Shenglin Huang, Ph.D.

Education

B.S. 2003, Fujian Medical University

M.A. 2006, Shanghai Jiaotong University

Ph.D. 2009, Shanghai Jiaotong University

Work experience

Research Associate, 2009-2011, Shanghai Cancer Institute

Postdoc training, 2011-2013, Stanford University

Principal Investigator, since 2013, Fudan University

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032

Tel: +86 181 2129 9511

Email: slhuang@fudan.edu.cn

Lab homepage: http://www.x-mol.com/groups/huanglab

Biography

Prof. Huang obtained Ph.D. degree (2009) from Shanghai Jiaotong University School of Medicine in China. After graduation, Dr. Huang worked in State-key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute. From June, 2011 through July, 2013, Dr. Huang completed Postdoctoral training in Stanford University School of Medicine. In September, 2013, Dr. Huang was recruited to Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, and was appointed as Principal Investigator.

Research Areas

Molecular Oncology, RNA biology, Bioinformatics

Research interest

The Huang lab focuses on the discovery and functional elucidation of new targets for cancer diagnosis and treatment. His lab was first discovered the presence and application of circular RNA in exosomes. They revealed the exosomal / EV long RNAs (exLRs) and its application in cancer diagnosis. They found the abundant tumor-specific transcripts (TSTs) in cancer. They also established the exLR-seq, ASJA & EV-origin bioinformatics tools and exoRBase & RJunBase databases. They are interested in the identification, functional characterization, and clinical application of TSTs and exLRs in cancer. They are also interested in developing approaches and databases in the fields (eg. high-through sequencing, bioinformatics, extracellular vesicles, cancer vaccine) for cancer research and clinical application.

Selected Publications

1. Hongyan Lai, Yuchen Li, Hena Zhang, Jia Hu, Jiatao Liao, Ying Su, Qin Li, Bing Chen, Caiping Li, Zhen Wang, Yan Li, Jialei Wang, Zhiqiang Meng, Zhaohui Huang, Shenglin Huang. exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids. Nucleic Acids Research. 2022;50(D1):D118-D128.

2. Li Y, Chen B, Zhao J, Li Q, Chen S, Guo T, Li Y, Lai H, Chen Z, Meng Z, Guo W, He X, Huang S. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. Advanced Science. 2021, 2001701.

3. Qin Li, Hongyan Lai, Yuchen Li, Bing Chen, Siyuan Chen, Yan Li, Zhaohui Huang, Zhiqiang Meng, Peng Wang, Zhixiang Hu, Shenglin Huang. RJunBase: a database of RNA splice junctions in human normal and cancerous tissues. Nucleic Acids Research. 2021;49(D1):D201-D211.

4. Qiupeng Zheng, Jingjing Zhao, Hui Yu, Huajie Zong, Xigan He, Yiming Zhao, Yan Li, Yu Wang, Yichao Bao, Yuchen Li, Bing Chen, Weijie Guo, Yilin Wang, Zhiao Chen, Yingjun Zhao, Lu Wang, Xianghuo He, Shenglin Huang. Tumor-specific Transcripts are Frequently Expressed in Hepatocellular Carcinoma with Clinical Implication and Potential Function. Hepatology. 2020;71(1):259-274.

5. Yu S, Li Y, Liao Z, Wang Z, Wang Z, Li Y, Qian L, Zhao J, Zong H, Kang B, Zou WB, Chen K, He X, Meng Z, Chen Z, Huang S, Wang P. Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma. Gut. 2020;69(3):540-550.

6. Yuchen Li, Jingjing Zhao, Shulin Yu, Zhen Wang, Xigan He, Yonghui Su, Tianan Guo, Haoyue Sheng, Jie Chen, Qiupeng Zheng, Yan Li, Weijie Guo, Xiaohong Cai, Guohai Shi, Jiong Wu, Lu Wang, Peng Wang, Xianghuo He, Shenglin Huang. Extracellular vesicles long RNA sequencing reveals abundant mRNA, circRNA and lncRNA in human blood as biomarkers for cancer diagnosis. Clinical Chemistry. 2019;65(6):798-808.

7. Xiu B, Chi Y, Liu L, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH, Huang S, Wu J. LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. Mol Cancer. 2019;18(1):187.

8. Jingjing Zhao, Qin Li, Yuchen Li, Xianghuo He, Qiupeng Zheng, Shenglin Huang. ASJA: Assembling Splice Junctions Analysis. Computational and Structural Biotechnology Journal. 2019;17:1143-1150.

9. Guo W, Hu Z, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X, Huang S. A LIN28B Tumor-Specific Transcript in Cancer. Cell Reports. 2018; 22(8):2016-2025.

10. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research. 2018;46:D106–D112.

11. Qiupeng Zheng, Chunyang Bao, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen, Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He, Shenglin Huang. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications. 2016; 7:11215.

12. Yan Li, Qiupeng Zheng, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He, Shenglin Huang. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research. 2015;25(8):981-4.