Zhou Yufeng
Yufeng Zhou，M.D.，Ph.D.
Education
Work experience
Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
Children’s Hospital of Fudan University, 399 Wanyuan Rd, Minhang, Shanghai 201102, China
Telephone: 86-21-64932907.
E-mail: yfzhou1@fudan.edu.cn；
Yufeng Zhou, M.D. and Ph.D., now is a professor of Children’s Hospital and Institute of Biomedical Sciences (Joint appointment), Fudan University, Shanghai, China. He got his M.D. degree from Weifang Medical College, China in 1997. He got his M.S. and Ph.D. degree in pediatric immunology from Huazhong University of Science and Technology, China in 2000 and 2006. His resident training in Pediatrics was at Shenzhen Children’s Hospital from 2000 to 2003. He worked as a research associate at Duke University from 2006 to 2007. His postdoctoral fellow training in asthma and allergy was at Asthma and Allergy center, Johns Hopkins University from 2007 to 2011. He was appointed as an Instructor in Johns Hopkins University from 2011 to 2015 and Adjunct Assistant Professor from 2015 to 2019. He was appointed as a professor of Children’s Hospital and Institute of Biomedical Sciences, Fudan University, Shanghai, China after 2015. He is the member of American Academy of Allergy, Asthma & Immunology (AAAAI), American Thoracic Society (ATS), American Association of Immunologists (AAI) and Chinese Society of Allergy. He has published more than 80 papers in a number of highly esteemed journals, such as Nature Medicine, Blood, Journal of Allergy and clinical Immunology, Science Advances, STTT, CDD, etc. His research involved in the pathology and treatment of immune disease including asthma and allergic disease, inflammation disease, auto-immune disease, sepsis and infection. Specifically focused on the role of environment, epigenetics and Metabolic reprogramming in immune regulation.
Research Areas：
The pathology and treatment of immune disease including asthma and allergic disease, inflammation disease, auto-immune disease, tumor, sepsis and infection.
Research interest
Non-coding RNA and immune regulation: It is becoming increasingly clear that epigenetic mechanisms play an important role in modulating immune disease. In response to environmental stimuli, three main epigenetic changes can occur during immune system activation, including DNA methylation, histone modifications, and regulation by non-coding RNAs. Non-coding RNAs, including micro RNAs (miRNAs), piwi-interacting RNAs (piRNAs), endogenous small interfering RNAs (siRNAs), long non-coding RNAs (lncRNAs), and Circular RNAs. We conducted genome-wide analysis of ncRNA expression profiles in immune disease and identified novel ncRNAs with biological, mechanistic, and clinical impact on inflammatory diseases.
Aryl hydrocarbon receptor (AhR) and immune regulation: A wealth of evidence links exposure to outdoor and indoor air pollution, especially airborne particulate matter (PM), to the development and exacerbation of asthma. However, the causal relationship and mechanisms have not been fully established The AhR is a unique cellular “chemical sensor” and a ligand-activated transcription factor. Our finding regarding PM-associated polycyclic aromatic hydrocarbons (PAHs) and interactions with the AhR and its influence on immune responses highlight the potential importance of the AhR–PAH axis in the development of allergic and inflammatory diseases.
Metabolic reprogramming and immune regulation: Accumulating evidence indicates that metabolism reprogramming is critically important to immune cell differentiation and manipulate metabolic pathways in immune cells can shape their fate and function. During the immune cells’ differentiation, metabolism can provide immune cells not only energy but also precursors for various biological processes. Some key metabolic reaction such as glycolysis, oxidative phosphorylation and fatty acid oxidation (FAO) are now considered to play important roles in immune cell activation and differentiation. We are interested to find the metabolic changes of the immune disease and find the metabolic targets and small molecular inhibitors or activators of metabolic enzymes to treat the disease.
Selected Publications(#，co-first author; *,co-corresponding author)
1. Han X#, Liu L#, Huang S#, Xiao W#, Gao Y#, Zhou W, Zhang C, Zheng H, Yang L, Xie X, Liang Q, Tu Z, Yu H, Fu J, Wang L, Zhang X, Qian L*, Zhou Y*. RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis. Nature Communications 2023; 14:7328.
2. Hu XL#, Xiao W#, Lei Y, Green A, Lee X, Maradana MR, Gao Y, Xie X, Wang R, Chennell G, Basson MA, Kille P, Maret W, Bewick GA, Zhou Y*, Hogstrand C*. Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrier. Nature Communications 2023; 14:5431.
