Maoxiang (Max) Qian, Ph.D

Education

Shanghai Institutes for Biological Sciences and Graduate School，Chinese Academy of Sciences

PhD in Genetics，Graduated May 2011

Zhejiang University，College of Life Sciences

B.S. in Biotechnology，Graduated July 2004

Work experience

September 2018 – Present    Principal Investigator,Children’s Hospital / Institutes of Biomedical Sciences,Fudan University

June 2014 – August 2018    Postdoctoral Research Associate，Pharmaceutical Sciences, St. Jude Children’s Research Hospital

September 2011 – May 2014Senior Scientist II/Bioinformatics Group Leader，Genome Center (WuXi NextCODE), WUXI APPTEC SHANGHAI CO., LTD., Shanghai, China

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 13816456394

Email: mxqian@fudan.edu.cn

Research interest

My primary research interest is aimed to uncover the genetic basis of inter-patient variability in leukemia risk and anti-leukemic drug response, with a focus on Asian children with acute lymphoblastic leukemia (ALL). I am interested in combining bioinformatical/biostatistical analyses with wet lab experimentation in the study of molecular mechanisms of cancer and genetic diseases. My studies have discovered a distinct subtype of ALL with predominant genomic abnormalities of EP300/CREBBP (Genome Res 2017), identified non-coding oncogenic mutations in T-ALL (Blood 2017), revealed loss-of-function germline TP53 variants associated with ALL predisposition and adverse treatment outcomes, particularly the risk of second cancers (J Clin Oncol 2018), identified the fourth gene, IKZF1, that can predispose carriers to develop pediatric ALL (Cancer Cell 2018), and uncovered many novel susceptibility loci for childhood ALL (Blood 2019; JNCI 2019/2022; Nat Commun 2019). These findings not only shed new light on the molecular etiology of childhood ALL, but also provided potential opportunities for developing more targeted therapeutic agents in ALL.

Selected Publications

1.  Zhao X#, Qian M#, Goodings C, Zhang Y, Yang W, Wang P, Xu B, Tian C, Pui CH, Hunger SP, Raetz EA, Devidas M, Relling MV, Loh ML, Savic D, Li C, Yang JJ*. Molecular mechanisms of ARID5B-mediated genetic susceptibility to acute lymphoblastic leukemia. J Natl Cancer Inst. 2022 Sep 9;114(9):1287-1295. PMID: 35575404

2.  He H#, Li Z#, Lu J, Qiang W, Jiang S, Xu Y, Fu W, Zhai X, Zhou L, Qian M*, Du J*. Single-cell RNA-seq reveals clonal diversity and prognostic genes of relapsed multiple myeloma. Clin Transl Med. 2022 Mar;12(3):e757. PMID: 35297204.

3.  Jiang L#, Yin J#, Qian M#, Rong S, Zhang S, Chen K, Zhao C, Tan Y, Guo J, Chen H, Gao S, Liu T, Liu Y, Shen B, Yang J, Zhang Y, Meng FL, Hu J, Ma H, Chen YH. UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution. J Am Chem Soc. 2022 Jan 26;144(3):1323-1331. PMID: 35037455.

4.  An J#, Yin M#, Yin J#, Wu S, Selby CP, Yang Y, Sancar A, Xu GL, Qian M*, Hu J*. Genome-wide analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine at single-nucleotide resolution unveils reduced occurrence of oxidative damage at G-quadruplex sites. Nucleic Acids Res. 2021 Dec 2;49(21):12252-12267. PMID: 34788860.

5.  Li C, Liang W, He Y, Zhao X, Qian J, Li Z, Jiang C, Zheng Q, Fu X, Zhang W, Liu H, Sun X*, Qian M*, Zhang H*. Inherited GATA3 variant associated with positive minimal residual disease in childhood B-cell acute lymphoblastic leukemia via asparaginase resistance. Clin Transl Med. 2021 Aug;11(8):e507. PMID: 34459144.

6. Liu H#, Li Z#, Qiu F#, Li C, Lin X, He Y, Qian M*, Song Y*, Zhang H*. Association Between NR3C1 Mutations and Glucocorticoid Resistance in Children With Acute Lymphoblastic Leukemia. Front Pharmacol. 2021 Mar 29;12:634956.  PMID: 33854435.

7. Li Z#, Wang H#, Dong R, Man J, Sun L, Qian X, Zhu X, Cao P, Yu Y, Le J, Fu Y, Wang P, Jiang W, Shen C, Ma Y, Chen L, Xu Y, Shi J, Zhang H, Qian M*, Zhai X*. Single-Cell RNA-seq Reveals Characteristics of Malignant Cells and Immune Microenvironment in Subcutaneous Panniculitis-Like T-Cell Lymphoma. Front Oncol. 2021 Mar 18;11:611580. PMID: 33816243.

