Education

Ph.D., Chemistry, Columbia University Aug. 2014 – Dec. 2019

B.S., Chemistry, Peking University Sept. 2010 – July 2014

Work experience

Associate Professor, Fudan University Shanghai Medical College Nov. 2022-now

Postdoctoral Research Scientist, Columbia University Jan. 2020-Aug. 2022

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032

Email: shilixue@fudan.edu.cn

Biography

Lixue Shi is an associate professor of the Institutes of Biomedical Sciences (IBS) at Fudan University. Lixue received her B.S. degree in Chemistry from Peking University in 2014 and Ph.D. degree in Physical Chemistry from Columbia University in 2019. Lixue then stayed at Columbia and completed her postdoctoral training in 2022. Shi Lab focuses on the purpose-driven development of vibrational imaging tools and their applications in pathology and clinical medicine.

Research Areas

Bio-imaging, vibrational spectroscopy and microscopy

Research interest

Our lab focuses on developing next-generation vibrational imaging tools and devising their applications in pathology and clinical medicine. We integrated spectroscopic developments with chemical innovations (vibrational probes, sensors, tissue sample engineering, etc) to deliver new biophysical methodologies, deciphering biological complexity under 3D spatial context.

Selected Publications

L. Shi⁺, M. Wei⁺, Y. Miao, N. Qian, L. Shi, R. Singer, R. Benninger, W. Min*, Highly-multiplexed volumetric mapping with Raman dye imaging and tissue clearing, Nat. Biotechnol., 40, 264-373, (2022). ⁺equal contribution

L. Shi, A. Klimas, B. Gallagher, Z. Cheng, F. Fu, P. Wijesekara, Y. Miao, X. Ren, Y. Zhao*, W. Min*, Super-resolution vibrational imaging using expansion stimulated Raman scattering microscopy, Adv. Sci. 2200315, (2022).

L. Shi, X. Liu, L. Shi, H. T. Stinson, J. Rowlette, L. J. Kahl, C. R. Evans, C. Zheng, L. E. P. Dietrich, W. Min*, Mid-infrared metabolic imaging with vibrational probes, Nat. Methods, 17, 844-851, (2020).

L. Shi, F. Hu, W. Min*, Optically mapping of biological water in single live cells by stimulated Raman excited fluorescence microscopy, Nat. Commun. 10 (1), 1-8, (2019).

F. Hu⁺, L. Shi⁺, W. Min*, Biological imaging of chemical bonds by stimulated Raman scattering microscopy, Nat. Methods, 16, 830-842, (2019). ⁺equal contribution

H. Xiong⁺, L. Shi⁺, L. Wei, Y. Shen, R. Long, Z. Zhao, W. Min*, Stimulated Raman excited fluorescence spectroscopy and imaging, Nat. Photonics., 13, 412-417 (2019). ⁺equal contribution

L. Wei, Z. Chen, L. Shi, R. Long, A. V. Anzalone, L. Zhang, F. Hu, R. Yuste, V. W. Cornish and W. Min*, Super-multiplex vibrational imaging, Nature, 544, 465-470 (2017).