Wang Lei
Lei Wang, Ph.D.
PI, Associate Professor, 2011-2016, Fudan University
Assistant Professor, 2009-2011, Fudan University
Institutes of Biomedical Sciences, Fudan University, Shanghai 200032
Tel: +86-21-54237860
Email: wangleiwanglei@fudan.edu.cn
Lab homepage: https://reprod-genet.fudan.edu.cn
Dr. Lei Wang had his undergraduate training at Northwest University, China from 2000-2004. He then joined Dr. Lin He’s Lab in Shanghai Jiao Tong University to purse his Ph.D. degree from 2004-2009. After graduation in 2009, he was recruited as being an assistant professor in Fudan University. From 2017, he was a full professor in Fudan University. Dr. Wang got several prizes during recent years, including National Science Fund for Distinguished Young Scholars (2017), Science and technology innovation leader of National Ten-thousand Talents Program (2019), Tan Jiazhen Life Science Innovation Award (2019), VCANBIO Award for Biosciences and Medicine (2020), The first prize in Shanghai Natural Science Award (2020), Chief Scientist of the National Key R&D Program (2021), etc. He also served as being a member in several national academic committees.
Reproductive genetics, medical genetics, human genetics
Wang’s research focused on reproductive genetics. He is investigating on genetic basis and molecular mechanism of infertility caused by abnormal development of oocytes，fertilization and early embryos. He was the first to show oocyte maturation arrest is a new Mendelian disease (MIM:616780) and he identified the first and second disease-causing genes (TUBB8 and PATL2) for the disease. Besides, he also identified a few novel genes responsible for other kinds of female infertility, including fertilization failure, early embryonic arrest, et al. Till now, there are total 21 disease-causing genes responsible for abnormalities in the procedure of early human reproduction, among which Wang’s group identified 13 genes. His work incorporate disease pedigree, population cohort, cell model and mouse model to identify pathogenic genes responsible for diseases related to female infertility and its molecular mechanism. The findings were published in several journals, such as N Engl J Med, Science Transl Med,Am J Hum Genet, et al. These findings will provide molecular biomarkers for quality evaluation of oocytes and embryos, help patients having precision genetic diagnosis and pave the way for the future treatment.
2021 Chief Scientist of the National Key R&D Program
2020 The first prize in Shanghai Natural Science Award
2020 VCANBIO Award for Biosciences and Medicine
2019 Tan Jiazhen Life Science Innovation Award
2019 Science and technology innovation leader of National Ten-thousand Talents Program
2018 The “Dawn”Program of Shanghai Education Commission
2017 National Science Fund for Distinguished Young Scholars
2017 Youth Science and technology innovation leader of Science and Technology of China
2017 The first prize in National Women’s health Award
2016 Shanghai Science and Technology Rising Star
2016 Changjiang Scholars Program–Chang Jiang Scholars
2015 The second prize in National Women’s health Award
1.Zhang Z, Li B, Fu J, Li R, Diao F, Li C, Chen B, Du J, Zhou Z, Mu J, Yan Z, Wu L, Liu S, Wang W, Zhao L, Dong J, He L, Liang X, Kuang Y, Sun X, Sang Q*, Wang L*. Bi-allelic missense pathogenic variants in TRIP13 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2020 Jul 2;107(1):15-23.
2.Sang Q*, Zhang Z, Shi J, Sun X, Li B, Yan Z, Xue S, Ai A, Lyu Q, Li W, Zhang J, Wu L, Mao X, Chen B, Mu J, Li Q, Du J, Sun Q, Jin L, He L, Zhu S, Kuang Y*, Wang L*. A pannexin 1 channelopathy causes human oocyte death. Sci Transl Med. 2019 Mar 27;11(485): eaav8731.
3.Sang Q*, Li B, Kuang Y, Wang X, Zhang Z, Chen B, Wu L, Lyu Q, Fu Y, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Wang L*. Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet. 2018 Apr 5;102(4):649-657.
4.Chen B, Zhang Z, Sun X, Kuang Y, Mao X, Wang X, Yan Z, Li B, Xu Y, Yu M, Fu J, Mu J, Zhou Z, Li Q, Jin L, He L, Sang Q*, Wang L*. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2017 Oct 5;101(4):609-615.
5.Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ*, Wang L*. Mutations in TUBB8 and human oocyte meiotic arrest. N Engl J Med. 2016 Jan 21;374(3):223-32.
6.Xu Y, Shi Y, Fu J, Yu M, Feng R, Sang Q, Liang B, Chen B, Qu R, Li B, Yan Z, Mao X, Kuang Y, Jin L, He L, Sun X*, Wang L*. Mutations in PADI6 cause female infertility characterized by early embryonic arrest. Am J Hum Genet. 2016, Sep 1;99(3):744-52.
