Tan Li
Li Tan, M.D.
M.D. in Molecular Medicine, 2009, Fudan University, Shanghai, China
M.S. in Biochemistry, 2005, Fudan University, Shanghai, China
B.S. in Pharmacy, 2000, Fudan University, Shanghai, China
09/2018-present, Associate Professor, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China
01/2014-present, Associate Professor, Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, and Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China
11/2013-05/2015, Visiting Scientist, Department of Biology, University of Rochester, Rochester, NY, U.S.A.
05/2013-10/2015, Visiting Scientist, Division of Endocrinology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, U.S.A.
11/2009-12/2013,Instructor, Lab of Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai, China
07/2006-10/2009, Instructor, Department of Molecular Genetics, Shanghai Medical College of Fudan University, Shanghai, China
07/2000-06/2006, Assistant, Department of Molecular Genetics, Shanghai Medical College of Fudan University, Shanghai, China
Institutes of Biomedical Sciences, Fudan University, Shanghai 200032
Tel: +86 5423 7876
Email: litan@fudan.edu.cn
Epigenetics, Cancer, Aging and longevity
My research interest is to understand the epigenetic mechanisms that control the stability and plasticity of cell identity. Specific research topics include: 1) regulation and function of Ten-Eleven Translocation (TET) family genes; 2) epigenomic stability of naked mole rat cells; 3) epigenetic mechanisms underlying ferroptosis.
Pei Y, Qian Y, Wang H*, and Tan L*. Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy. Front Oncol. 2022, Jan 31; 12:771870.
Zhu X #, Xiong L#, Lyu R#, Shen Y, Liu L, Li S, Argueta C, Tan L*. Regulation of TET2 gene expression and 5mC oxidation in breast cancer cells by estrogen signaling. Biochem Biophys Res Commun.2022 Jan 22;589:240-246.
Xu B, Wang H*, Tan L*. Dysregulated TET Family Genes and Aberrant 5mC Oxidation in Breast Cancer: Causes and Consequences. Cancers.2021,13,6039.
Lyu R#, Zhu X#, Shen Y#, Xiong L#, Liu L, Liu H, Wu F, Argueta C, Tan L*. Tumor suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells. Epigenetics.2021 Oct 30:1-15.
Wang B, Shen Y, Liu T, Tan L*. ERα promotes transcription of tumor suppressor gene ApoA-I by establishing H3K27ac-enriched chromatin microenvironment in breast cancer cells. J Zhejiang Univ Sci B. 2021 Dec 15; 22(12):1034-1044.
Shen Y#, Liu L#, Wang M#, Xu B, Lyu R, Shi YG*, Tan L*. TET2 Inhibits PD-L1 Gene Expression in Breast Cancer Cells through Histone Deacetylation. Cancers. 2021, 13(9), 2207.
Li S#, Feng J#, Wu F#,*, Cai J, Zhang X, Wang H, Fetahu IS, Iwanicki I, Ma D, Hu T, Liu H, Wang B, Shi G*, Tan L*, Shi YG*. TET2 promotes anti-tumor immunity by governing G-MDSCs and CD8+ T-cell numbers. EMBO reports.2020 Oct 5; 21(10): e49425. https://doi.org/10.15252/embr.201949425.
Yan H#, Tan L#, Liu Y#, Huang N, Cang J, Wang H*. Ten-eleven Translocation Methyl-Cytosine Dioxygenase 2 Deficiency Exacerbates Renal Ischemia-Reperfusion Injury. Clinical Epigenetics. 2020 Jul 2;12(1):98. doi: 10.1186/s13148-020-00892-8.
Liu L#, Shen Y#, Zhu X#, Lv R, Li S, Zhang Z, Shi YG*, Tan L*. ERα is a negative regulator of PD-L1 gene transcription in breast cancer. Biochem Biophys Res Commun. 2018 Oct 20;505(1):157-161.
Tan L#, Ke Z#, Tombline G, Macroetta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu N, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A*, Gorbunova V*. Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports. 2017 Nov 14;9(5):1721-1734.
Kong L#, Tan L#, *, Lv R#, Shi Z, Xiong L, Wu F, Rabidou K, Smith M, He C, Zhang L, Qian Y, Ma D, Lan F, Shi Y*, Shi YG*. A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands. Nucleic Acids Res. 2016 Oct 14;44(18):8682-8692.
Tan L#, Xiong L#, Xu W#, Wu F, Huang N, Xu Y, Kong L, Zheng L, Schwartz L, Shi Y, Shi YG*. Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method. Nucleic Acids Res. 2013 Apr;41(7):e84.
Tan L, Shi YG*. Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development. 2012 Jun;139(11):1895-902.
Xu Y#, Wu F#, Tan L#, Kong L, Xiong L, Deng J, Barbera AJ, Zheng L, Zhang H, Huang S, Min J, Nicholson T, Chen T, Xu G, Shi Y, Zhang K, Shi YG*. Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell. 2011 May 20;42(4):451-64.
