Education

Ph.D. in Physics, University of Groningen, Groningen, the Netherlands (2006-2010)
M.Sc. in Chemistry, Tsinghua University, Beijing, China (2001-2005)
B. Sc. in Environmental Science, Tongji University, Shanghai, China (1997-2001)

Work experience

Principal Investigator The Fifth People’s Hospital of Shanghai & Institutes of Biomedical Sciences, Fudan University (July 2017-present)
Research Assistant Professor The University of Texas Southwestern Medical Center (May 2016-June 2017)
Postdoctoral Research Associate Purdue University (October 2010-April 2016)

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 21 54237007

Email: zhengguochen@fudan.edu.cn

Research Areas

Cryo-Electron Microscopy, Structural Biology, Microbiology

Research interest

We focus on the structure and function of pathogenic microbes (especially virus), using the advanced technique of cryo-electron microscopy (cryo-EM). Molecular structure of the viruses would provide fundamental understanding of the infection and transmission pathway. Furthermore, the complex structures of virus with antibody and virus with inhibitor would reveal the mechanisms of antibody neutralization and small molecule inhibition, and thereby pave the way toward vaccine development and drug discovery.

Selected Publications

Wang, Y.; Zhang, X.; Wang, Y.; Ma, Y.; Zhan, W.; Liu, J.; Zhang, M.; Liu, M.; Wang, Q.; Liu, Q.; Sun, T.; Zhu, T.; Wen, Y.; Sun, L*.; Zhao, J *.; Wu, F*.; Chen, Z.*; Huang, J*.; Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies. Cell Discovery 2022, (Accepted)(^#Co-first authors, ^*co-corresponding authors)
Zhan, W.; Tian, X.; Zhang, X.; Xing, S.; Song, W.; Liu, Q.; Hao, A.; Hu,Y., Zhang, M.; Ying, T.*;Chen, Z.*; Lan, F.*; Sun, L.*, Structural study of SARS-CoV-2 antibodies identifies a broad-spectrum antibody that neutralizes Omicron variant by disassembling the spike trimer. J Virol 2022, 96(16):e0048022.
Li, C.; Zhan, W.; Yang, Z.; Tu, C.; Hu, G.; Zhang, X.; Song, W.; Du, S.; Zhu, Y.; Huang, K.; Kong, Y.; Zhang, M.; Mao, Q.; Gu, X.; Zhang, Y.; Xie, Y.; Deng, Q.; Song, Y.; Chen, Z.; Lu, L.; Jiang, S.; Wu, Y.*; Sun, L.*; Ying, T.*, Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell 2022,185 (8), 1389-1401 e18.
Wang, Y.; Zhan, W.; Liu J.; Wang, Y.; Zhang, X.; Zhang, M.; Han, L.; Ma, Y.; Lu, L.; Wen, Y.; Chen, Z.; Zhao, J. *; Wu, F. *; Sun, L. * and Huang, J. *, A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Research 2022, 32: 862–865.
Liu, Z^#. Xu, W^#. Chen, Z^#. Fu, W^#. Zhan, W^#. Gao, Y^#. Zhou, J^#. Zhou, Y. Wu, J. Wang, Q. Zhang, X. Hao, A. Wu, W. Zhang, Q. Li, Y. Fan, K. Chen, R. Jiang, Q. Mayer, C. Schoofs, T. Xie, Y. Jiang, S. Wen, Y. Yuan, Z^*. Wang, K^*. Lu, L^*. Sun, L^*. Wang, Q^*. An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein & Cell 2022, 13(9): 655–675.
Wang, W^#. Wang, Z^#. Yang, X^#. Gao, Y^#. Zhang, X^#. Wang, W. Zhao, L. Zhang, J. Jing, Q. Xu, Q. Cao, L. Tian, Y. Sun, J. Sun, L. Jiang, L^*. Chen, Z^*. Wang, L^*. The molecular mechanism of cytoadherence to placenta or tumor cells through VAR2CSA from Plasmodium falciparum. Cell Discovery 2021, 7(1):94.
Chen, Z*. Sun, L*. Zhang, Z*. Fokine, A. Padilla-Sanchez, V. Hanein, D. Jiang, W. Rossmann, M. and Rao, V. Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-Å resolution and its relevance to the assembly of icosahedral viruses. Proc Natl Acad Sci USA 2017. 114(39):E8184–E8193.
Sirohi, D*. Chen, Z*. Sun, L. Klose, T. Rossmann, M. Kuhn, R. 3.8 Å Cryo-EM structure of Zika Virus. Science 2016.352(6284):467-470.
Liu, Y. Hill, MG. Klose, T. Chen, Z. Watters, K. Bochkov, YA. Jiang, W. Palmenberg, AC. Rossmann, MG. Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma.Proc Natl Acad Sci USA 2016. 113(32):8997-9002.
Sun, L*. Zhang, X*. Gao, S*. Rao, P. Padilla-Sanchez, V. Chen, Z. Sun, S. Xiang, Y. Subramaniam, S. Rao, V. Rossmann, M. Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nature Communications 2015. 6, 7548.