He Lin
Lin He, Ph.D.
Professor, Fellow of Chinese Academy of Sciences, Fellow of the World Academy of Sciences for the advancement of science in developing countries
Institutes of Biomedical Sciences, Fudan University, Shanghai 200032
Email: helinhelin3@163.com
M.S., 1983-1986, Southeast University, China
B.S., 1978-1981, Southeast University, China
PI, Professor, 2000-now, Shanghai Jiao Tong University
PI, Professor, 2003-now, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
PI, Professor, 1998-2003, Shanghai Institute of Physiology, Chinese Academy of Sciences
PI, Professor, 1996-1998, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Senior Researcher, 1992-1996, MRC Human Genetics Unit, The University of Edinburgh
Postdoctoral Fellow, 1991-1992, University of Edinburgh, UK
Dr. Lin HE, Neuropsychiatric Geneticist, is Fellow of Chinese Academy of Sciences and Fellow of the World Academy of Sciences for the advancement of science in developing countries. Dr. He earned his PhD in biochemistry from the University of the West of Scotland and conducted postdoctoral training at the University of Edinburgh, UK.
Dr HE is an active geneticist worldwide and has made significant contributions in studies of monogenetic and polygenetic disorders. His team first uncovered the century puzzle in genetic history, or the IHH (Indian Hedgehog) gene causes brachydactyly type A-1, the first recorded example of human disorder with Mendelian autosomal-dominant inheritance, and also discovered a teeth-related novel genetic disorder, or “He-Zhao deficiency”, which was first disease named with Chinese name. In addition, his team has mapped and cloned several other important monogenic genes, and made a great progress in hunting candidate regions and genes of schizophrenia and other mental disorders by GWAS, meta-analyses and others in the past.
Dr HE also works as editor-in-chief of Journal of Bio-X Research, associate-editor-in-chief of Experimental Biology and Medicine, and member of editorial board of dozens of national and international scientific journeys. He has received several important international and national awards and has published over 500 peer reviewed papers.
Psychiatric disorders-based genomics, nutrigenomics, pharmacogenomics, birth defects
Molecular mechanisms underlying genetic disorders, including major monogenic and polygenic diseases of which psychiatric disorders are mainly focused on, nutrigenomics, pharmacogenomics, translational medicine, and DNA computing technology, etc.
2013 The first prize in Shanghai Natural Science Award
2011 Science and Technology Meritorious Worker Award in Shanghai Science and Technology Awards
2010 Tan Jiazhen Life Science Achievement Award
2009 TWAS Prize in Biology
2003 Second Prize of National Natural Science Award
2002 Distinguished professor of Changjiang Scholars
1998 Special government allowances of the State Council
1997 National Science Fund for Distinguished Young Scholars
1. Shi Y#*, Li Z#, Xu Q#, ……, He L*. Common Variants on 8p12 and 1q24.2 Confer Risk of Schizophrenia. Nat Genet. 2011;43(12):1224-7.
2. Chen P#, Pan D#, Fan C, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y *. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nat Nanotechnol. 2011;6(10):639-44.
3. Li R#, Fan W#, Tian G#, Zhu H#, He L#, Cai J#, ……, Wang J*. The sequence and de novo assembly of the giant pandagenome. Nature. 2010; 463(7279):311-7.
4. Gao B#, Hu J#, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L*, Cheah KS, Chan D. A mutation in Ihh that causes digit abnormalities alters its signaling capacity and range. Nature. 2009; 458(7242):1196-200.
5. O'Donovan MC, ……, He L, ……, Owen MJ. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008;40(9):1053-1055.
6. St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P*, He L*. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005; 294(5):557-62.
7. Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L*. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001; 28(4):386-
