Education

2009 Ph.D. Genetics, Wuhan University, China
2004 B. S. Biotechnology, Wuhan University, China

Work experience

2022 – present

Professor, Institutes of Biomedical Sciences and Fudan University Shanghai Cancer Center, Fudan University, China

2016/01 – present

Associate Professor, Institutes of Biomedical Sciences and Fudan University Shanghai Cancer Center, Fudan University, China

2015/01 – 2015/12

Research Scientist, Department of Biochemistry and Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, USA

2012/01 – 2014/12

Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, USA

2009/10 – 2011/12

Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, USA

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 38197018

Email: xiangzhou@fudan.edu.cn

Biography

Dr. Xiang Zhou is currently a professor/principal investigator at Shanghai Cancer Center and Institutes of Biomedical Sciences of Fudan University. His research interests mainly focus on TP53 regulation of cancer metabolism and tumor microenvironment. He received the 2016 USCACA–AFCR scholar award and is funded by the National Natural Science Foundation of China. He has more than 50 publications in scientific journals, such as PNAS, Mol Cancer, Cancer Res, Mol Cell, Nat Commun, Elife, Cell Death Differ, Cell Death Dis, Clin Transl Med, Oncogene, JBC, etc.

Research Areas

To elucidate the roles of wild-type and mutant p53s in cancer;
To determine the roles of p53-associated noncoding RNAs in cancer;
To demonstrate mechanisms of nucleolar stress-induced tumor suppression;
To understand interactions between metabolism, inflammation, and regulated cell death.

Selected Publications

Gan Y^#, Deng J^#, Hao Q, Huang Y, Han T, Xu JG, Zhao M, Yao L, Xu Y, Xiong J, Lu H, Wang C, Chen J*, Zhou X*. UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis. Redox Biol. 2023 Jun;62:102705.

Dong H^#, Liao Q^#, Xie B^#, Qiu YA, Peng Z, Deng J, Xiong J, Lu H, Hao Q*, Zhou X*. Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth. Sci China Life Sci. 2023 Aug 11.

Xiong C, Ling H, Hao Q*, Zhou X*. Cuproptosis: p53-regulated metabolic cell death? Cell Death Differ. 2023 Apr;30(4):876-884.

Han T^#, Tong J^#, Wang M, Gan Y, Gao B, Chen J, Liu Y, Hao Q*, Zhou X*. Olaparib Induces RPL5/RPL11-Dependent p53 Activation via Nucleolar Stress. Front Oncol. 2022 Jun 3;12:821366.
Chen Y^#, Hao Q^#*, Wang S^#, Cao M, Huang Y, Weng X, Wang J, Zhang Z, He X, Lu H, Zhou X*. Inactivation of the tumor suppressor p53 by long non-coding RNA RMRP. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2026813118.
Xu F^#, Li J^#, Ni M, Cheng J, Zhao H, Wang S, Zhou X*, Wu X*. FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2. Mol Cancer. 2021 Mar 3;20(1):45.
Hao Q^#, Li J^#, Zhang Q^#, Xu F^#, Xie B, Lu H, Wu X*, Zhou X*. Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma. Clinical and Translational Medicine. 2021 Aug;11(8):e500.
Huang Y^#, Xie B^#, Cao M, Lu H, Wu X, Hao Q*, Zhou X*. LncRNA RNA Component of Mitochondrial RNA-Processing Endoribonuclease Promotes AKT-Dependent Breast Cancer Growth and Migration by Trapping MicroRNA-206. Front Cell Dev Biol. 2021 Sep 21;9:730538.
Hao Q^#, Chen J^#, Liao J, Huang Y, Gan Y, Larisch S, Zeng SX, Lu H*, Zhou X*. p53 induces ARTS to promote mitochondrial apoptosis. Cell Death Dis. 2021 Feb 24;12(2):204.
Wang S^#, Hao Q^#, Li J^#, Chen Y, Lu H, Wu X*, Zhou X*. Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development. Genes & Diseases. 2020 Nov 21 online.
Huang C^#, Hao Q^#, Shi G, Zhou X*, Zhang Y*. BCL7C suppresses ovarian cancer growth by inactivating mutant p53. J Mol Cell Biol. 2021 May 7;13(2):141-150.
Hao Q*, Wang J, Chen Y, Wang S, Cao M, Lu H, Zhou X*. Dual regulation of p53 by the ribosome maturation factor SBDS. Cell Death Dis. 2020 Mar 20;11(3):197.
Chen Y, Hao Q, Wang J, Li J, Huang C, Zhang Y, Wu X, Lu H*, Zhou X*. Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53. Cell Death Dis. 2019 Sep 30;10(10):737.
Zhou X^#*, Hao Q, Lu H. Mutant p53 in cancer therapy-the barrier or the path. J Mol Cell Biol. 2019 Apr 1;11(4):293-305.