全聘课题组长
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  • 徐国良

    博士,教授,博士生导师,中国科学院院士
    地址:东安路131号,科研二号楼A5-001,上海200032
    电话:021-54127726(办公室);021-54237269(实验室)
    邮箱:xugl@fudan.edu.cn

工作经历
教授,执行院长(兼),复旦大学生物医学研究院(2017.03-今)
研究员,中国科学院上海生化与细胞研究所(2001.08-今)
Associate Research Scientist,哥伦比亚大学医学系(2000.04-2001.07)
博士后,哥伦比亚大学遗传发育系(1995.10-2000.03)
实验室主任,新加坡国立大学生命科学中心(1994.08-1995.09)
博士后,德国马普分子遗传学研究所(1993.03-1994.07)
教育经历
博士,德国马普分子遗传学研究所(1989-1993)
硕士,中国科学院北京遗传所(1985-1988)
学士,浙江大学生物系(1981-1985)
所获人才项目
国家杰出青年科学基金,国家自然科学基金,2001
所获奖项
何梁何利科学与技术进步奖何梁何利基金会,2017
上海市自然科学一等奖上海市人民政府,2016
陈嘉庚生命科学奖陈嘉庚科学奖基金会,2014
TWAS生物学奖第三世界科学院,2013
研究方向
以染色质共价修饰为主要研究对象的表观遗传学研究 ,因其作用广泛、影响深远,已经引起了越来越多的重视并成为目前生命科学研究中发展迅速而崭新的研究领域。本课题组采用生物化学、细胞生物学和遗传学(包括基因组学)相互依托的实验手段致力于探索DNA甲基化谱式在胚胎发育早期建立的分子生物学机制以及DNA表观修饰对胚胎干细胞与成体干细胞自我更新和分化的调控方式,并探究这一平衡的改变如何导致肿瘤和疾病发生,从而增加人们对生长发育与疾病发生发展的分子机理的理解。

近年来,课题组主要从事的研究内容包括

1)在哺乳动物细胞中寻找新的碱基修饰形式及生物学功能;

2)探索对造血稳态维持和血液恶性肿瘤疾病发生发展至关重要的表观遗传调控机制;

3)探索心脏祖细胞命运决定原理,寻找开发应对心脏等器官发育缺陷与病变的新策略。

相关研究拟为造血系统的体外扩增建立新的技术体系,为血液疾病的临床诊断治疗提供新的思路,同时为维护人类健康尤其是再生医学的技术开发提供理论依据。

代表论文

1.Bin Chen, Ya-Rui Du, Hong Zhu, Mei-Ling Sun, Chao Wang, Yi Cheng, Haiyan Pang, Guolian Ding, Juan Gao, Yajing Tan, Xiaomei Tong, Pingping Lv, Feng Zhou, Qitao Zhan, Zhi-Mei Xu, Li Wang, Donghao Luo, Yinghui Ye, Li Jin, Songying Zhang, Yimin Zhu, Xiaona Lin, Yanting Wu, Luyang Jin, Yin Zhou, Caochong Yan, Jianzhong Sheng, Peter R. Flatt,Guo-Liang Xu* & Hefeng Huang*. (2022) Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency. Nature. doi: 10.1038/s41586-022-04756-4

2.Qin Xu, Chao Wang, Jia-Xin Zhou, Zhi-Mei Xu, Juan Gao, Peng-Fei Sui, Colum P Walsh, Hong-Bin Ji* & Guo-Liang Xu*. Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development. PNAS. 119(6):e2107599119

3.Guo-Liang Xu*, Matthias Bochtler*. (2020) Reversal of nucleobase methylation by dioxygenases. Nat Chem Biol. 16, 1160-1169.

