Hengyi Jiang, Research associate, Ph.D.

Education

2012 Ph.D., Institute of Biomedical Science, Fudan University, Shanghai, Major: Biochemistry & Molecular biology

2008 M.S., School of Basic Medical Science, Second Military Medical University, Shanghai, Major: Biochemistry & Molecular biology

2005 B.S., School of Public Healthy, Southeast University, Nanjing, Major: Preventative Medicine

Work experience

• 2022-now, Research associate, Institute of Biomedical Science, Fudan University

• 2017-2021, Research assistant, Institute of Biomedical Science, Fudan University

• 2012-2017, Postdoc fellow, Institute of Biomedical Science, Fudan University

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 021-54237577

Email: jhy@fudan.edu.cn

Lab homepage: https://www.easyseq.com

Github: https://github.com/threadtag

Biography

Hengyi Jiang studied preventive medicine at School of Public Health in Southeast University. During that time, he found his interest in biochemistry and after receiving his bachelor’s degree of medicine he went onto study molecular biology in Secondary Medical University on the topic of identifying proteins affected by Aβ protein in Alzheimer’s disease using drosophila model. Then he continued his pursuit of Ph.D. degree in Fudan University and joined Alastair Murchie’s lab with the research topic of identifying and characterizing mitochondrial RNA polymerase in fission yeast. Later on, he worked on RNA methyltransferase, riboswitches and ribozymes. As one of the first joint authors he discovered the first SAM-utilizing ribozyme that catalyze RNA methylation without protein factor and solved the crystal structure with collaborators. As a amateur programmer, Hengyi actively use scripting languages such as Ruby and PHP in his research daily routines. He developed a lab management system and some small bioinformatic tools available on his site. He also developed a local file managing and note-taking tool using Golang. As a application specialist and electronic specialist, he ran and maintained a SPR machine and HPLC machines. In 2022 Hengyi took the position of research associate in IBS and continued his researches on RNAs.

Research Areas

Ribozyme, riboswitches, RNA modifications, RNA biology

Research interest

• Mechanism and structure of methyltransferase ribozymes

• Discovery of new ribozyme

• Ribozyme function in living organisms

• Identifying new RNA modifications

Selected Publications

1. Jiang, Hengyi^#; Gao,Yanqing^#; Zhang, Lei; Gan, Jianghua^*; Chen, Dongrong^*; Murchie, Alastair I H^*; The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences. Nature Catalysis. 2021, 4(10): 872–881.

2. Liu, Getong^#; Jiang, Hengyi; Sun, Wenxia; Zhang, Jun; Chen, Dongrong^*; Murchie, Alastair I H^*; The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni. Nucleic Acids Research. 2021, 49(18): 10573–10588.

3. Yin, Sitao^#; Jiang, Hengyi^#; Chen, Dongrong^*; Murchie, Alastair I H^*; Substrate recognition and modification by the nosiheptide resistance methyltransferase., PLoS One, 2015, 10(4): e0122972-e0122972.

4. Jia, Xu^#; Zhang, Jing^#; Sun, Wenxia; He, Weizhi; Jiang, Hengyi; Chen, Dongrong^*; Murchie, Alastair I. H.^*; Riboswitch Control of Aminoglycoside Antibiotic Resistance, CELL, 2013, 152(1-2): 68-81

5. Jiang, Hengyi^#; Sun, Wenxia^#; Wang, Zhe^#; Zhang, Jing; Chen, Dongrong^*; Murchie, Alastair I H^*; Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe, Nucleic Acids Res, 2011, 39(12): 5119-5130.