Lu Zhigang
Zhigang Lu，Ph.D.
B.S. 1998, Peking University, China
Ph.D. 2003, School of life sciences, Peking University, Beijing, China
Postdoc training, 2003-2005, School of life sciences, Peking University, Beijing, China
Associate Professor, 2005-2012, Laboratory of Chemical Genomics, Shenzhen Graduate School of Peking University, Shenzhen, China
Assistant Professor, 2012-2017, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, USA
Principal Investigator, 2017-present, Institutes of Biomedical Sciences, Fudan University
Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 13816264968
Email: zhiganglu@fudan.educn
Prof. Zhigang Lu is the faculty of Institute of Biological Sciences, Fudan University. He obtained his B.S and Ph.D. from the School of life sciences of Peking University in China, and worked in UT Southwestern Medical Center in the area of hematopoiesis and leukemia from 2012-2017. His interest is focused on receptor-ligand interaction network on the cell surface, and their application in identifying novel targets for cancer immunotherapy and virus invasion. His work was published in the journals including Nature Medicine, Cell research, Science Advances, and Blood and so on.
Secretome protein-protein interactions
Novel drug targets for AML and ALL
Cancer immunotherapy
Pathogen-host interaction
The secretome, composed of cell-surface membrane proteins and extracellular secreted proteins that are synthesized through secretory machinery, represents one-third of protein-encoding genes in human genome and is central to cell communication with the environment. Aberrant Secretome protein–protein interactions (SPPIs) are associated with diseases including cancer, immune disorders, and illness caused by infectious pathogens. The lab is focused on 1) development of systemic tools to build up the secretome interaction network at specific settings and genomic level; 2) Identification of novel receptor-ligand pairs in tumor immunology and acute leukemias for cancer therapy; 3) Identifying the host receptome of infectious pathogens, and the key receptors/co-receptors that is required for pathogen-host interaction.
1.Jiang X, Wang J, Zheng X, Liu Z, Zhang X, Li Y, Wilhelm J, Sumer BD, Lea L, Lu Z#, Gao J#, Luo M#. Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy. Journal for ImmunoTherapy of Cancer, 2022 May, http://dx.doi.org /10.1136/jitc-2021-003960.
2.Gu Y, Cao J, Zhang X, Gao H, Wang Y, Wang J, He J, Jiang X, Zhang J, Shen G, Yang J, Zheng X, Xu J, Lan F, Qu D, Xu G, Zhao Y#, Gao D#, Xie Y#, Luo M#, Lu Z# . Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell Res, 2022 Jan;32(1):24-37.
3. Yang J, Shen G, Cao J, Zhang J, Gu Y, Zhang X, Jiang X, Luo M#, Lu Z#. Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2. Biochem Biophys Res Commun. 2022, 617, 42-47.
3.Chen, C., Hao, X., Lai, X., Liu, L., Zhu, J., Shao, H., Huang, D., Gu, H., Zhang, T., Yu, Z., Xie, L., Zhang, X., Yang, Y., Xu, J.#, Zhao, Y.#, Lu, Z.#, and Zheng, J. # (2021) Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia. Science Advances 2021 Mar 10;7(11):eabd6280.
4.Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek A. H, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You M. J, Homsi J, Unni N, Lewis C, Chen G. Q, Fu Y. X, Liao X. C, An Z, Zheng J, Zhang N, Zhang C. C. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature 2018, 562 (7728), 605-609.
5.Lu Z#, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC#. Fasting selectively blocks acute lymphoblastic leukemia development via leptin receptor upregulation. Nature Medicine. 2017. 23(1): 79-90.
6.Nakada, Y., Canseco D. C., Thet S., Abdisalaam S., Asaithamby A., Santos C. X., Shah A., Zhang H., Faber J. E., Kinter M. T., Szweda L. I., Xing C., Deberardinis R., Oz O., Lu Z., Zhang C. C., Kimura W. and Sadek H. A.. Hypoxia induces heart regeneration in adult mice. Nature. 2017. 541(7636): 222-227.
7.Luo M., Wang H., Wang Z., Cai H., Lu Z., Huang G., Chen X., Porembka M., Frankel A, Chen ZJ, Gao J. A STING-activating nanovaccine for cancer immunotherapy. Nat Nanotechnoloty. doi:10.1038/nnano.2017.52. 2017.
8.Kimura, W., Xiao F., Canseco D. C., Muralidhar S., Thet S., Zhang H. M., Abderrahman Y., Chen R., Garcia J. A., Shelton J. M., Richardson J. A., Ashour A. M., Asaithamby A., Liang H., Xing C., Lu Z., Zhang C. C. and Sadek H. A: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature, 2015, 523(7559): 226-230.
9.Kang X, Lu Z, Cui C, Deng M, Fan Y, Dong B, Han X, Xie F, Tyner JW, Coligan JE, Collins RH, Xiao X, You MJ, Zhang C.C: The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development. Nature Cell Biology, 2015; 17(5): 665–677.
10.Deng M*, Lu Z*, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao G.F, Jiang Y, Arase H, and Zhang C.C. A motif in LILRB2 critical for Angptl2 binding and activation. Blood. 2014. 924 - 935.
11.Zheng J.*, Lu Z.*, Kocabas F., Bottcher R. T., Costell M., Kang X., Liu X., Deberardinis R. J., Wang Q., Chen G., Sadek H., Zhang C. C. Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood. 2014. 123(7):992-1001.
12.Luo M., Ling T., Xie W., Sun H., Zhou Y., Zhu Q., Shen M., Zong L., Lyu G., Zhao Y., Ye T., Gu J., Tao W.#, Lu Z.#, Grummt I#. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells. 2013; 31:1278-1286.
13.Ling T., Xie W., Luo M., Shen M., Zhu Q., Zong L., Zhou T., Gu J., Lu Z. #, Zhang F. #, Tao W#. CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5. Biochem Biophys Res Commun. 2013;437:101-107.
14. Meng S, Luo M, Sun H, Yu X, Shen ML, Zhang QC, Zhou RD, Ju XF, Tao W, Liu D#, Deng HK#, Lu Z#. Identification and characterization of Bmi-1 responding element within the human p16 promoter. Journal of Biological Chemistry. 285, 33219-33229. 2010.
15. Luo M, Lu ZY, Sun H, Yuan KH, Zhang QC, Meng S, Wang FX, Guo HC, Ju XF, Liu YQ, Ye T, Lu Z#, Zhai Z. Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based spacific cleavage activity. Cell Research. 20:211-222. 2010.
16. Lu Z, Zhang CM, Zhai Z. Nucleoplasmin regulates chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. USA. 102(8): 2778-2783. 2005
