Education

1997-2000 Ph.D., Fudan University
1991-1994 Master, Henan Medical University

Work experience

2008-Present Professor, Institutes of Medical Sciences, Fudan University
2003-2008 Associate Professor, Bio-X Institutes, Shanghai Jiao Tong University
2000-2003 Postdoctoral Researcher, Shanghai Institutes for Biological Sciences, CAS
1994-1997 Lecturer, Henan Medical University

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 21 54237615

Email: qhxing@fudan.edu.cn

Biography

Dr. Qinghe Xing joined the Fudan University in 2008 as a professor in biochemistry and molecular biology in Institutes of Medical Sciences. Currently, Dr. Xing also serves as a professor in Children’s Hospital of Fudan University, a member of Genetic Counselling Experts Committee of Shanghai Municipal Health Commission and the Director of Laboratory of Shanghai Center for Women and Children's Health. Dr. Xing has been working on the neurodevelopmental disorders and Pharmacogenomics, with a strong interest in genetic mechanism and molecular diagnosis. His research works have been sponsored by the 973 Program, 863 program, the National Natural Science Foundation of China, the National Key Research and Development Program of China and the Shanghai Municipal Commission of Science and Technology Research Project. As either a (co-)corresponding author or a (co-)first author, he has published more than 90 peer-reviewed papers in high-profile journals including Hepatology, Am J Hum Genet, J Invest Dermatol, Br J Dermatol, J Neuroinflammation, J Eur Acad Dermatol Venereol and Neuropsychopharmacology. Outside research, he holds more than 10 China Patents, four of which have been applied in hospitals.

Research Areas

Identification and function of candidate genes for neurodevelopmental disorders.
Pharmacogenomics and precision medicine of severe adverse drug reaction.

Research interest

Pathogenesis and molecular diagnosis of neurodevelopmental disorders

Neurodevelopmental disorders are common and severe birth defects, ranking the first among disabling diseases in children. The immature brain has a strong compensatory ability, such that the earlier the intervention, the better the recovery of the child. The early intervention of neurodevelopmental disorders relies on early diagnosis, and there is still a lack of effective early diagnosis techniques in clinical practice. His research interests are broadly based on the obtained biological samples of children with cerebral palsy and global developmental delay, and the exome sequencing data of more than 2,000 cases, to explore the pathogenesis of neurodevelopmental disorders through technologies such as genetics, metabolomics and proteomics, to discover and verify new pathogenic genes, to search for molecular markers for early diagnosis or prenatal diagnosis of related birth defects, and to establish prenatal and newborn screening techniques.

Genetic mechanism and precise medicine of severe cutaneous adverse drug reactions

Severe cutaneous adverse drug reactions (SCARs) include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), etc. The clinical practice is greatly limited due to the high motality rate of SCARs, which can reach as high as 5-30%, and genetic factors play a key role in its occurrence. Identification of the risk alleles associated with SCARs may potentially prevent these reactions through pharmacogenetic screening. Now Dr. Xing already had a domestic leading genetic biobank for SCARs. He aims to establish a database of drug-risk allele pairs by resolving the genetic mechanism of important SCARs, and develop relevant precise medicine to reduce the incidence of SCARs.

