Wang Gangqi
Gangqi Wang, Ph.D.
➢ PhD Leiden University, The Netherlands (2014-2020)
➢ MSc Jilin University (2011-2014)
➢ BA Herbin Insititute of Technology (2007-2011)
➢ Associate Professor Fudan University (2024.5-)
➢ Postdoc Researcher Leiden University Medical Center, The Netherlands (2020-2024)
Our research team is dedicated to investigating the regulatory mechanisms of cell metabolism in cell fate decision during kidney development and regeneration. Our work encompasses the development of spatial metabolomics technology, as well as research into kidney development, organ differentiation, acute kidney injury, ex vivo kidney perfusion, diabetic kidney disease, and endothelial glycocalyx function. We have developed spatial quantitative metabolomics and spatial dynamic metabolomics platforms. Alongside other spatial technologies such as spatial transcriptomics and spatial ATACseq, we've established a multi-omics pipeline that connects the metabolome, epigenome, and transcriptome.
1.Marlon JA de Haan, Franca MR Witjas, Annemarie MA de Graaf, Marleen E Jacobs, Elena Sanchez-Lopez, Sarantos Kostidis, Martin A Giera, Mehdi Maanaoui, Thomas Hubert, Julie Kerr-Conte, Francois Pattou, Dorottya K de Vries, Jesper Kers, Ian PJ Alwayn, Cees van Kooten, Bram PAM Heijs, Gangqi Wang*, Marten A Engelse*, Ton J Rabelink*. Advancing multi-day ex vivo kidney perfusion using spatially resolved metabolomics. Nature Communications, 2024 (accepted）
2.Gangqi Wang, Bram Heijs, Sarantos Kostidis, Rosalie GJ Rietjens, Marije Koning, Lushun Yuan, Gesa L Tiemeier, Ahmed Mahfouz, Sebastien J Dumas, Martin Giera, Jesper Kers, Susana M Chuva de Sousa Lopes, Cathelijne W van den Berg, Bernard M van den Berg, Ton J Rabelink. Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation. Cell Stem Cell, 2022, 29.11: 1580-1593. e7.
3.Gangqi Wang, Bram Heijs, Sarantos Kostidis, Ahmed Mahfouz, Rosalie GJ Rietjens, Roel Bijkerk, Angela Koudijs, Loïs AK van der Pluijm, Cathelijne W van den Berg, Sébastien J Dumas, Peter Carmeliet, Martin Giera, Bernard M van den Berg, Ton J Rabelink. Analyzing cell-type-specific dynamics of metabolism in kidney repair. Nature Metabolism, 2022, 4.9: 1109-1118.
4.Gangqi Wang, Gesa L Tiemeier, Bernard M van den Berg, Ton J Rabelink. Endothelial glycocalyx hyaluronan: regulation and role in prevention of diabetic complications. The American journal of pathology, 2020, 190.4: 781-790.
5.Gangqi Wang, Sarantos Kostidis, Gesa L Tiemeier, Wendy MPJ Sol, Margreet R de Vries, Martin Giera, Peter Carmeliet, Bernard M van den Berg, Ton J Rabelink. Shear stress regulation of endothelial glycocalyx structure is determined by glucobiosynthesis. Arteriosclerosis, thrombosis, and vascular biology, 2020, 40.2: 350-364.
6.Gangqi Wang, Margreet R de Vries, Wendy MPJ Sol, Annemarie M van Oeveren-Rietdijk, Hetty C de Boer, Anton Jan van Zonneveld, Paul HA Quax, Ton J Rabelink, Bernard M van den Berg. Loss of endothelial glycocalyx hyaluronan impairs endothelial stability and adaptive vascular remodeling after arterial ischemia. Cells, 2020, 9.4: 824.
7.Bernard M Van Den Berg*, Gangqi Wang*, Margien GS Boels, M Cristina Avramut, Erik Jansen, Wendy MPJ Sol, Franck Lebrin, Anton Jan Van Zonneveld, Eelco JP De Koning, Hans Vink, Hermann-Josef Gröne, Peter Carmeliet, Johan Van Der Vlag, Ton J Rabelink. Glomerular function and structural integrity depend on hyaluronan synthesis by glomerular endothelium. Journal of the American Society of Nephrology, 2019, 30.10: 1886-1897.
