Education

Doctor of Philosophy, Entomology, The Ohio State University, 2008
Bachelor of Science, Biochemistry & Molecular Biology, Peking University, 2001

Work experience

Scientist, Doctoral Advisor (2019 – present) Institutes of Biomedical Sciences & Children’s Hospital, Fudan University, Shanghai, China
Postdoctoral Associatem (2011 – 2017) Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA

Contact

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 Tel: +86 21-64932902

Email: b_han@fudan.edu.cn

Lab homepage:

Biography

Dr. Bing Han graduated from Peking University, the most elite institute of China with a Bsc degree in 2001, and obtained his PhD from Ohio State University in 2008. Subsequently, He completed the postdoctoral training in Baylor College of Medicine, revealing a ground-opening link between microbiota and host longevity. Since 2019, he has served as a primary investigator in Fudan University. The research is currently funded by Natural Science Foundation and National Key R&D Program of China.

Research Areas

Aging and associated diseases
Gut microbiome
Metabolism
Model of Caenorhabditis elegans

Research interest

The research topics span across basic biomedical disciplines and clinical applications, with the main goal of translating new insights on microbiota functions to cure most challenging diseases. On one hand, using the nematode-bacteria model system, the research team aims to deciphering causal relationships between microbiome properties and host pathologies as well as their underlying mechanisms. On the other hand, the goal is to identify any microbial variants or metabolites potent in antagonizing diseases. The research will shed great light on microbiota engineering and bacteria-derived medicine development, holding great potential in treating various diseases including tumors, neural degeneration, diabetes, obesity as well as genetic development disorders.

Selected Publications

Yuan, X., Wang, R., Han, B., Sun, C., Chen, R-M., Wei, H., Chen, L., Du, H., Li, G., Yang, Y., Chen, X., Cui, L., Xu, Z., Fu, J., Wu, J., Gu, W., Chen, Z., Fang, X., Yang, H., Su, Z., Wu, J., Li, Q., Zhang, M., Zhou, Y., Zhang, L., Ji, G., Luo, F. (2022) Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes. Nature Communications, accepted.
Hartsough, L. A., Park, M., Kotlajich, M. V., Lazar, J. T., Han, B., Lin, C. J., Musteata, E., Gambill, L., Wang, M. C., Tabor, J. J. (2020) Optogenetic control of gut bacterial metabolism. Elife, 9: e56849.
Han, B., Lin, C. J., Hu, G., Wang, M. C. (2019) ‘Inside Out’: a dialogue between mitochondria and bacteria. The FEBS Journal, 286(4): 630-641.
Han, B., Sivaramakrishnan, P., Lin, C. J., Neve, I. A. A., He, J., Tay, L. R., Sowa, J. N., Sizovs, A., Du, G., Wang, J., Herman, C., Wang, M. C. (2017) Microbial genetic composition tunes host longevity. Cell, 169(7): 1249-1262.
Han, B., Denlinger, D. L. (2009) Length variation in a specific region of the period gene correlates with differences in pupal diapause incidence in the flesh fly, Sarcophaga bullata. Journal of Insect Physiology, 55(5): 415-418.
Han, B., Denlinger, D. L. (2009) Mendelian inheritance of pupal diapause in the flesh fly, Sarcophaga bullata. Journal of Heredity, 100(2): 251-255.
Goto, S. G., Han, B., Denlinger D. L. (2006) A nondiapausing variant of the flesh fly, Sarcophaga bullata, that shows arrhythmic adult eclosion and elevated expression of two circadian clock genes, period and timeless. Journal of Insect Physiology, 52(11-12): 1213–1218.