293(24):9188-9197. Epub 2018 May 1.(* Correspondence)
Shen H, Xu W, Lan F*. Histone lysine demethylases in mammalian embryonic development. (Review) Exp Mol Med. 2017 Apr 28;49(4):e325. (* Correspondence)
Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F*, Shi Y*. Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency. Cell Rep. 2016 Oct 18;17(4):997-1007. (* Correspondence)
Shen H, Xu W, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Shao Z-M, Yang PY, Wu FZ, Shi YG, Shi Y*, Lan F*. Suppression of Enhancer Over-activation by a RACK7-Histone Demethylase Complex. Cell. 2016 Apr 7;165(2):331-42. (* Correspondence)
Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F*, He QY*, Zhang G*, Wang T*. Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria. J Proteome Res. 2015 Sep 4;14(9):3645-57. (* Correspondence)
Lan F*, Shi Y*. Histone H3.3 and Cancer: a potential reader connection. (Review) Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6814-9. (* Correspondence)
Guo R, Zheng LJ, Park JW, Xu WQ, Chen H, Qiu JS, Lv RT, Wang ZT, Yang PY, Wu FZ, Shi XB, Fu XD, Shi X, Shi YG, Xing Y*, Lan F*, Shi Y*. BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing. Mol Cell. 2014 Oct 23;56(2):298-310. (* Correspondence)
Lan F*, Nottke AC*, Shi Y. Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol. 2008 Jun;20(3):316-25. Epub 2008 Apr 25. (* Co-first)
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.A histone H3 lysine 27 demethylase regulates animal posterior development. Nature Article. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12.
Lan F*, Collins RE*, De Cegli R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Shi Y. Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature. 2007 Aug 9;448(7154):718-22. (* Co-first)
Lan F, Zaratiegui M, Villén J, Vaughn MW, Verdel A, Huarte M, Shi Y, Gygi SP, Moazed D, Martienssen RA, Shi Y. S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol Cell. 2007 Apr 13;26(1):89-101.
Iwase S*, Lan F*, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23;128(6):1077-88. Epub 2007 Feb 22. (* Co-first)
Shi YJ, Matson C*, Lan F*, Iwase S, Baba T, Shi Y. Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 2005 Sep 16;19(6):857-64. (* Co-second)
Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004 Dec 29;119(7):941-53