Xu Wei
Wei Xu, Ph.D.
2006 - 2011: Ph. D., Fudan University
Major: Biochemistry and Molecular Biology
2002- 2006: B.S., Zhejiang University, Bachelor of Science
Major: Science in biotechnology
2020-present：Senior Investigator，Fudan University
Major: Biochemistry and Molecular Biology
2016-2020：Associate Professor，Fudan University
Major: Biochemistry and Molecular Biology
2011-2016：Assistant Professor，Fudan University
Major: Biochemistry and Molecular Biology
Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86-21-31246782
Email: xuwei_0706@fudan.edu.cn
Lab homepage: http://metabolism.fudan.edu.cn
Wei Xu took her undergraduate training at College of Life Science, Zhejiang University from 2002 to 2006. Then she joined Dr. Kunliang Guan’s lab at Fudan University to pursue her Ph.D. degree in the field of acetylation regulation of metabolism and tumorigenic effect of metabolism disorder. After graduation in 2011, Dr. Xu joined the Institutes of Biomedical Sciences at Fudan University. She has made a series of contributions in the field of the tumor-promoting effects of deregulated oncometabolites signaling. She has published 15 papers, cited 4287 times as of January 2020, including 3 ESI highly cited papers. Her finding about 2-HG alters epigenetic marks has been included as new part in the text book “The Biology of Cancer” edited by R. Weinberg. She was also selected by the Changjiang Scholars Program (Young Scholars) of China.
Pathologic mechanisms of deregulated metabolites signaling
Wei Xu will focus on two aspects of metabolism:1) the sensing and transmitting of metabolites signaling, 2) pathologic mechanisms of deregulated metabolites signaling.
Metabolic reprogramming has been gradually recognized as an important feature of tumors in recent years. Tumor metabolic reprogramming involves changes in numerous metabolites utilization and signals. Xu and other researchers have found that glutamine, branched chain amino acids, 2HG and other metabolites disorders are closely related to tumorigenesis. However, the molecular mechanism of metabolites disorders leading to tumorigenesis is not clear, and further research is needed. Many works including the Xu’s have made a number of original breakthroughs, which are at the forefront of international research in tumor metabolic reprogramming. Xu will continue to do original research in this field.
Qian Zhou#, Wan-Wan Sun#, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-XingWu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu* & Shi-Min Zhao*, Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ, Nature Communications, (2022)
Hui-Lu Zhang#, Ping Chen#, He-Xin Yan#, Gong-Bo Fu#, Fei-Fei Luo, Jun Zhang, Shi-Min Zhao, Bo Zhai, Jiang-Hong Yu, Lin Chen, Hao-Shu Cui, Jian Chen, Shuai Huang, Jun Zeng, Wei Xu,* Hong-Yang Wang,* and Jie Liu*, Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation, Advanced Science, 2022
Song-Hua Hu#, Xia-Di He#, Ji Nie, Jun-Li Hou, Jiang Wu, Xiao-Yan Liu, Yun Wei, Hui-Ru Tang, Wen-Xing Sun, Shu-Xian Zhou, Yi-Yuan Yuan, Yan-Peng An, Guo-Quan Yan, Yan Lin, Peng-Cheng Lin, Jean J. Zhao, Ming-Liang Ye,* Jian-Yuan Zhao,* Wei Xu,* and Shi-Min Zhao*, Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake, Cell Reports, 2022
Yuan Fang#, Weiren Liu#, Zheng Tang#, Xiang Ji, Yufu Zhou, Shushu Song, Mengxin Tian, Chenyang Tao, Run Huang, Guiqi Zhu, Xifei Jiang, Jun Gao, Weifeng Qu, Han Wang, Peiyun Zhou, Xiaoling Wu, Lei Jin, Haixiang Sun, Zhenbin Ding, Yuanfei Peng, Shimin Zhao, Jian Zhou, Jia Fan, Wei Xu*, Yinghong Shi*, MCT4 inhibition potentiates hepatocellular carcinoma immunotherapy via enhancing T cell infiltration and immune attack, Hepatology, 2022
Jiao-Jiao Zhang#, Ting-Ting Fan#, Yun-Zi Mao#, Jun-Li Hou, Meng Wang, Min Zhang, Yan Lin, Lei Zhang, Guo-Quan Yan, Yan-Peng An, Jun Yao, Cheng Zhang, Peng-Cheng Lin, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu*, and Shi-Min Zhao*, Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation. Nature Metabolism. (2021)
Xin-Yu Mei#*, Da-Shi Qi#, Ting Zhang#, Yin Zhao#, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H. Finnell, Hexige Saiyin, Hong-Yan Wang*, Jian-Yuan Zhao*, Shi-Min Zhao*, and Wei Xu*. Inhibiting Methionyl-tRNA synthetase reduces neural tube defects and congenital heart defects onsets. EMBO Molecular Medicine. （2020）
Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yan-Hui Xu*, Wei Xu*, Shi-Min Zhao*, Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations. Cell Metabolism, 27（2018）
Ya-Kun Zhang#, Yuan-Yuan Qu#, Yan Lin#, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu*, Shi-Min Zhao*, and Wei Xu*, Enoyl-CoA Hydratase-1 Regulates mTOR Signaling and Apoptosis by Sensing Nutrients. Nature Communications, （2017）
Feng Li*, Xiadi He*, Dingwei Ye*, Yan Lin, Hongxiu Yu, Cuifang Yao, Lei Huang, Jianong Zhang, Fang Wang, Sha Xu, Xiaohui Wu, Lixia Liu, Chen Yang, Jiaqi Shi, Xiaoyang He, Jie Liu, Yuanyuan Qu, Fushen Guo, Jianyuan Zhao, Wei Xu#, and Shimin Zhao# NADP+-IDH mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. Molecular Cell. (2015)
Xu W* , Hui Yang*, Ying Liu*, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu, Qun-ying Lei, Kun-Liang Guan#, Shi-min Zhao#, and Yue Xiong#. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011)
Zhao, S-M., Xu, W. *, Jiang, W-Q. *, Yu, W., Lin, Y., Zhang, T-F., Yao, J., Zhou, L., Zeng, Y., Li, H., Li, Y., Shi, J., An, W-L., Hancock, S. M., He, F., Qin, L-X., Chin, J. C., Yang, P-Y., Chen, X., Lei, Q-Y., Xiong, Y. # and Guan, K-L. # Regulation of cellular metabolism by protein lysine acetylation. Science (2010)
Zhao, S-M., Li, Y.*, Xu, W. *, Jiang, W-Q. *, Zha, Z-Y., Yu, W., Li, Z-Q., Gong, L-L., Peng, Y-J., Ding, J-P., Lei, Q-Y., Guan, K-L.#, and Xiong, Y. # Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science (2009)