3. Wei R#, Han X#, Li M, Ji Y, Zhang L, Christodoulou MI, Hameed Aga NJ, Zhang C, Gao R, Liu J, Fu J, Lu G, Xiao X, Liu X, Yang PC, McInnes IB, Sun Y, Gao P, Qin C*, Huang SK*, Zhou Y*, Xu D*. The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARgamma. Cellular and Molecular Immunology2023.Online ahead of print.
4. Ying J#, Zhang C#, Wang Y, Liu T, Yu Z, Wang K, Chen W, Zhou Y*, Lu G*. Sulodexide improves vascular permeability via glycocalyx remodelling in endothelial cells during sepsis. Frontiers in Immunology 2023; 14:1172892.
5. Liu T#, Zhang C#, Ying J, Wang Y, Yan G, Zhou Y*, Lu G*. Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis. Frontiers in Immunology 2023; 14:1134556.
6. Liang Q#, Fu J#, Wang X, Liu L, Xiao W, Gao Y, Yang L, Yu H, Xie X, Tu Z, Huang S, Han X, Qian L*, Zhou Y*. circS100A11 enhances M2a macrophage activation and lung inflammation in children with asthma. Allergy 2023; 78:1459-1472.
7. Liu KY#, Gao Y#, Xiao W#, Fu J#, Huang S, Han X, Hsu SH, Xiao X, Huang SK*, Zhou Y*. Multidimensional analysis of lung lymph nodes in a mouse model of allergic lung inflammation following pm2.5 and indeno[1,2,3-cd]pyrene exposure. Environmental Health Perspectives 2023; 131:37014.
8. Yuan X#., Wang R#., Han B., Sun C., Chen R., Wei H., Chen L., Du H., Li G., Yang Y., Chen X., Cui L., Xu Z., Fu J., Wu J., Gu W., Chen Z., Fang X., Yang H., Su Z., Wu J., Li Q., Zhang M., Zhou Y., Zhang L., Ji G*., Luo F*. Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes. Nature Communications 2022; 13:6356.
9. Yang L#, Fu J#, Han X#, Zhang C#, Xia L, Zhu R, Huang S, Xiao W, Yu H, Gao Y, Liang Q, Li W*, Zhou Y*. Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis. Journal of Allergy and Clinical Immunology. 2022 Jun;149(6):2021-2033
10. Chen LL#, Morcelle C#, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M, Zhu Y, Zhou N, Cheng M, He C, Liu KY, Lu G, Zhang L, Zhang C, Zhang J, Sun Y, Qi T, Lyu Y, Ren ZZ, Tan XM, Yin J, Lan F, Liu Y, Yang H, Qian M, Duan C, Chang X, Zhou Y, Shen L, Baldwin AS, Guan KL, Xiong Y, Ye D*.Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses.Nature Cell Biology. 2022 Mar;24(3):353-363.
11. Qiu Z., Zhu Z., Liu X., Chen B., Yin H., Gu C., Fang X., Zhu R., Yu T., Mi W., Zhou H., Zhou Y., Yao X*., Li W*. A dysregulated sebum-microbial metabolite-IL-33 axis initiates skin inflammation in atopic dermatitis. Journal of Experimental Medicine 2022; 219(10):e20212397
12. Xue P#, Huang S#, Han X#, Zhang C, Yang L, Xiao W, Fu J, Li H*, Zhou Y*. Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2.Cell Death and Differentiation. 2022 Jan;29(1):82-95.
13. Yang L, Xie X, Tu Z, Fu J, Xu D*, Zhou Y*. The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduction and Targeted Therapy. 2021 Jul 7;6(1):255. doi: 10.1038/s41392-021-00679-0.
14. Xia L#, Wang X#, Liu L#, Fu J#, Xiao W, Liang Q, Han X, Huang S, Sun L, Gao Y, Zhang C, Yang L, Wang L, Qian L*, Zhou Y*. lnc-BAZ2B promotes M2 macrophage activation and inflammation in children with asthma through stabilizing BAZ2B pre-mRNA. Journal of Allergy and Clinical Immunology 2021; 147:921-32 e9.
