Weijia Zhang, Ph.D.

Education

• 2009.09Ph.D. Degree, Department of Chemistry, Fudan University, China

• 2003.09B.S. Degree, Department of Chemical Engineering, Zhejiang University, China

Work experience

• 2016-Now, Professor, Institutes of Biomedical Sciences, Fudan University

Shanghai Cardiovascular Institute, Zhongshan Hospital Fudan Unviersity

• 2009-2016 Postdoctoral Researcher, Methodist Hospital Research Institute, Weill Cornell Medical College

Brigham Women Hospital, Harvard Medical School.

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032

Email:weijiazhang@fudan.edu.cn

Biography

Weijia Zhang received his doctorate in Chemistry from Fudan University. After graduation, he did his postdoctoral training at Methodist Hospital and Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School. In 2016, He returned to Fudan University with the financial support from "1000 Youth Talent" program, and joined Department of Chemistry and Institute of Biomedical Science (IBS) andShanghai Cardiovascular Institute Zhongshan Hospital at Fudan University. His research focuses primarily on i) Cardiovascular disease, ii) Aortopathy etiology and therapy. Dr. Zhang is now leading and collaborating with cross-functional research teams in the field of biomedical science and engineering, pharmaceutics, analytical chemistry, and microfabrication, to pioneer the mimicry of the in vivo biology and physiology for the purpose of drug development and cardiovascular disease modeling and analysis.

Research Areas & Interest

• Aortopathy

• Vasculopathy

• Microphysiological Systems Disease Modeling

Selected Publications

• Wenrui Ma, Jingjing Zhang, Shaowen Liu, Shiqiang Yan, Kehua Xu, Yu Shrike Zhang, Mieradilijiang Abudupataer, Yang Ming, Shichao Zhu, Bitao Xiang, Xiaonan Zhou, Shaman Luo, Hui Huang, Yuyi Tang, Shan Zhang, Zhuxin Xie, Nan Chen, Xiaoning Sun, Jun Li, Hao Lai, Chunsheng Wang*, Kai Zhu*, Weijia Zhang*, Patient-Derived Microphysiological Model Identifies the Therapeutic Potential of Metformin for Thoracic Aortic Aneurysm. eBiomedicine, 2022, 8, 104080.

• Hui Huang, Youpei Lin, Wenrui Ma, Jiannan Liu, Jing Han, Xiaoyi Hu, Meilin Tang, Shiqiang Yan, Chenping Zhang, Qiang Gao, Weijia Zhang*, A Pre-Screening Strategy to Assess Resected Tumor Margins by Imaging Mitochondrial Viscosity and Hypoxia. eLife, 2021, 10, 70471.

• Mieradilijiang, A., Zhu, S., Yan, S., Xu, K., Zhang, J., Luo, S., Ma, W., Alam, M. F., Tang, Y., Huang, H., Chen, N., Wang, L., Yan, G., Li, J., Lai, H., Wang, C.*, Zhu, K.*, and Zhang, W.* Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease. eLife, 2021, 10, 69310.

• Shiqiang Yan, Shuting Wang, Zhujing Hao, Meimei Liu, Chunyue Miao, Md Fazle Alam, Ruihan Bai, Linmei Li, Yong Luo, Tingjiao Liu, Bingcheng Lin, Weijia Zhang*, Yao Lu*. Rapid prototyping of PDMS microdevices via mu PLAT on nonplanar surfaces with flexible hollow-out mask. Biofabrication, 2021, 13, 035001.  

• Zhang, Q.;  Huang, Y.;  Jiang, B.;  Hu, Y.;  Xie, J.;  Gao, X.;  Jia, B.;  Shen, H.;  Zhang, W.*; Yang, P.* In situ Synthesis of Magnetic Mesoporous PhenolicResin for the Selective Enrichment of Glycopeptides. Analytical Chemistry, 2018, 90, 7357.

• Zhang Y.S.*, Zhang Y., and Zhang, W.* Cancer-on-a-chip systems at the frontier of nanomedicine. Drug discovery today 2017, 22, 1392-1399.

• Zhang, W.#, Zhang, Y.S.#, Bakht, S.M.#, Aleman, J., Shin, S.R., Yue, K., Sica, M., Ribas, J., Duchamp, M., Ju, J., Sadeghian, R.B, Kim.,D, Dokmeci, M.R., Atala, A., Khademhosseini, A.*,Elastomeric Free-Form Blood Vessels for Interconnecting Organs on Chip Systems, Lab on a Chip 2016, 16, 1579-1586.  (Cover, Lab on Chip Hot Articles)

• Zhang, W., Kai, K., Choi, D.S., Iwamoto, T., Nguyen, Y.H., Wong, H., Landis, M.D., Ueno, N.T.*, Chang, J.*, and Qin, L.* Microfluidics Separation Reveals the Stem-Cell–Like Deformability of Tumor-Initiating Cells, Proceedings of the National Academy of Sciences 2012, 109, 18707-18712. (Highlighted by Nature Methods 2013, 10, 14; Lab on Chip, 2013, 13, 599.)

• Zhang, W., Liu, Y., Cao, R., Li, Z., Zhang, Y., Tang, Y.,* Fan, K. Journal of the American Chemical Society 2008, 130, 15581-15588.