4.Jian-Huang Xue, Guo-Dong Chen, Fuhua Hao, Hui Chen, Zhaoyuan Fang, Fang-Fang Chen, Bo Pang, Qing-Lin Yang, Xinben Wei, Qiang-Qiang Fan, Changpeng Xin, Jiaohong Zhao, Xuan Deng, Bang-An Wang, Xiao-Jie Zhang, Yueying Chu, Hui Tang, Huiyong Yin, Weimin Ma, Luonan Chen, Jianping Ding, Elmar Weinhold, Rahul M. Kohli, Wen Liu, Zheng-Jiang Zhu, Kaiyao Huang, Huiru Tang* & Guo-Liang Xu*. (2019) A vitamin-C-derived DNA modification catalysed by an algal TET homologue. Nature. 569, 581-585.

5.Hai-Qiang Dai, Bang-An Wang, Lu Yang, Jia-Jia Chen, Guo-Chun Zhu, Mei-Ling Sun, Hao Ge, Rui Wang, Deborah L. Chapman, Fuchou Tang, Xin Sun*, Guo-Liang Xu*. (2016). TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 538, 528-532.

6.Fan Guo, Xianlong Li, Dan Liang, Tong Li, Ping Zhu, Hongshan Guo, Xinglong Wu, Lu Wen, Tian-Peng Gu, Colum P.Walsh, Jinsong Li*, Fuchou Tang*, Guo-Liang Xu*.(2014). Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote. Cell Stem Cell. 15, 477-458.

7.Xiao Hu, Lei Zhang, Shi-Qing Mao, Zheng Li, Jiekai Chen, Run-Rui Zhang, Hai-Ping Wu, Juan Gao, Fan Guo, Wei Liu, Gui-Fang Xu, Hai-Qiang Dai, Yujiang Geno Shi, Xianlong Li, Boqiang Hu, Fuchou Tang, Duanqing Pei, Guo-Liang Xu*. (2014). Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming. Cell Stem Cell. 14,512-522.

8.Run-Rui Zhang, Qing-Yan Cui, Kiyohito Murai, Yen Ching Lim, Zachary D. Smith, Shengnan Jin, Peng Ye, Luis Rosa, Yew Kok Lee, Hai-Ping Wu, Wei Liu, Zhi-Mei Xu, Lu Yang, Yu-Qiang Ding, Fuchou Tang, Alexander Meissner, Chunming Ding*, Yanhong Shi*, Guo-Liang Xu*. (2013) Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition. Cell Stem Cell. 13, 237-245.

9.Jiekai Chen, Lin Guo, Lei Zhang, Haoyu Wu, Jiaqi Yang, He Liu, Xiaoshan Wang, Xiao Hu, Tianpeng Gu, Zhiwei Zhou, Jing Liu, Jiadong Liu, Hongling Wu, Shi-Qing Mao, Kunlun Mo, Yingying Li, Keyu Lai, Jing Qi, Hongjie Yao, Guangjin Pan, Guo-Liang Xu*, Duanqing Pei*. (2013). Vitamin C modulates Tet1 function during somatic cell reprogramming. Nature Genetics. 45,1504-1509.

10.Hui Yang, Linyu Shi, Bang-An Wang, Dan Liang, Cuiqing Zhong, Wei Liu, Yongzhan Nie, Jie Liu, Jing Zhao, Xiang Gao, Dangsheng Li, Guo-Liang Xu*, Jinsong Li*. (2012) Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells. Cell. 149,605-617.

11.Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li, Yan Sun, Xiuxue Li, Qing Dai, Chun-Xiao Song, Kangling Zhang, Chuan He, Guo-Liang Xu*. (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science, 333, 1303-07.

12.Tian-Peng Gu, Fan Guo, Hui Yang, Hai-Ping Wu, Gui-Fang Xu, Wei Liu, Zhi-Guo Xie, Linyu Shi, Xinyi He, Seung-gi Jin, Khursheed Iqbal, Yujiang Geno Shi, Zixin Deng, Piroska E. Szabó, Gerd P. Pfeifer, Jinsong Li* and Guo-Liang Xu*. (2011) The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature, 477,606-610.


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