15. Li H#, Li X#, Zheng H, Liu L, Wu Y, Zhou Y, Meng X, Hong J, Cao L, Lu Y, Dong X, Xia M, Ding B, Qian L, Wang L, Zhou W, Gui Y, Kan H, Chen R*, Zhang X*. Ultrafine particulate air pollution and pediatric emergency-department visits for main respiratory diseases in Shanghai, China. Science of the Total Environment 2021; 775:145777.
16. Zhang C#, Han X#, Yang L#, Fu J#, Sun C, Huang S, Xiao W, Gao Y, Liang Q, Wang X, Luo F, Lu W, Zhou Y*. Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. Theranostics 2020; 10:10908-24.
17. Yang L#, Han X#, Zhang C#, Sun C#, Huang S, Xiao W, Gao Y, Liang Q, Luo F, Lu W, Fu J*, Zhou Y*. Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus. Frontiers in Immunology 2020; 11:576903.
18. Yang L, Fu J, Zhou Y*. Research Progress in Atopic March. Frontiers in Immunology 2020; 11:1907.
19. Sun L#, Fu J#, Lin SH#, Sun JL#, Xia L, Lin CH, Liu L, Zhang C, Yang L, Xue P, Wang X, Huang S, Han X, Chen HL, Huang MS, Zhang X, Huang SK, Zhou Y*. Particulate matter of 2.5 mum or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1alpha in an asthma model. Journal of Allergy and Clinical Immunology 2020; 145:402-14.
20. Huang S#, Xue P#, Han X#, Zhang C, Yang L, Liu L, Wang X, Li H, Fu J*, Zhou Y*. Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis. Cell Death and Disease 2020; 11:408.
21. Han X#, Huang S#, Xue P#, Fu J#, Liu L, Zhang C, Yang L, Xia L, Sun L, Huang SK, Zhou Y*. LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE. Science Advances 2019; 5:eaax9230.
22. Zhang C, Fu J, Zhou Y*. A Review in Research Progress Concerning m6A Methylation and Immunoregulation. Frontiers in Immunology 2019; 10:922.
23. Yu J#, Luo Y#, Zhu Z#, Zhou Y#, Sun L, Gao J, Sun J, Wang G, Yao X*, Li W*. A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor. Journal of Allergy and Clinical Immunology 2019; 143:2108-19 e12.
24. Wang HC, Wong TH, Wang LT, Su HH, Yu HY, Wu AH, Lin YC, Chen HL, Suen JL, Hsu SH, Chen LC, Zhou Y, Huang SK*. Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase. Cellular and Molecular Immunology 2019; 16:783-90.
25. Wang E, Liu X, Tu W, Do DC, Yu H, Yang L, Zhou Y, Xu D, Huang SK, Yang P, Ran P, Gao PS*, Liu Z*. Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma. Allergy 2019; 74:1675-90.
26. Zhou Y#, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK*, Gao P*. Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p. Journal of Allergy and Clinical Immunology 2018; 141:350-64 e8.
27. Yang L, Fu J, Zhou Y*. Circular RNAs and Their Emerging Roles in Immune Regulation.Frontiers in Immunology 2018; 9:2977.
28. Xue P, Fu J, Zhou Y*. The Aryl Hydrocarbon Receptor and Tumor Immunity. Frontiers in Immunology 2018; 9:286.
29. Sun L, Fu J, Zhou Y*. Metabolism Controls the Balance of Th17/T-Regulatory Cells. Frontiers in Immunology 2017; 8:1632.
30. Qu J, Do DC, Zhou Y, Luczak E, Mitzner W, Anderson ME, Gao P. Oxidized CaMKII promotes asthma through the activation of mast cells. JCI Insight 2017; 2:e90139.
31. Kawasaki H, Chang HW, Tseng HC, Hsu SC, Yang SJ, Hung CH, Zhou Y, Huang SK*. A tryptophan metabolite, kynurenine, promotes mast cell activation through aryl hydrocarbon receptor. Allergy 2014; 69:445-52.
32. Zhou Y, Tung HY, Tsai YM, Hsu SC, Chang HW, Kawasaki H, Tseng HC, Plunkett B, Gao P, Hung CH, Vonakis BM, Huang SK*. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood 2013; 121:3195-204.
33. Zhou Y#, Kawasaki H#, Hsu SC, Lee RT, Yao X, Plunkett B, Fu J, Yang K, Lee YC, Huang SK*. Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nature Medicine 2010; 16:1128-33.
