Education

09/2010-06/2015, Ph.D., Immunology, Fudan University, China.
09/2006-06/2010, B.S., Biology, Henan Normal University, China

Work experience

02/2018-present: Junior PI, Institutes of Biomedical Sciences, Fudan University
07/2015-01/2018: Postdoctoral Fellow, School of Basic Medical Sciences, Fudan University

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 54237362-601

Email: ronghualiu@fudan.edu.cn

Biography

Ronghua Liu, Ph. D., Junior PI, Master Supervisor, Fudan University. Research interest is adaptive immune regulation in tumor. Focusing on tumor-infiltrating B lymphocytes, Dr. Liu’s team systematically revealed the regulatory role of B cells in tumors and their clinical significane. The research results have been published on journals including Immunity (2022), Gastroenterology (2018), Hepatology (2022, 2017), Immunology (2022, 2019), and Clinical Cancer Research (2015). Research on tumor-associated B-cells is supported by five fundings from national and provincial projects. Dr. Liu was selected into Shanghai Science and Technology Star Program (2019), Outstanding Medical Talents Program of Shanghai Municipal Commission (2018), and won the 8th Young Scholar Award of Chinese Society for Immunology (2018), the Outstanding Paper Award of Shanghai Society for Social Immunology (2017), and Shanghai Natural Science Award, Second Prize (ranked second, 2020)

Research Areas

B-lymphocytes and Immune Regulation in Tumor.

Research interest

Immune system maintains body homeostasis, and its abnormalities involve disease initiation and progression of tumors, inflammation, and autoimmunity. B-lymphocytes secrete antibodies and mediate humoral immunity. We focus on B lymphocytes in tumor, trying to uncover the molecular basis of abnormal B-cell function involved in tumorigenesis and progression, and find potential targets for tumor immune elimination. At present, we have demonstrated the dual role of B cells in tumors, found their shift in function from effector to regulatory, and proposed a dietary intervention idea to control regulatory B cell (Breg) and prevent cancer immune escape. Ongoing projects plan to find the epigenetic and metabolic targets for limiting Breg and facilitating tumor immunotherapy.

Selected Publications

Wang Z#, Lu Z#, Lin S#, Xia J, Zhong Z, Xie Z, Xing Y, Qie J, Jiao M, Li Y, Wen H, Zhao P, Zhang D, Zhou P, Qian J, Luo F, Wang L, Yu H, Liu J, Gu J, Liu R*, Chu Y*. Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion. Immunity. 2022; 55(6):1067-1081.e8.
Lu Z#, Liu R#, Wang Y#, Jiao M#, Li Z, Wang Z, Huang C, Shi G, Ke A, Wang L, Fu Y, Xia J, Wen H, Zhou J, Wang X, Ye D, Fan J*, Chu Y*, Cai J*. Ten-eleven translocation-2 inactivation restrains IL-10-producing regμLatory B cells to enable antitumor immunity in hepatocellμLar carcinoma. Hepatology. 2022; doi:10.1002/hep.32442.
Xia J*, Xie Z*, Niu G, Lu Z, Wang Z, Xing Y, Ren J, Hu Z, Hong R, Cao Z, Han S, Chu Y, Liu R*, Ke C*. Single-cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer. Immunology. 2022; doi: 10.1111/imm.13568.
Zhong Z#, Nan K#, Weng M#, Yue Y, Zhou W, Wang Z, Chu Y, Liu R*, Miao C*. Pro- and Anti- Effects of Immunogloblin A- Producing B Cell in Tumors and Its Triggers. Front Immunol. 2021; 12:765044.
Gu J#, Mao W#, Ren W#, Xu F, Zhu Q, Lu C, Lin Z, Zhang Z, Chu Y, Liu R*, Ge D*. Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex. Cancer letters. 2019; 443:125-134.
Liu J#, Li Y, Lu Z, Gu J, Liang Y, Huang E, Wang Z, Zhang H, Wang L, Zhang D, Liu R*, Chu Y*. Deceleration of glycometabolism impedes IgG-producing B-cell-mediated tumor elimination by targeting SATB1. Immunology. 2019; 156(1):56-68.
Xu F#, Gu J#, Lu C#, Mao W, Wang L, Zhu Q, Liu Z, Chu Y, Liu R*, Ge D*. Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway. International journal of biological sciences. 2019; 15, 127-137.
Liu R#, Lu Z#, Gu J#, Liu J, Huang E, Liu X, Wang L, Yang J, Deng Y, Qian J, Luo F, Wang Z, Zhang H, Jiang X, Zhang D, Qian J, Liu G, Zhu H, Qian Y, Liu Z, Chu Y*. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2018; 154(3):637-651
Lu Z#, Liu J, Liu X, Huang E, Yang J, Qian J,3, Zhang D, Liu R*, Chu Y*. MiR-15a/16-1 Suppresses AHR-dependent IL-22 Secretion in CD4+ T cells and Contributes to Immune-mediated Organ Injury.Hepatology. 2017; 67(3):1027-1040
Liu R#, Gu J#, Jiang P, Zheng Y, Liu X, Jiang X, Huang E, Xiong S, Xu F, Liu G, Ge D*, Chu Y*. DNMT1-microRNA126 epigenetic circuit contributes to esophageal squamous cell carcinoma growth via ADAM9-EGFR-AKT signaling. Clin Cancer Res. 2015; 15; 21:854-863.