Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032

Email: xhhe@fudan.edu.cn

Biography:

Xianghuo He has received his B.S. and M.S. degrees from East China Normal University in 1995 and 1998 respectively, and obtained his Ph.D. degree from Shanghai Medical College, Fudan University in 2003. From 2003 through 2006, Dr. He began his research on cancer cell signaling as a Postdoctoral research fellow at Department of Molecular & Cellular Oncology, UT M.D. Anderson Cancer Center. In 2006, Dr. He was recruited to State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, and was appointed as the Principal Investigator (PI) of Section of Functional Genomics in the national key laboratory from April, 2006 to December, 2013. Since January 2014, Dr. He is appointed as PI and professor at Institutes of Biomedical Sciences and Shanghai Cancer Center, Fudan University.

Dr. He is currently engaged in his scientific research on the genetic and epigenetic regulation of cancer development, progression and metastasis of human liver cancer. Dr. He has published over 120 articles in Nature Cell Biology, Gastroenterology, Hepatology, Cell Research, Advanced Science, Nature Communications, Nucleic Acids Research, Cancer Research, Clinical Cancer Research, etc. which are cited more than 11,200 times. H-index is 53 (Ref: ORCID:0000-0001-8872-668X; Web of Science ResearcherID:I-1497-2014).

Research Interests:

The research interests in Dr. He’s lab mainly focus on:

1, non-coding RNAs;

2, RNA alternative splicing;

3, Transcriptional reprogramming and epigenetic regulation.

Selected publications (* corresponding):

Li H, Song J, He Y, Liu Y, Liu Z, Sun W, Hu W, Lei Q, Hu X, Chen Z*, He X.* CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway. Advanced Science. 2022 Jul;9(21):e2105126.
Liang L, Huan L, Wang J, Wu Y, Huang S, He X.* LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation. Cell Discovery.2021 Dec 14;7(1):118.
Li Z, Lu X, Liu Y, Zhao J, Ma S, Yin H, Huang S, Zhao Y*, He X.* Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the HDAC6-TRIM28-ZNF354C Corepressor Complex. Hepatology.2021 May; 73(5):1764-1782.
Li Y, Chen B, Zhao J, Li Q, Chen S, Guo T, Li C, Lai H, Chen Z, Meng Z, Guo W*, He X.*, Huang S*. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. Advanced Science. 2021 May 1;8(13):2001701.
Ding J, Zhao J, Huan L, Liu Y, Qiao Y, Wang Z, Chen Z, Huang S, Zhao Y*, He X.*Inflammation-induced LINC00665 increases the malignancy through activating PKR/NF-κB pathway in hepatocellular carcinoma. Hepatology, 2020 Nov;72(5):1666-1681.
Hu Z, Dong L, Li S, Li Z, Qiao Y, Li Y, Ding J, Chen Z, Wu Y, Wang Z, Huang S, Gao Q*, Zhao Y*, He X.*Splicing Regulator p54^nrb/NONO Enhances Carcinogenesis via Oncogenic Isoform Switch of BIN1 in Hepatocellular Carcinoma. Hepatology. 2020 Aug;72(2):548-568.
Zheng Q, Zhao J, Yu H, Zong H, He X, Zhao Y, Li Y, Wang Y, Bao Y, Li Y, Chen B, Guo W, Wang Y, Chen Z, Zhao Y, Wang Y*, He X.*, Huang S*. Tumor-Specific Transcripts Are Frequently Expressed in Hepatocellular Carcinoma With Clinical Implication and Potential Function. Hepatology. 2020 Jan;71(1):259-274.
Li S, Hu Z, Zhao Y, Huang S, He X.*Transcriptome-Wide Analysis Reveals the Landscape of Aberrant Alternative Splicing Events in Liver Cancer. Hepatology. 2019 Jan;69(1):359-375.
Li Z, Zhang J, Liu X, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q^*, Zhao Y*, He X.*The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma. Nat Commun. 2018 Apr 20;9(1):1572.
Zhang J, Li Z, Liu L, Wang Q, Li S, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Huang S, Zhao Y*, He X.* Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway. Hepatology. 2018 Jan;67(1):171-187.
Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, Liang L, Gu J, He X,* Huang S*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 2016 Apr 6;7:11215.
Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M, Zhao Y*, He X.* MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology. 2015 Nov;149(6):1587-1598.e11.
Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X,* Huang S*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 2015 Aug;25(8):981-4.
Guo W, Qiu Z, Wang Z, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y*, He X.* MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology. 2015 Oct;62(4):1132-44.
Jia D, Dong R, Jing Y, Xu D, Wang Q, Chen L, Li Q, Huang Y, Zhang Y, Zhang Z, Liu L, Zheng S, Xia Q, Wang H*, Dong K*, He X.* Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex. Hepatology. 2014 Nov;60(5):1686-96.
Gao Q, Zhao YJ, Wang XY, Guo WJ, Gao S, Wei L, Shi JY, Shi GM, Wang ZC, Zhang YN, Shi YH, Ding J, Ding ZB, Ke AW, Dai Z, Wu FZ, Wang H, Qiu ZP, Chen ZA, Zhang ZF, Qiu SJ, Zhou J*, He XH*, Fan J*. Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients. Gastroenterology. 2014 May; 146(5): 1397-407.
Jia D, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X.* Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res. 2014 Feb;24(2):204-17.
Ding J, Huang S, Wang Y, Tian Q, Zha R, Shi H, Wang Q, Ge C, Chen T, Zhao Y, Liang L, Li J, He X.* Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology. 2013 Aug;58(2):654-66.
Ying Q, Liang L, Guo W, Zha R, Tian Q, Huang S, Yao J, Ding J, Bao M, Ge C, Yao M, Li J, He X.* Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology. 2011 Dec;54(6):2064-75.
Jia D, Wei L, Guo W, Zha R, Bao M, Chen Z, Zhao Y, Ge C, Zhao F, Chen T, Yao M, Li J, Wang H, Gu J, He X.* Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology. 2011 Oct; 54(4): 1227-36.
Zhao Y, Wang X, Wang T, Hu X, Hui X, Yan M, Gao Q, Chen T, Li J, Yao M, Wan D, Gu J*, Fan J*, He X.* Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology. 2011 Feb;53(2):493-503.
Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X.* MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology. 2010 Nov; 52(5): 1731-40.
Huang S, Wu S, Ding J, Lin J, Wei L, Gu J, He X.* MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions. Nucleic Acids Res. 2010 Nov;38(20):7211-8.
Ding J, Huang S, Wu S, Zhao Y, Liang L, Yan M, Ge C, Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X.* Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol. 2010 Apr;12(4):390-9.
Yao J, Liang L, Huang S, Ding J, Tan N, Zhao Y, Yan M, Ge C, Zhang Z, Chen T, Wan D, Yao M, Li J, Gu J, He X.* MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma. Hepatology. 2010 Mar;51(3):846-56.