Selected Publications

Qiu YL, Wang L, Huang M, Lian M, Wang F, Gong Y, Ma X, Hao CZ, Zhang J, Li ZD, Xing QH*, Cao M*, Wang JS*. Association of novel TMEM67 variants with mild phenotypes of high gamma-glutamyl transpeptidase cholestasis and congenital hepatic fibrosis. J Cell Physiol. 2022 Jun;237(6):2713-2723. IF=6.513
Jiang M, Yang F, Zhang L, Xu D, Jia Y, Cheng Y, Han S, Wang T, Chen Z, Su Y, Zhu Z, Chen S, Zhang J, Wang L, Yang L, Yang J, Luo X*, Xing Q*. Unique motif shared by HLA-B*59:01 and HLA-B*55:02 is associated with methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. J Eur Acad Dermatol Venereol. 2022 Jun;36(6):873-880. IF=9.228
Wang Y, Qiao Y, Cheng Y, Su Y, Song L, Xu Y, Li H, Zhang L, Song J, Zhang X, Wang J, Zhu D, Tang T, Shang Q, Gao C, Wang X, Zhu C*, Xing Q*. TEP1 is a risk gene for sporadic cerebral palsy. J Genet Genomics. 2021 Sep 17:S1673-8527(21)00282-4. IF=5.723
Qi Z, Xue Q, Wang H, Cao B, Su Y, Xing Q*, Yang JJ*. Serum CD203c+ Extracellular Vesicle Serves as a Novel Diagnostic and Prognostic Biomarker for Succinylated Gelatin Induced Perioperative Hypersensitive Reaction. Front Immunol. 2021 Sep 28;12:732209. IF=8.786
Liu J, Mayekar MK, Wu W, Yan M, Guan H, Wang J, Zaman A, Cui Y, Bivona TG, Choudhry H, Xing Q*, Cao W*. Long non-coding RNA ESCCAL-1 promotes esophageal squamous cell carcinoma by down regulating the negative regulator of APOBEC3G. Cancer Lett. 2020 Nov 28;493:217-227. IF=9.756
Xiong H, Jiang M, Shao F, Ye H, Zhang W, Chen Z, Zeng F, Chen SA, Yuan H, Yan L, Xing Q*, Luo X. Risk and Association of HLA Alleles with Methimazole-Induced Cutaneous Adverse Reactions in Chinese Han Population. J Invest Dermatol. 2021 Feb;141(2):437-440. IF=7.590
Qi Z, Li S, Su Y, Zhang J, Kang Y, Huang Y, Jin F, Xing Q*. Role of microRNA-145 in protection against myocardial ischemia/reperfusion injury in mice by regulating expression of GZMK with the treatment of sevoflurane. J Cell Physiol. 2019 Mar 14. doi: 10.1002/jcp.28323. IF=6.513
Wang J, Tian GG, Zheng Z, Li B, Xing Q, Wu J. Comprehensive Transcriptomic Analysis of Mouse Gonadal Development Involving Sexual Differentiation, Meiosis and Gametogenesis. Biol Proced Online. 2019;21:20. IF=7.717
Yan S, Lu Y, He L, Zhao X, Wu L, Zhu H, Jiang M, Su Y, Cao W*, Tian W*, Xing Q*. Dynamic editome of zebrafish under aminoglycosides treatment and its potential involvement in ototoxicity. Frontiers in Pharmacology. Front Pharmacol. 2017;8:854. IF=5.988
Zhou D, Wei Z, Kuang Z, Luo H, Ma J, Zeng X, Wang K, Liu B, Gong F, Wang J, Lei S, Wang D, Zeng J, Wang T, He Y, Yuan Y, Dai H, He L*, Xing Q*. A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation. J Cell Mol Med. 2017 Apr;21(4):802-815. IF=5.295
Qiu YL, Gong JY, Feng JY, Wang RX, Han J, Liu T, Lu Y, Li LT, Zhang MH, Sheps JA, Wang NL, Yan YY, Li JQ, Chen L, Borchers CH, Sipos B, Knisely AS, Ling V*, Xing QH*, Wang JS*. Defects in MYO5B are associated with a spectrum of previously undiagnosed low γ-glutamyltransferase cholestasis. Hepatology. 2017;65(5):1655-1669. IF=17.298
Li Y, Xu J, Chen M, Du B, Li Q, Xing Q*, Zhang Y*. A FBN1 mutation association with different phenotypes of Marfan syndrome in a Chinese family. Clin Chim Acta. 2016 Sep 1;460:102-6. IF=6.314
Bi D, Chen M, Zhang X, Wang H, Xia L, Shang Q, Li T, Zhu D, Blomgren K, He L, Wang X, Xing Q*, Zhu C*.The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy. J Neuroinflammation. 2014 Jun 6;11(1):100. IF=9.587
Zhang JY, Chen XD, Zhang Z, Wang HL, Guo L, Liu Y, Zhao XZ, Cao W*, Xing QH*, Shao FM. The adenosine deaminase acting on RNA 1 p150 isoform is involved in the pathogenesis of dyschromatosis symmetrica hereditaria. Br J Dermatol. 2013;169(3):637-44. IF=11.113
Guo L, Luo X, Zhao A, Huang H, Wei Z, Chen L, Qin S, Shao L, Xuan J, Feng G, Minghua C, Luan J, He L*, Xing Q*. A novel heterozygous nonsense mutation of keratin 5 in a Chinese family with Dowling-Degos disease. J Eur Acad Dermatol Venereol. 2012;26(7):908-10. IF=9.228