课题组致力于翻译调控的分子机制的研究。主要运用结构生物学手段（冷冻电镜和X射线晶体衍射）结合生化细胞实验，阐释细胞内(细胞质和线粒体)核糖体调控的分子机制：包括核糖体的组装与降解，核糖体修饰，以及核糖体质量控制等。我们同时也对其他的核酸蛋白复合物感兴趣。已发表SCI论文35篇，其中：通讯作者4篇（Nature communication，EMBO Journal, PLOS Biology， Nucleic Acids Research），第一作者（或共同第一作者）12篇（其中：Cell 1篇,Nature 2篇, Science 1篇,Molecular Cell 2篇）等。

代表论文

1. Cheng J* , Berninghausen O, Beckmann R*. A distinct assembly pathway of the human 39S late pre-mitoribosome. Nature communication,in press. *共同通讯

2. Su, T, Kudva, R, Becker, T, Buschauer, R, Komar, T, Berninghausen, O, Heijne, G, Cheng, J*, Beckmann, R*, Structural basis of L-tryptophan-dependent inhibition of Release Factor 2 by the TnaC arrest peptide, Nucleic Acids Research, in press. *共同通讯

3. Weng T, Steinchen W, Beatrix B, Berninghausen O, Becker T, Bange G, Cheng J* , Beckmann R*. Architecture of the active post-translational Sec translocon. EMBO J. 2021 Feb 1;40(3):e105643.*共同通讯

4. Wells JN, Buschauer R, Mackens-Kiani T, Best K, Kratzat H, Berninghausen O, Becker T, Gilbert W, Cheng J*, Beckmann R*. Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. PLoS Biol. 2020 Jul 20;18(7):e3000780. *共同通讯

5. Lau B#, Cheng J#, Flemming D, La Venuta G, Berninghausen O, Beckmann R*, Hurt E*. Structure of the maturing 90S pre-ribosome in association with the RNA exosome. Mol Cell. 2021 Jan 21;81(2):293-303.e4. #共同第一

6. Cheng J#, Lau B#, La Venuta G, Ameismeier M, Berninghausen O, Hurt E*, Beckmann R*. 90S pre-ribosome transformation into the primordial 40S subunit. Science. 2020 Sep 18;369(6510):1470-1476.

7. Cheng J#, Baßler J#, Fischer P#, Lau B, Kellner N, Kunze R, Griesel S, Kallas M, Berninghausen O, Strauss D, Beckmann R*, Hurt E*, Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration. Mol Cell. 2019 Sep 19;75(6):1256-1269.e7.

8. Ameismeier M#, Cheng J#, Berninghausen O, Beckmann R. Visualizing late states of human 40S ribosomal subunit maturation. Nature. 2018 June 14; 558 :249-253.#共同第一

9. Cheng J, Kellner N, Berninghausen O, Hurt E, Beckmann R. 3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage. Nat Struct Mol Biol. 2017 Nov;24(11):954-964.

10. Hu L#, Lu J#, Cheng J#, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Structural insight into substrate preference for TET-mediated oxidation. Nature. 2015 Nov 5;527(7576):118-22.#共同第一

11. Hu L#, Li Z#, Cheng J#, Rao Q, Gong W, Liu M, Shi YG, Zhu J, Wang P, Xu Y. Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation. Cell. 2013 Dec 19;155(7):1545-55. #共同第一

12.Cheng J#, Yang H#, Fang J, Ma L, Gong R, Wang P, Li Z, Xu Y. Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun. 2015 May 11;6:7023.