Education

➢ Ph.D Institute of Biophysics, Chinese Academy of Sciences (2009-2012)

➢ Ms.D Institute of Biophysics, Chinese Academy of Sciences (2006-2009)

➢ B.S. College of Life Sciences, Wuhan University (2002-2006)

Work experience

➢ PI, Fudan University, School of Stomatology & Shanghai Stomatological Hospital (2020.12~present)

➢ PI, Fudan University, Institutes of Biomedical Sciences (2020.09~present)

➢ Research Scientist, Stanford University (2017.06~2020.08)

➢ Postdoc, Michigan University (2016.01~2017.05)

➢ Postdoc, UT Southwestern Medical Center (2012.09~2016.01)

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 18971240215

Email: qqh@fudan.edu.cn

Lab homepage: https://www.x-mol.com/groups/qu_qianhui

Research Areas

➢ Structural and functional analysis of membrane proteins

Research interest

How do cells perceive and respond to extracellular stimuli? In humans, the biggest group of cellular membrane proteins (G-protein coupled receptors) and the second biggest group solute carrier family (SLC family) membrane proteins are involved in recognition of numerous signals with diverse identities and initiate distinct signaling cascades. Different epigenetic molecular machineries within nucleus react to these conveyed signals and regulate gene transcription correspondingly. Such cooperation plays essential roles in normal physiology and human diseases. A combination of structural biology (cryo-EM/X-ray crystallography), biochemistry and molecular biology, and computer assisted molecular dynamics simulations have led to our recent progresses (Selected Publications). In future, our interests are to decipher mechanisms underlying the cross-talk between membrane receptors and epigenetic regulators.

Selected Publications

1. Shujin Liu^#, Yulin Chao^#, Zixuan Zhou^#, Chuanhui Yang, Zhini Zhu, Yuwei Wang, Qianhui Qu*. Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A. Cell Discovery, 2024

2. Yuwei Wang^#, Pei Zhang^#, Yulin Chao^#, Zhini Zhu^#, Chuanhui Yang^#, Zixuan Zhou^#, Yaohui Li, Yonghui Long, Yuehua Liu, Dianfan Li, Sheng Wang*, Qianhui Qu*. Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines. Cell Research, 2024, 34, 47-57

3. Jingjing Hong^#, Tingting Li^#, Yulin Chao^#, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu*, Dianfan Li*. Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis. Nature Communications, 2024, 15 (1), 8

4. Yidan Xu^#, Tingting Li^#, Zixuan Zhou^#, Jingjing Hong, Yulin Chao, Zhini Zhu, Ying Zhang, Qianhui Qu*, Dianfan Li*. Structures of substrates- and products-bound glycosylphophatidylinositol transamidase illuminate GPI-AP biogenesis. Nature Communications, 2023, 14 (1), 5520

5. Yidan Xu^#, Guowen Jia^#, Tingting Li^#, Zixuan Zhou^#, Yitian Luo, Yulin Chao, Juan Bao, Zhaoming Su*, Qianhui Qu*, Dianfan Li*. Molecular insights into the biogenesis of glycosylphosphatidylinositol anchor proteins. Nature Communications, 2022, 13 (1),2617

6. Qianhui Qu^#, Weijiao Huang^#, Deniz Aydin^#, Joseph M. Paggi^#, Alpay B. Seven^#, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F. DiBerto, Michael J. Robertson, Asuka Inoue, Carl-Mikael Suomivuori, Bryan L. Roth, Susruta Majumdar*, Ron O. Dror*, Brian K. Kobilka*, Georgios Skiniotis*. Insights into distinct signaling profiles of the μOR activated by diverse agonists. Nature Chemical Biology 2023, 19 (4): 423–430

7. Abdelfattah Faouzi^#, Haoqing Wang^#, Saheem A. Zaidi^#, Tao Che^#, Jeffrey F. DiBerto^#, Qianhui Qu^#, Michael J. Robertson, Manish K. Madasu, Amal El Daibani, Balazs R. Varga, Kevin Appourchaux, Tiffany Zhang, Samuel T. Slocum, Shainnel O. Eans, Ream Al-Hasani, Ying Xian Pan, Bryan L. Roth, Jay P. McLaughlin, Georgios Skiniotis*, Vsevolod Katritch*, Brian K. Kobilka* and Susruta Majumdar*. Structure-based design of functionally selective bitopic ligands for the μ-opioid receptor. Nature 2023, 613 (7945): 767–774

8. Haoqing Wang^#, Florian Hetzer^#, Weijiao Huang^#, Qianhui Qu^#, Justin Meyerowitz, Jonas Kaindl, Harald Hübner, Georgios Skiniotis*, Brian K. Kobilka*, Peter Gmeiner*. Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists. Angewandte Chemie International Edition, 2022, 61(26),e202200269

9. Lei Han^#, Qianhui Qu^#, Deniz Aydin^#, Ouliana Panova, Michael J. Robertson, Yan Xu, Ron O. Dror, Georgios Skiniotis*, Liang Feng*. Structure and mechanism of the SGLT family of glucose transporters. Nature, 2022, 601 (7892), 274-279

10. Weijiao Huang^#, Matthieu Masureel^#, Qianhui Qu^#, John Janetzko^#, Asuka Inoue, Khanh Nguyen, Hideaki Kato, Jeffrey Glenn, Michael Robertson, Georgios Skiniotis*, Brian K. Kobilka*. Structure of the Neurotensin Receptor 1 in complex with β-arrestin 1. Nature, 2020, 579:303-308

11. Shoji Maeda^#, Qianhui Qu^#, Michael J. Robertson, Georgios Skiniotis*, Brian K. Kobilka*. Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science, 2019, 364:552-557

12. Qianhui Qu^#, Yohhei Takahashi^#, Yidai Yang, Hongli Hu, Yan Zhang, Joseph S Brunzelle, Jean-François Couture, Ali Shilatifard*, Georgios Skiniotis*. Structure and conformational dynamics of COMPASS histone H3K4 methyltransferase. Cell, 2018, 174 (5), 1117-1126. e12