8. Zheng Q#, Jiang C#, Liu H, Hao W, Wang P, Huang H, Li Z, Qian J, Qian M*, Zhang H*. Down-Regulated FOXO1 in Refractory/Relapse Childhood B-Cell Acute Lymphoblastic Leukemia. Front Oncol. 2020 Nov 11;10:579673. PMID: 33262946.

9. Lee SHR#, Qian M#*, Yang W, Diedrich JD, Raetz E, Yang W, Dong Q, Devidas M, Pei D, Yeoh A, Cheng C, Pui CH, Evans WE, Mullighan CG, Hunger SP, Savic D, Relling MV, Loh ML, Yang JJ*. Genome-wide association study of susceptibility loci for TCF3-PBX1 acute lymphoblastic leukemia in children. J Natl Cancer Inst. 2021 Jul 1;113(7):933-937. PMID: 32882024.

10. Vijayakrishnan J#, Qian M#, Studd JB, Yang W, Kinnersley B, Law PJ, Broderick P, Raetz EA, Allan J, Pui CH, Vora A, Evans WE, Moorman A, Yeoh A, Yang W, Li C, Bartram CR, Mullighan CG, Zimmerman M, Hunger SP, Schrappe M, Relling MV, Stanulla M, Loh ML, Houlston RS*, Yang JJ*. Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk. Nat Commun. 2019 Nov 25;10(1):5348. PMID: 31767839.

11. Qian M, Zhao X, Devidas M, Yang W, Gocho Y, Smith C, Gastier-Foster JM, Li Y, Xu H, Zhang S, Jeha S, Zhai X, Sanda T, Winter SS, Dunsmore KP, Raetz EA, Carroll WL, Winick NJ, Rabin KR, Zweidler-Mckay PA, Wood B, Pui CH, Evans WE, Hunger SP, Mullighan CG, Relling MV, Loh ML, Yang JJ*. Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children. J Natl Cancer Inst. 2019 Dec 1;111(12):1350-1357. PMID: 30938820.

12. Qian M#, Xu H#, Perez-Andreu V, Roberts KG, Zhang H, Yang W, Zhang S, Zhao X, Smith C, Devidas M, Gastier-Foster JM, Raetz E, Larsen E, Burchard EG, Winick N, Bowman WP, Martin PL, Borowitz M, Wood B, Antillon-Klussmann F, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, and Yang JJ*. Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. Blood. 2019 Feb 14;133(7):724-729. PMID: 30510082.

13. Churchman ML#, Qian M#, Te Kronnie G#, Zhang R, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Peters JL, Devidas M, Larsen E, Moore IM, Gu Z, Qu C, Yoshihara H, Porter SN, Pruett-Miller SM, Wu G, Raetz E, Martin PL, Bowman WP, Winick N, Mardis E, Fulton R, Stanulla M, Evans WE, Relling MV, Pui CH, Hunger SP, Loh ML, Handgretinger R, Nichols KE, Yang JJ*, Mullighan CG*. Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. Cancer Cell. 2018 May 14;33(5):937-948.e8. doi: 10.1016/j.ccell.2018.03.021. Epub 2018 Apr 19. PMID: 29681510.

14. Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema NA, Zhang H, Moriyama T, Gastier-Foster JM, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ*. TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children. J Clin Oncol. 2018 Jan 4; JCO2017755215. PMID: 29300620.

15. Li L#, Qian M#, Chen IH, Finkelstein D, Onar-Thomas A, Johnson M, Calabrese C, Bahrami A, López-Terrada DH, Yang JJ, Tao WA, Zhu L*. Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice. Am J Pathol. 2017 Dec 14; PMID: 29248454.

16. Hu S#, Qian M#, Zhang H#, Guo Y#, Yang J, Zhao X, He H, Lu J, Pan J, Chang M, Du G, Lin TN, Kham SK, Quah TC, Ariffin H, Tan AM, Cheng Y, Li C, Yeoh AE, Pui CH, Skanderup AJ, Yang JJ*. Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations. Blood. 2017 Jun 15;129(24):3264-3268. PMID: 28408461.

17. Qian M#, Zhang H#, Kham SK, Liu S, Jiang C, Zhao X, Lu Y, Goodings C, Lin TN, Zhang R, Moriyama T, Yin Z, Li Z, Quah TC, Ariffin H, Tan AM, Shen S, Bhojwani D, Hu S, Chen S, Zheng H, Pui CH, Yeoh AE*, Yang JJ*. Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP. Genome Res. 2017 Feb;27(2):185-195. PMID: 27903646.

18. Qian M, Jin W, Zhu X, Jia X, Yang X, Du Y, Wang K*, Zhang J*. Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013 Apr 2;6:25. doi: 10.1186/1756-8722-6-25. PMID: 23547873.